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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

Nature (London), 2016-01, Vol.529 (7587), p.541-545

2016

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X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

PloS one, 2016-04, Vol.11 (4), p.e0154190-e0154190

2016

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Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation

Journal of virology, 2020-12, Vol.95 (2)

2020

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Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase

European journal of medicinal chemistry, 2018-05, Vol.152, p.160-174

2018

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Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition

Angewandte Chemie International Edition, 2018-07, Vol.57 (27), p.8002-8006

International ed. in English, 2018

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High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression

Journal of virology, 2022-05, Vol.96 (10), p.e0187521

2022

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Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

Journal of medicinal chemistry, 2019-09, Vol.62 (17), p.8164-8177

2019

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Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

Nature, 2003-11, Vol.426 (6962), p.91-96

2003

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Conformational editing of intrinsically disordered protein by α-methylation

Chemical science (Cambridge), 2021-01, Vol.12 (3), p.18-189

2021

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Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

Proteins, structure, function, and bioinformatics, 2016-01, Vol.84 (1), p.129-142

2016

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Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

Human molecular genetics, 2013-10, Vol.22 (20), p.4215-4223

2013

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New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Acta crystallographica. Section D, Biological crystallography., 2015-07, Vol.71 (7), p.1455-1470

2015

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Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

Acta crystallographica. Section D, Biological crystallography., 2014-03, Vol.70 (3), p.889-903

2014

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Molecular Recognition of Agonist Ligands by RXRs

Molecular endocrinology (Baltimore, Md.), 2002-05, Vol.16 (5), p.987-997

2002

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Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

Chemico-biological interactions, 2015-06, Vol.234, p.290-296

2015

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Neutron macromolecular crystallography with LADI-III

Acta crystallographica. Section D, Biological crystallography., 2010-11, Vol.66 (11), p.1198-1205

2010

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Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants

Scientific reports, 2017-02, Vol.7 (1), p.42343-42343, Article 42343

2017

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Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008

Chemico-biological interactions, 2017-10, Vol.276, p.174-181

2017

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The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

Biochimica et biophysica acta, 2016-06, Vol.1864 (6), p.655-666

2016

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Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning

ACS chemical biology, 2013-11, Vol.8 (11), p.2484-2492

2013

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Crystal packing modifies ligand binding affinity: The case of aldose reductase

Proteins, structure, function, and bioinformatics, 2012-11, Vol.80 (11), p.2552-2561

2012

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Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

Journal of medicinal chemistry, 2018-02, Vol.61 (3), p.695-710

2018

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The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

ACS chemical biology, 2015-07, Vol.10 (7), p.1637-1642

2015

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X-ray-induced deterioration of disulfide bridges at atomic resolution

Acta crystallographica. Section D, Biological crystallography., 2010-10, Vol.66 (10), p.1075-1091

2010

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Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

Journal of medicinal chemistry, 2013-03, Vol.56 (6), p.2568-2580

2013

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Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

X-Ray Crystal Structure of the Full Length Human Chitotriosidase (CHIT1) Reveals Features of Its Chitin Binding Domain

Structure of High-Risk Papillomavirus 31 E6 Oncogenic Protein and Characterization of E6/E6AP/p53 Complex Formation

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase

Structural Basis of Outstanding Multivalent Effects in Jack Bean α‐Mannosidase Inhibition

High-Risk Mucosal Human Papillomavirus 16 (HPV16) E6 Protein and Cutaneous HPV5 and HPV8 E6 Proteins Employ Distinct Strategies To Interfere with Interferon Regulatory Factor 3-Mediated Beta Interferon Expression

Discovery of N‑Substituted 3‑Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

Conformational editing of intrinsically disordered protein by α-methylation

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

Linear and extended: a common polyglutamine conformation recognized by the three antibodies MW1, 1C2 and 3B5H10

New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM

Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design

Molecular Recognition of Agonist Ligands by RXRs

Structural analysis of sulindac as an inhibitor of aldose reductase and AKR1B10

Neutron macromolecular crystallography with LADI-III

Structural variability of E. coli thioredoxin captured in the crystal structures of single-point mutants

Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008

The role of the C-terminal region on the oligomeric state and enzymatic activity of Trypanosoma cruzi hypoxanthine phosphoribosyl transferase

Modulation of Aldose Reductase Inhibition by Halogen Bond Tuning

Crystal packing modifies ligand binding affinity: The case of aldose reductase

Targeting Acidic Mammalian chitinase Is Effective in Animal Model of Asthma

The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition

X-ray-induced deterioration of disulfide bridges at atomic resolution

Discovery of (R)‑2-Amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic Acid and Congeners As Highly Potent Inhibitors of Human Arginases I and II for Treatment of Myocardial Reperfusion Injury

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