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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Frontiers in genetics, 2019-01, Vol.9, p.636-636

2019

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Potential functional and pathological side effects related to off-target pharmacological activity

Journal of pharmacological and toxicological methods, 2017-09, Vol.87, p.108-126

2017

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Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Frontiers in big data, 2019-07, Vol.2, p.25

2019

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Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.74-80

2011

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Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

Toxicological sciences, 2024-03, Vol.198 (2), p.316-327

2024

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Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster

The Journal of pharmacology and experimental therapeutics, 2009-08, Vol.330 (2), p.526

2009

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Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1751-1757

2012

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Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Journal of pharmacological and toxicological methods, 2024-03, Vol.126, p.107497-107497, Article 107497

2024

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Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies

Journal of pharmacological and toxicological methods, 2020-01, Vol.101, p.106653-106653, Article 106653

2020

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Off-target pharmacological activity at various kinases: Potential functional and pathological side effects

Journal of pharmacological and toxicological methods, 2023-09, Vol.123, p.107468-107468, Article 107468

2023

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-05, Vol.109, p.107066-107066, Article 107066

2021

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Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Comparative medicine, 2021-04, Vol.71 (2), p.133-140

2021

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Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Journal of pharmacological and toxicological methods, 2021-11, Vol.112, p.107115-107115, Article 107115

2021

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Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.107109-107109, Article 107109

2021

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The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs

Journal of pharmacological and toxicological methods, 2018-05, Vol.91, p.27-35

2018

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Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106580-106580, Article 106580

2019

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Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

Journal of pharmacological and toxicological methods, 2020-05, Vol.103, p.106871, Article 106871

2020

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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Journal of pharmacological and toxicological methods, 2017-05, Vol.85, p.1-21

2017

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The proconvulsant effects of leptin on glutamate receptor-mediated seizures in mice

Brain research bulletin, 2010-04, Vol.82 (1), p.99-103

2010

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An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Journal of pharmacological and toxicological methods, 2017-05, Vol.85, p.1-21

2017

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In vivo efficacy of acyl CoA: Diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia

European journal of pharmacology, 2010-07, Vol.637 (1), p.155-161

2010

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Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

Blood coagulation & fibrinolysis, 2012-01, Vol.23 (1), p.94-97

2012

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Spontaneous locomotor activity assessment: Cage crossings are more important than total number of beam breaks

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e19-e19

2011

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Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

Journal of cardiovascular pharmacology, 2009-12, Vol.54 (6), p.543-551

2009

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Differential effects of fenfluramine in regulating pulmonary and systemic circulation

Journal of pharmacological and toxicological methods, 2011-07, Vol.64 (1), p.e4-e5

2011

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Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies

Potential functional and pathological side effects related to off-target pharmacological activity

Novel Computational Approach to Predict Off-Target Interactions for Small Molecules

Comparison of methods for the assessment of locomotor activity in rodent safety pharmacology studies

Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors

Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the Zucker fatty rat and the hyperlipidemic hamster

Identification and Preliminary Characterization of a Potent, Safe, and Orally Efficacious Inhibitor of Acyl-CoA:Diacylglycerol Acyltransferase 1

Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog

Refinement of the rodent pentylenetetrazole proconvulsion assay, which is a good predictor of convulsions in repeat-dose toxicology studies

Off-target pharmacological activity at various kinases: Potential functional and pathological side effects

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

Automated Blood Sampling in a Canine Telemetry Cardiovascular Model

Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities

Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins

The evaluation of drug-induced changes in left ventricular function in pentobarbital-anesthetized dogs

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

Drug-induced QT prolongation: Concordance of preclinical anesthetized canine model in relation to published clinical observations for ten CiPA drugs

An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

The proconvulsant effects of leptin on glutamate receptor-mediated seizures in mice

An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

In vivo efficacy of acyl CoA: Diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia

Capsaicin-induced inhibition of platelet aggregation is not mediated by transient receptor potential vanilloid type 1

Spontaneous locomotor activity assessment: Cage crossings are more important than total number of beam breaks

Cardiovascular Effects of Torcetrapib in Conscious and Pentobarbital-anesthetized Dogs

Differential effects of fenfluramine in regulating pulmonary and systemic circulation

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