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hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

Chemical research in toxicology, 2008-05, Vol.21 (5), p.1005-1010

Mitcheson, John S

2008

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Predicting drug–hERG channel interactions that cause acquired long QT syndrome

Trends in pharmacological sciences (Regular ed.), 2005-03, Vol.26 (3), p.119-124

2005

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A Structural Basis for Drug-Induced Long QT Syndrome

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (22), p.12329-12333

2000

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A mechanism for CO regulation of ion channels

Nature communications, 2018-03, Vol.9 (1), p.907-10, Article 907

2018

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Molecular Determinants of hERG Channel Block

Molecular pharmacology, 2006-05, Vol.69 (5), p.1709-1716

2006

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A heme-binding domain controls regulation of ATP-dependent potassium channels

Proceedings of the National Academy of Sciences - PNAS, 2016-04, Vol.113 (14), p.3785-3790

2016

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A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6

Biochemistry (Easton), 2018-05, Vol.57 (18), p.2611-2622

2018

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Modulation of hERG potassium channels by a novel small molecule activator

British journal of pharmacology, 2017-10, Vol.174 (20), p.3669-3671

2017

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Author Correction: A mechanism for CO regulation of ion channels

Nature communications, 2018-08, Vol.9 (1), p.3354-1, Article 3354

2018

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Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

The Journal of biological chemistry, 2011-02, Vol.286 (8), p.6184-6191

2011

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hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Journal of the American Heart Association, 2015-04, Vol.4 (4)

2015

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Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

The Journal of biological chemistry, 2020-09, Vol.295 (38), p.13277-13286

2020

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Drug block of the hERG potassium channel: Insight from modeling

Proteins, structure, function, and bioinformatics, 2007-08, Vol.68 (2), p.568-580

2007

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Correction: Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

The Journal of biological chemistry, 2022-03, Vol.298 (3), p.101754-101754, Article 101754

2022

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Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain

The Journal of biological chemistry, 2016-08, Vol.291 (34), p.17907-17918

2016

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New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity

Molecular pharmacology, 2015-02, Vol.87 (2), p.183

2015

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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate

The Journal of general physiology, 2000-03, Vol.115 (3), p.229-240

2000

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Drug binding to HERG channels: evidence for a ‘non‐aromatic’ binding site for fluvoxamine

British journal of pharmacology, 2003-07, Vol.139 (5), p.883-884

Mitcheson, John S

2003

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Computational Design and Discovery of “Minimally Structured” hERG Blockers

Journal of medicinal chemistry, 2012-04, Vol.55 (8), p.4010-4014

2012

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Structural Determinants of HERG Channel Block by Clofilium and Ibutilide

Molecular pharmacology, 2004-08, Vol.66 (2), p.240-249

2004

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Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Molecular pharmacology, 2006-02, Vol.69 (2), p.509-519

2006

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hERG potassium channel inhibition by ivabradine requires channel gating

Journal of molecular and cellular cardiology, 2015-10, Vol.87, p.126-128

2015

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Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels

Molecular pharmacology, 2014-08, Vol.86 (2), p.211-221

2014

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The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping

Molecular pharmacology, 2004-11, Vol.66 (5), p.1201-1212

2004

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Activation Gating of hERG Potassium Channels: S6 GLYCINES ARE NOT REQUIRED AS GATING HINGES

The Journal of biological chemistry, 2007-11, Vol.282 (44), p.31972-31981

2007

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hERG Potassium Channels and the Structural Basis of Drug-Induced Arrhythmias

Predicting drug–hERG channel interactions that cause acquired long QT syndrome

A Structural Basis for Drug-Induced Long QT Syndrome

A mechanism for CO regulation of ion channels

Molecular Determinants of hERG Channel Block

A heme-binding domain controls regulation of ATP-dependent potassium channels

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6

Modulation of hERG potassium channels by a novel small molecule activator

Author Correction: A mechanism for CO regulation of ion channels

Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Drug block of the hERG potassium channel: Insight from modeling

Correction: Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain

New pyrimido-indole compound CD-160130 preferentially inhibits the KV11.1B isoform and produces antileukemic effects without cardiotoxicity

Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate

Drug binding to HERG channels: evidence for a ‘non‐aromatic’ binding site for fluvoxamine

Computational Design and Discovery of “Minimally Structured” hERG Blockers

Structural Determinants of HERG Channel Block by Clofilium and Ibutilide

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

hERG potassium channel inhibition by ivabradine requires channel gating

Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels

The low-potency, voltage-dependent HERG blocker propafenone--molecular determinants and drug trapping

Activation Gating of hERG Potassium Channels: S6 GLYCINES ARE NOT REQUIRED AS GATING HINGES

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