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Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2‑Carbamoylphenyl Piperidine Moiety

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10352-10379

2020

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GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

PloS one, 2019-09, Vol.14 (9), p.e0222653-e0222653

2019

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Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

Bioorganic & medicinal chemistry, 2011-08, Vol.19 (15), p.4482-4498

2011

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A Silyl Substituent Can Dictate a Concerted Electrocyclic Pathway: Inward Torquoselectivity in the Ring Opening of 3-Silyl-1-cyclobutene

Angewandte Chemie (International ed.), 2001-01, Vol.40 (1), p.189-190

2001

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Stereoselective Synthesis of Isomeric Functionalized 1,3-Dienes from Cyclobutenones

Journal of the American Chemical Society, 2001-07, Vol.123 (26), p.6441-6442

2001

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SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

The Journal of pharmacology and experimental therapeutics, 2019-08, Vol.370 (2), p.172

2019

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Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Bioorganic & medicinal chemistry, 2020-04, Vol.28 (7), p.115376-115376, Article 115376

2020

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Torque control by metal-orbital interactions

Pure and applied chemistry, 2006-01, Vol.78 (2), p.415-423

2006

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Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554

Bioorganic & medicinal chemistry letters, 2017-08, Vol.27 (15), p.3565-3571

2017

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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

Bioorganic & medicinal chemistry, 2018-05, Vol.26 (9), p.2452-2465

2018

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1161-P: SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control More Than That by Fasiglifam in Rat Models of Diabetes and Obesity

Diabetes (New York, N.Y.), 2019-06, Vol.68 (Supplement_1)

2019

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Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes

Bioorganic & medicinal chemistry, 2017-11, Vol.25 (21), p.5995-6006

2017

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Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Journal of medicinal chemistry, 2011-02, Vol.54 (3), p.831-850

2011

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Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

Bioorganic & medicinal chemistry, 2011-08, Vol.19 (16), p.4953-4970

2011

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A Silyl Substituent Dictates the Pathway of a Concerted Electrocyclic Ring-opening of Cyclobutene

Journal of Synthetic Organic Chemistry, Japan, 2002/11/01, Vol.60(11), pp.1049-1054

2002

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Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Bioorganic & medicinal chemistry, 2011-01, Vol.19 (1), p.172-185

2011

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Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

Bioorganic & medicinal chemistry, 2011-09, Vol.19 (18), p.5742-5742

2011

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Ein Silylsubstituent steuert eine elektrocyclische Reaktion: Stereoselektivität bei der Ringöffnung von 3-Silyl-1-cyclobuten

Angewandte Chemie, 2001-01, Vol.113 (1), p.182-184

2001

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Effect of Hyperglycemia and Hypoglycemia on the Myo-inositol Content in Various Nerve Tissues of Rats

Journal of the Japan Diabetes Society, 1987/06/30, Vol.30(6), pp.503-510

Miyamoto, Yasufumi

1987

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Successful resection of pheochromocytoma in a hemodialysis patient

American journal of nephrology, 1992-01, Vol.12 (1-2), p.111

1992

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Ein Silylsubstituent steuert eine elektrocyclische Reaktion: Stereoselektivität bei der Ringöffnung von 3‐Silyl‐1‐cyclobuten

Angewandte Chemie, 2001-01, Vol.113 (1), p.182-184

2001

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Airway Basophil and Mast Cell Density in Patients with Bronchial Asthma: Relationship to Bronchial Hyperresponsiveness

The Journal of asthma, 1996, Vol.33 (2), p.89-95

1996

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The Myo-Inositol Content of Various Nerve Tissues from Streptozotocin-Diabetic Rats

Journal of the Japan Diabetes Society, 1986/10/30, Vol.29(10), pp.965-968

1986

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A Silyl Substituent Dictates the Pathway of a Concerted Electrocyclic Ring-Opening of Cyclobutene

ChemInform, 2003-04, Vol.34 (14), p.no-no

2003

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ChemInform Abstract: Stereoselective Synthesis of Isomeric Functionalized 1,3-Dienes from Cyclobutenones

ChemInform, 2001-10, Vol.32 (41), p.no-no

2001

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Design and Identification of a GPR40 Full Agonist (SCO-267) Possessing a 2‑Carbamoylphenyl Piperidine Moiety

GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve

Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554

A Silyl Substituent Can Dictate a Concerted Electrocyclic Pathway: Inward Torquoselectivity in the Ring Opening of 3-Silyl-1-cyclobutene

Stereoselective Synthesis of Isomeric Functionalized 1,3-Dienes from Cyclobutenones

SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control in Rat Models of Diabetes and Obesity

Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor

Torque control by metal-orbital interactions

Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

1161-P: SCO-267, a GPR40 Full Agonist, Improves Glycemic and Body Weight Control More Than That by Fasiglifam in Rat Models of Diabetes and Obesity

Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes

Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor

Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554

A Silyl Substituent Dictates the Pathway of a Concerted Electrocyclic Ring-opening of Cyclobutene

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Corrigendum to “Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554” [Bioorg. Med. Chem. 19 (2011) 4482–4498]

Ein Silylsubstituent steuert eine elektrocyclische Reaktion: Stereoselektivität bei der Ringöffnung von 3-Silyl-1-cyclobuten

Effect of Hyperglycemia and Hypoglycemia on the Myo-inositol Content in Various Nerve Tissues of Rats

Successful resection of pheochromocytoma in a hemodialysis patient

Ein Silylsubstituent steuert eine elektrocyclische Reaktion: Stereoselektivität bei der Ringöffnung von 3‐Silyl‐1‐cyclobuten

Airway Basophil and Mast Cell Density in Patients with Bronchial Asthma: Relationship to Bronchial Hyperresponsiveness

The Myo-Inositol Content of Various Nerve Tissues from Streptozotocin-Diabetic Rats

A Silyl Substituent Dictates the Pathway of a Concerted Electrocyclic Ring-Opening of Cyclobutene

ChemInform Abstract: Stereoselective Synthesis of Isomeric Functionalized 1,3-Dienes from Cyclobutenones

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