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Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry

Drug metabolism and disposition, 2014-05, Vol.42 (5), p.885-889

2014

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Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry

Drug metabolism and disposition, 2012-07, Vol.40 (7), p.1389-1396

2012

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Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver

Drug metabolism and disposition, 2012-05, Vol.40 (5), p.902-906

2012

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Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist

Xenobiotica, 2012-10, Vol.42 (10), p.957-967

2012

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Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.276-282

2012

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Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes

Biological and Pharmaceutical Bulletin, 2012/03/01, Vol.35(3), pp.413-421

2012

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Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities

Xenobiotica, 2012-09, Vol.42 (9), p.823-829

2012

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In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist

Xenobiotica, 2012-12, Vol.42 (12), p.1187-1196

2012

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Absorption, Metabolism and Excretion of [ 14 C]Mirabegron (YM178), a Potent and Selective β 3 -Adrenoceptor Agonist, after Oral Administration to Healthy Male Volunteers

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.815-824

2012

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Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers

Drug metabolism and disposition, 2012-04, Vol.40 (4), p.815

2012

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The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function

Journal of clinical pharmacology, 2017-04, Vol.57 (4), p.524-535

2017

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Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β3‑Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems

Molecular pharmaceutics, 2013-05, Vol.10 (5), p.1783-1794

2013

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Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans

Xenobiotica, 2013-06, Vol.43 (6), p.534-547

2013

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Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β 3 -Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems

Molecular pharmaceutics, 2013-05, Vol.10 (5), p.1783-1794

2013

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Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β 3 -adrenoceptor agonist

Xenobiotica, 2012-10, Vol.42 (10), p.957-967

2012

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Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia

Hypertension in pregnancy, 2014-02, Vol.33 (1), p.93-101

2014

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Pharmacokinetics, distribution and excretion of YM155 monobromide, a novel small-molecule survivin suppressant, in male and pregnant or lactating female rats

Biopharmaceutics & drug disposition, 2012-04, Vol.33 (3), p.160-169

2012

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Solid-Phase Extraction Followed by Purification with Tri-n-Butylphosphate as a Simple and Useful Rat Plasma Clean-up Method for HPLC-UV Determination of Zonampanel Monohydrate (YM872), a Highly Water-Soluble α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist

Journal of liquid chromatography & related technologies, 2008-02, Vol.31 (7), p.1072-1080

2008

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Carboxylesterase activity in long-term cultures of spheroid composed of rat liver parenchymal and non-parenchymal cells

Japanese Journal of Pharmacology, 1993, Vol.61 (suppl.2), p.345-345

1993

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Suppresion of humoral and cell-mediated immune response by acetaminohen in mice

Japanese journal of pharmacology, 1991, Vol.55, p.80

1991

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O-047 - Suppresion of humoral and cell-mediated immune response by acetaminohen in mice

Japanese journal of pharmacology, 1991, Vol.55, p.80-80

1991

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P-630 - Carboxylesterase activity in long-term cultures of spheroid composed of rat liver parenchymal and non-parenchymal cells

Japanese journal of pharmacology, 1993, Vol.61, p.345-345

1993

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An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

Japanese Journal of Pharmacology, 1993, Vol.61 (suppl.2), p.345-345

1993

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An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

Japanese journal of pharmacology, 1993, Vol.61, p.345

1993

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P-629 - An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

Japanese journal of pharmacology, 1993, Vol.61, p.345-345

1993

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Optimized methods for targeted peptide-based quantification of human uridine 5'-diphosphate-glucuronosyltransferases in biological specimens using liquid chromatography-tandem mass spectrometry

Simultaneous absolute protein quantification of carboxylesterases 1 and 2 in human liver tissue fractions using liquid chromatography-tandem mass spectrometry

Conclusive identification of the oxybutynin-hydrolyzing enzyme in human liver

Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β3-adrenoceptor agonist

Identification of UDP-glucuronosyltransferases responsible for the glucuronidation of darexaban, an oral factor Xa inhibitor, in human liver and intestine

Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes

Protein quantification of UDP-glucuronosyltransferases 1A1 and 2B7 in human liver microsomes by LC-MS/MS and correlation with glucuronidation activities

In vitro inhibition and induction of human cytochrome P450 enzymes by mirabegron, a potent and selective β3-adrenoceptor agonist

Absorption, Metabolism and Excretion of [ 14 C]Mirabegron (YM178), a Potent and Selective β 3 -Adrenoceptor Agonist, after Oral Administration to Healthy Male Volunteers

Absorption, metabolism and excretion of [(14)C]mirabegron (YM178), a potent and selective β(3)-adrenoceptor agonist, after oral administration to healthy male volunteers

The Pharmacokinetics of Beraprost Sodium Following Single Oral Administration to Subjects With Impaired Kidney Function

Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β3‑Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems

Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans

Intestinal Absorption Mechanism of Mirabegron, a Potent and Selective β 3 -Adrenoceptor Agonist: Involvement of Human Efflux and/or Influx Transport Systems

Identification of human cytochrome P450 isoforms and esterases involved in the metabolism of mirabegron, a potent and selective β 3 -adrenoceptor agonist

Placental transfer of intravenous nicardipine and disposition into breast milk during the control of hypertension in women with pre-eclampsia

Pharmacokinetics, distribution and excretion of YM155 monobromide, a novel small-molecule survivin suppressant, in male and pregnant or lactating female rats

Solid-Phase Extraction Followed by Purification with Tri-n-Butylphosphate as a Simple and Useful Rat Plasma Clean-up Method for HPLC-UV Determination of Zonampanel Monohydrate (YM872), a Highly Water-Soluble α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Antagonist

Carboxylesterase activity in long-term cultures of spheroid composed of rat liver parenchymal and non-parenchymal cells

Suppresion of humoral and cell-mediated immune response by acetaminohen in mice

O-047 - Suppresion of humoral and cell-mediated immune response by acetaminohen in mice

P-630 - Carboxylesterase activity in long-term cultures of spheroid composed of rat liver parenchymal and non-parenchymal cells

An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

P-629 - An experimental acute liver injury model using multicellular spheroids composed of rat liver cells

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