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The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug Clearance

Clinical pharmacology and therapeutics, 2017-09, Vol.102 (3), p.436-449

2017

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Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

British journal of clinical pharmacology, 1998-06, Vol.45 (6), p.525-538

1998

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Haemodynamic effects of parenteral vs. enteral paracetamol in critically ill patients: a randomised controlled trial

Anaesthesia, 2016-10, Vol.71 (10), p.1153-1162

2016

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Electrochemical characterisation of the human cytochrome P450 CYP2C9

Biochemical pharmacology, 2005-05, Vol.69 (10), p.1533-1541

2005

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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

The Journal of pharmacology and experimental therapeutics, 2001-12, Vol.299 (3), p.998

2001

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The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

British journal of clinical pharmacology, 2001-11, Vol.52 (5), p.605-609

2001

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Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

The Journal of pharmacology and experimental therapeutics, 1993-04, Vol.265 (1), p.401

1993

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Nonspecific binding of drugs to human liver microsomes

British journal of clinical pharmacology, 2000-05, Vol.49 (5), p.453-461

2000

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Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs

The Journal of pharmacology and experimental therapeutics, 1993-01, Vol.264 (1), p.475

1993

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Polymorphic hydroxylation of perhexiline in vitro

British journal of clinical pharmacology, 2003-06, Vol.55 (6), p.635-638

2003

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Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases

Journal of molecular graphics & modelling, 2004-07, Vol.22 (6), p.507-517

2004

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Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

Biochemical journal, 1993-01, Vol.289 (2), p.533-538

1993

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Drug glucuronidation in humans

Pharmacology & therapeutics (Oxford), 1991, Vol.51 (3), p.347-369

1991

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Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism

British journal of clinical pharmacology, 1994-06, Vol.37 (6), p.597-604

1994

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Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms

British journal of clinical pharmacology, 1994-08, Vol.38 (2), p.131-137

1994

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cDNA Cloning and Expression of Two New Members of the Human Liver UDP-Glucuronosyltransferase 2B Subfamily

Biochemical and biophysical research communications, 1993-07, Vol.194 (1), p.496-503

1993

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Caffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms

Biochemical pharmacology, 1994-05, Vol.47 (10), p.1767-1776

1994

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Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

British journal of clinical pharmacology, 1993-12, Vol.36 (6), p.521-530

1993

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Evidence for involvement of human CYP3A in the 3‐hydroxylation of quinine

British journal of clinical pharmacology, 1997-03, Vol.43 (3), p.245-252

1997

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Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9

Xenobiotica, 2004, Vol.34 (1), p.49-60

2004

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Pharmacodynamics of oxypurinol after administration of allopurinol to healthy subjects

British journal of clinical pharmacology, 1996-04, Vol.41 (4), p.299-304

1996

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Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism

The Journal of pharmacology and experimental therapeutics, 1995-03, Vol.272 (3), p.1076

1995

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Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen

Biochemical pharmacology, 1996-04, Vol.51 (8), p.1003-1008

1996

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Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis

Archives of biochemistry and biophysics, 2007-12, Vol.468 (1), p.58-69

2007

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In silico insights: Chemical and structural characteristics associated with uridine diphosphate-glucuronosyltransferase substrate selectivity

Clinical and experimental pharmacology & physiology, 2003-11, Vol.30 (11), p.836-840

2003

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The Role of the Kidney in Drug Elimination: Transport, Metabolism, and the Impact of Kidney Disease on Drug Clearance

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

Haemodynamic effects of parenteral vs. enteral paracetamol in critically ill patients: a randomised controlled trial

Electrochemical characterisation of the human cytochrome P450 CYP2C9

Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms

The glucuronidation of mycophenolic acid by human liver, kidney and jejunum microsomes

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2

Nonspecific binding of drugs to human liver microsomes

Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs

Polymorphic hydroxylation of perhexiline in vitro

Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases

Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily

Drug glucuronidation in humans

Identification of human liver cytochrome P450 isoforms mediating secondary omeprazole metabolism

Diazepam metabolism by human liver microsomes is mediated by both S‐ mephenytoin hydroxylase and CYP3A isoforms

cDNA Cloning and Expression of Two New Members of the Human Liver UDP-Glucuronosyltransferase 2B Subfamily

Caffeine metabolism by human hepatic cytochromes p450: Contributions of 1A2, 2E1 and 3A isoforms

Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism

Evidence for involvement of human CYP3A in the 3‐hydroxylation of quinine

Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9

Pharmacodynamics of oxypurinol after administration of allopurinol to healthy subjects

Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism

Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R- and S-naproxen

Comparative homology modeling of human cytochrome P4501A1 (CYP1A1) and confirmation of residues involved in 7-ethoxyresorufin O-deethylation by site-directed mutagenesis and enzyme kinetic analysis

In silico insights: Chemical and structural characteristics associated with uridine diphosphate-glucuronosyltransferase substrate selectivity

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