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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Journal of medicinal chemistry, 2012-09, Vol.55 (18), p.8110-8127

2012

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Discovery of pyrrolopyrimidine inhibitors of Akt

Bioorganic & medicinal chemistry letters, 2010-10, Vol.20 (19), p.5607-5612

2010

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Discovery and SAR of spirochromane Akt inhibitors

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2410-2414

2011

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Bioorganic & medicinal chemistry letters, 2010-12, Vol.20 (23), p.7037-7041

2010

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PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors

Haemophilia : the official journal of the World Federation of Hemophilia, 2021-11, Vol.27 (6), p.911-920

2021

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Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors

Haemophilia : the official journal of the World Federation of Hemophilia, 2022-07, Vol.28 (4), p.548-556

2022

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MR imaging-guided radio-frequency thermal ablation of the lumbar vertebrae in porcine models

Radiology, 2002-08, Vol.224 (2), p.452-462

2002

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Experience performing 64 consecutive stapled intestinal anastomoses in small children and infants

Journal of pediatric surgery, 2011, Vol.46 (1), p.128-130

2011

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Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors

Blood, 2022-11, Vol.140 (Supplement 1), p.8485-8488

2022

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PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhibitors

Blood, 2020-11, Vol.136 (Supplement 1), p.34-36

2020

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In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors

Blood, 2020-11, Vol.136 (Supplement 1), p.41-42

2020

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Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEPT1 Subset Analysis

Blood, 2020-11, Vol.136 (Supplement 1), p.2-3

2020

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Synthesis of 3-methylindoles from N-aryl- N-(3-triisopropylsilylpropargyl)sulfonamides

Tetrahedron letters, 1998-06, Vol.39 (26), p.4595-4598

1998

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Tradition and Innovation in English Retailing, 1700 to 1850: Narratives of Consumption

Mitchell, Ian

1, 2014

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Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

The New England journal of medicine, 2022-03, Vol.386 (9), p.837-846

2022

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Retail and Community: Business, Charity and the End of Empire

1, 2024

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HTRS2023.O8C.2 Eptacog beta efficacy and safety in underweight, normal weight, and overweight/obese persons with hemophilia A or B and inhibitors

Research and practice in thrombosis and haemostasis, 2023-08, Vol.7, p.100219, Article 100219

2023

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Evaluating DEER Distance Profiles in Terms of Protein Conformational Ensembles

Biophysical journal, 2014-01, Vol.106 (2), p.456a-456a

2014

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Privacy, Security and Forensics in the Internet of Things (IoT)

1, 2022

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Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants

The New England journal of medicine, 2023-04, Vol.388 (16), p.1533-1534

2023

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The Psychology of Soccer

1, 2020

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A Hybrid Reasoning Model for “Whole and Part” Cardinal Direction Relations

Advances in artificial intelligence, 2013-01, Vol.2013 (2013), p.1-20

2013

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Prioritising respiratory syncytial virus prevention in low-income and middle-income countries

The Lancet global health, 2023-05, Vol.11 (5), p.e655-e657

2023

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Serious Adverse Events in the Canadian Registry of Children Receiving Palivizumab (CARESS) for Respiratory Syncytial Virus Prevention

PloS one, 2015-08, Vol.10 (8), p.e0134711

2015

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Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery and SAR of spirochromane Akt inhibitors

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors

Eptacog beta efficacy and safety in the treatment and control of bleeding in paediatric subjects (<12 years) with haemophilia A or B with inhibitors

MR imaging-guided radio-frequency thermal ablation of the lumbar vertebrae in porcine models

Experience performing 64 consecutive stapled intestinal anastomoses in small children and infants

Eptacog Beta (rFVIIa) Has a Low Incidence of Spontaneous Rebleeding through 24 and 48 Hours in Adult and Adolescent Patients with Hemophilia A or B with Inhibitors

PERSEPT3: A Phase 3 Clinical Trial to Evaluate the Hemostatic Efficacy of Eptacog Beta (Recombinant Human FVIIa) in Perioperative Care in Subjects with Hemophilia Α or B with Inhibitors

In Vitro Evaluation of Thrombin Generation of Eptacog Beta (Factor VIIa, Recombinant) and Emicizumab in Congenital Hemophilia Α Plasma with and without Inhibitors

Single 225μg/Kg Dose Treatment with Eptacog Beta (Factor VIIa, Recombinant) Results in Rapid Hemostasis in Joint Bleeds for Persons with Hemophilia Α or Β with Inhibitors: A PERSEPT1 Subset Analysis

Synthesis of 3-methylindoles from N-aryl- N-(3-triisopropylsilylpropargyl)sulfonamides

Tradition and Innovation in English Retailing, 1700 to 1850: Narratives of Consumption

Eptacog Beta Efficacy in Children and Adolescents with Hemophilia A or B and Inhibitors: Subset Analysis Suggests Improved Caregiver Capacity to Assess Bleeding Episode Resolution with Subject Age

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Retail and Community: Business, Charity and the End of Empire

HTRS2023.O8C.2 Eptacog beta efficacy and safety in underweight, normal weight, and overweight/obese persons with hemophilia A or B and inhibitors

Evaluating DEER Distance Profiles in Terms of Protein Conformational Ensembles

Privacy, Security and Forensics in the Internet of Things (IoT)

Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants

The Psychology of Soccer

A Hybrid Reasoning Model for “Whole and Part” Cardinal Direction Relations

Prioritising respiratory syncytial virus prevention in low-income and middle-income countries

Serious Adverse Events in the Canadian Registry of Children Receiving Palivizumab (CARESS) for Respiratory Syncytial Virus Prevention

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