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On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

The Journal of biological chemistry, 2020-03, Vol.295 (13), p.4134-4170

2020

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Replication Fork Stalling at Natural Impediments

Microbiology and Molecular Biology Reviews, 2007-03, Vol.71 (1), p.13-35

2007

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At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

Genes, 2019-02, Vol.10 (2), p.118

2019

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The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

Nature structural & molecular biology, 2017-01, Vol.24 (1), p.55-60

2017

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Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements

PLoS genetics, 2023-01, Vol.19 (1), p.e1010590-e1010590

2023

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Discovery of alternative DNA structures: a heroic decade (1979-1989)

Frontiers in bioscience, 2008-01, Vol.13 (13), p.1064

Mirkin, Sergei M

2008

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Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers

Nucleic acids research, 2023-09, Vol.51 (16), p.8532-8549

2023

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Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

Proceedings of the National Academy of Sciences - PNAS, 2008-07, Vol.105 (29), p.9936-9941

2008

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Mechanisms of genetic instability caused by (CGG) n repeats in an experimental mammalian system

Nature structural & molecular biology, 2018-08, Vol.25 (8), p.669-676

2018

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RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication

Nucleic acids research, 2018-04, Vol.46 (7), p.3487-3497

2018

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Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures

Nucleic acids research, 2024-05, Vol.52 (8), p.4361-4374

2024

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Expandable DNA repeats and human disease

Nature, 2007-06, Vol.447 (7147), p.932-940

Mirkin, Sergei M

2007

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Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes

Scientific reports, 2022-01, Vol.12 (1), p.591-591, Article 591

2022

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To Switch or Not to Switch: At the Origin of Repeat Expansion Disease

Molecular cell, 2014-01, Vol.53 (1), p.1-3

2014

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Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability

Nature communications, 2017-06, Vol.8 (1), p.15855-15855, Article 15855

2017

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Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Genome research, 2017-12, Vol.27 (12), p.2072-2082

2017

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Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

Molecular cell, 2012-10, Vol.48 (2), p.254-265

2012

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Mechanisms of Transcription-Replication Collisions in Bacteria

Molecular and Cellular Biology, 2005-02, Vol.25 (3), p.888-895

2005

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Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

Proceedings of the National Academy of Sciences - PNAS, 2010-07, Vol.107 (29), p.12816-12821

2010

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Genome rearrangements caused by interstitial telomeric sequences in yeast

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (49), p.19866-19871

2013

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Replication Stalling at Friedreich's Ataxia (GAA)n Repeats In Vivo

Molecular and Cellular Biology, 2004-03, Vol.24 (6), p.2286-2295

2004

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Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

Nature structural & molecular biology, 2009-02, Vol.16 (2), p.226-228

2009

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Overcoming natural replication barriers: differential helicase requirements

Nucleic acids research, 2012-02, Vol.40 (3), p.1091-1105

2012

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Role of DNA Polymerases in Repeat-Mediated Genome Instability

Cell reports (Cambridge), 2012-11, Vol.2 (5), p.1088-1095

2012

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Transcription blockage by stable H-DNA analogs in vitro

Nucleic acids research, 2015-08, Vol.43 (14), p.6994-7004

2015

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On the wrong DNA track: Molecular mechanisms of repeat-mediated genome instability

Replication Fork Stalling at Natural Impediments

At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

The role of break-induced replication in large-scale expansions of (CAG) n /(CTG) n repeats

Shuffling the yeast genome using CRISPR/Cas9-generated DSBs that target the transposable Ty1 elements

Discovery of alternative DNA structures: a heroic decade (1979-1989)

Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

Mechanisms of genetic instability caused by (CGG) n repeats in an experimental mammalian system

RNA–DNA hybrids promote the expansion of Friedreich's ataxia (GAA)n repeats via break-induced replication

Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures

Expandable DNA repeats and human disease

Characteristics and possible mechanisms of formation of microinversions distinguishing human and chimpanzee genomes

To Switch or Not to Switch: At the Origin of Repeat Expansion Disease

Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability

Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

Mechanisms of Transcription-Replication Collisions in Bacteria

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

Genome rearrangements caused by interstitial telomeric sequences in yeast

Replication Stalling at Friedreich's Ataxia (GAA)n Repeats In Vivo

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

Overcoming natural replication barriers: differential helicase requirements

Role of DNA Polymerases in Repeat-Mediated Genome Instability

Transcription blockage by stable H-DNA analogs in vitro

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