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Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Cancer cell, 2014-05, Vol.25 (5), p.697-710

2014

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Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Chemical and Pharmaceutical Bulletin, 2016/11/01, Vol.64(11), pp.1622-1629

2016

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Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers

Cancer science, 2012-02, Vol.103 (2), p.342-349

2012

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Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors

Bioorganic & medicinal chemistry letters, 2012-01, Vol.22 (2), p.1136-1141

2012

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Autonomous Motion of Vesicle via Ion Exchange

Langmuir, 2010-02, Vol.26 (3), p.1610-1618

2010

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Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Chemical and Pharmaceutical Bulletin, 2016-11, Vol.64 (11), p.1622-1629

2016

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Establishment of standard values for the latency, interval and amplitude parameters of tibial nerve somatosensory evoked potentials (SEPs)

Clinical neurophysiology, 2003-07, Vol.114 (7), p.1367-1378

2003

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Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Cancer research (Chicago, Ill.), 2013-07, Vol.73 (13), p.4050-4060

2013

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Fragment Screening Using Surface Plasmon Resonance Optical Biosensor Technology

YAKUGAKU ZASSHI, 2010/03/01, Vol.130(3), pp.341-348

MIURA, Takaaki

2010

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Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors

Bioorganic & medicinal chemistry, 2014-01, Vol.22 (2), p.892-905

2014

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Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

Bioorganic & medicinal chemistry, 2016-09, Vol.24 (18), p.4206-4217

2016

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Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1031-1036

2017

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Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors

Bioorganic & medicinal chemistry letters, 2012-12, Vol.22 (24), p.7486-7489

2012

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Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Bioorganic & medicinal chemistry letters, 2011-03, Vol.21 (6), p.1795-1801

2011

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Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (19), p.5778-5783

2011

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Abstract 4758: Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4758-4758

2014

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Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution 1 1Edited by P. E. Wright

Journal of molecular biology, 1999-07, Vol.290 (1), p.213-228

1999

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γ-セクレターゼの三次元構造

ファルマシア, 2015, Vol.51(3), pp.254-254

三浦, 隆昭

2015

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Near-field optical microscopy of AlGaInP laser diode emissions and comparison with far-field observation

Colloids and surfaces. A, Physicochemical and engineering aspects, 2008-02, Vol.313-314, p.474-478

2008

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Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution

Journal of molecular biology, 1999-07, Vol.290 (1), p.213-228

1999

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Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF

Cancer research (Chicago, Ill.), 2011-04, Vol.71 (8_Supplement), p.3606-3606

2011

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Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII

Journal of biomolecular NMR, 2003-11, Vol.27 (3), p.279-280

2003

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表面プラズモン共鳴装置を用いたフラグメントスクリーニング

YAKUGAKU ZASSHI, 2010/03/01, Vol.130(3), pp.341-348

三浦, 隆昭

2010

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ChemInform Abstract: Fragment Screening Using Surface Plasmon Resonance Optical Biosensor Technology

ChemInform, 2010-07, Vol.41 (27), p.no-no

Miura, Takaaki

2010

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Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Preclinical antitumor activity of the novel heat shock protein 90 inhibitor CH5164840 against human epidermal growth factor receptor 2 (HER2)‐overexpressing cancers

Design and synthesis of novel macrocyclic 2-amino-6-arylpyrimidine Hsp90 inhibitors

Autonomous Motion of Vesicle via Ion Exchange

Development of a Method for Converting a TAK1 Type I Inhibitor into a Type II or c-Helix-Out Inhibitor by Structure-Based Drug Design (SBDD)

Establishment of standard values for the latency, interval and amplitude parameters of tibial nerve somatosensory evoked potentials (SEPs)

Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity

Fragment Screening Using Surface Plasmon Resonance Optical Biosensor Technology

Design and synthesis of 2-amino-6-(1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel Hsp90 inhibitors

Discovery of a potent and highly selective transforming growth factor β receptor-associated kinase 1 (TAK1) inhibitor by structure based drug design (SBDD)

Identification of a selective inhibitor of transforming growth factor β-activated kinase 1 by biosensor-based screening of focused libraries

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors

Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent

Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design

Abstract 4758: Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution 1 1Edited by P. E. Wright

γ-セクレターゼの三次元構造

Near-field optical microscopy of AlGaInP laser diode emissions and comparison with far-field observation

Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution

Abstract 3606: CH5126766 is a novel allosteric inhibitor of MEK that prevents its phosphorylation by RAF

Backbone resonance assignment of human eukaryotic translation initiation factor 4E (eIF4E) in complex with 7-methylguanosine diphosphate (m7GDP) and a 17-amino acid peptide derived from human eIF4GII

表面プラズモン共鳴装置を用いたフラグメントスクリーニング

ChemInform Abstract: Fragment Screening Using Surface Plasmon Resonance Optical Biosensor Technology

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