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Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Pharmacology, biochemistry and behavior, 2017-04, Vol.155, p.43-55

2017

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Peptides that Regulate Food Intake: Antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization

American journal of physiology. Regulatory, integrative and comparative physiology, 2003-06, Vol.284 (6), p.1399-R1408

2003

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Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists

European journal of pharmacology, 2004-06, Vol.494 (2), p.121-130

2004

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Localization of opioid receptor antagonist [ 3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites

Neuropeptides (Edinburgh), 2005-12, Vol.39 (6), p.559-567

2005

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Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

The Journal of pharmacology and experimental therapeutics, 1999-08, Vol.290 (2), p.901

1999

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Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Journal of medicinal chemistry, 1992-06, Vol.35 (12), p.2274-2283

1992

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Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects

Brain research, 1998-06, Vol.795 (1), p.179-190

1998

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Potential role of muscarinic receptors in schizophrenia

Life sciences (1973), 1999, Vol.64 (6), p.527-534

1999

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Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

European journal of pharmacology, 1998-09, Vol.356 (2), p.109-119

1998

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The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from chinese hamster ovary-m1 cells

Life sciences (1973), 1995, Vol.57 (12), p.1183-1190

1995

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Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.876

1997

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Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Journal of medicinal chemistry, 1997-02, Vol.40 (4), p.538-546

1997

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Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity

The Journal of pharmacology and experimental therapeutics, 1997-05, Vol.281 (2), p.884

1997

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3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Journal of medicinal chemistry, 1993-10, Vol.36 (20), p.2842-2850

1993

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Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones

Journal of medicinal chemistry, 1992-09, Vol.35 (18), p.3319-3324

1992

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Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4011-4019

1992

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A cyanide promoted Michael reaction: the use of an aminonitrile as an enamine equivalent for the Michael reaction

Tetrahedron letters, 1988, Vol.29 (52), p.6831-6834

MITCH, C. H

1988

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In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist

Life sciences (1973), 1997, Vol.60 (13), p.969-976

1997

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3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors

European journal of medicinal chemistry, 1996, Vol.31 (3), p.221-230

1996

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The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat

International journal of obesity, 1991-06, Vol.15 (6), p.387

1991

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Studies directed towards the total synthesis of morphine alkaloids

Tetrahedron letters, 1982, Vol.23 (3), p.285-288

1982

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Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists

Psychopharmacology, 1995-01, Vol.117 (2), p.208-215

1995

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Synthesis and structural determination of stereoisomers of muscarinic ligands of the (3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicycloalkane type

Chirality (New York, N.Y.), 1997, Vol.9 (8), p.739-749

1997

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Synthesis and absolute configuration of LY255582, a potent opioid antagonist

Journal of organic chemistry, 1991-02, Vol.56 (4), p.1660-1663

1991

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Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres

Biochemical and biophysical research communications, 1992-09, Vol.187 (3), p.1389-1394

1992

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Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

Peptides that Regulate Food Intake: Antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization

Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists

Localization of opioid receptor antagonist [ 3H]-LY255582 binding sites in mouse brain: Comparison with the distribution of mu, delta and kappa binding sites

Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats

Novel functional M1 selective muscarinic agonists. Synthesis and structure-activity relationships of 3-(1,2,5-thiadiazolyl)-1,2,5,6-tetrahydro-1-methylpyridines

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects

Potential role of muscarinic receptors in schizophrenia

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5 R,6 R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

The muscarinic M1 agonist xanomeline increases soluble amyloid precursor protein release from chinese hamster ovary-m1 cells

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic

Muscarinic Analgesics with Potent and Selective Effects on the Gastrointestinal Tract: Potential Application for the Treatment of Irritable Bowel Syndrome

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Synthesis and excitatory amino acid pharmacology of a series of heterocyclic-fused quinoxalinones and quinazolinones

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore

A cyanide promoted Michael reaction: the use of an aminonitrile as an enamine equivalent for the Michael reaction

In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist

3-(3-Alkylthio-1,2,5-thiadiazol-4-yl)-1-azabicycles. Structure—activity relationships for antinociception mediated by central muscarinic receptors

The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat

Studies directed towards the total synthesis of morphine alkaloids

Novel alkoxy-oxazolyl-tetrahydropyridine muscarinic cholinergic receptor antagonists

Synthesis and structural determination of stereoisomers of muscarinic ligands of the (3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicycloalkane type

Synthesis and absolute configuration of LY255582, a potent opioid antagonist

Steric and electronic requirements for muscarinic receptor-stimulated phosphoinositide turnover in the CNS in a series of arecoline bioisosteres

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