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Current Molecular Combination Therapies Used for the Treatment of Breast Cancer

International journal of molecular sciences, 2022-09, Vol.23 (19), p.11046

2022

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The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment

Cells (Basel, Switzerland), 2021-12, Vol.10 (12), p.3565

2021

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A key role for Pak4 in proliferation and differentiation of neural progenitor cells

Developmental biology, 2011-05, Vol.353 (2), p.206-216

2011

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Inhibition of NAMPT by PAK4 Inhibitors

International journal of molecular sciences, 2024-09, Vol.25 (18), p.10138

2024

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Regulation and function of the JNK subgroup of MAP kinases

Biochimica et biophysica acta, 1997-10, Vol.1333 (2), p.F85-F104

1997

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Death Receptor-Induced Activation of Initiator Caspase 8 Is Antagonized by Serine/Threonine Kinase PAK4

Molecular and Cellular Biology, 2003-11, Vol.23 (21), p.7838-7848

2003

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Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin

The Journal of biological chemistry, 2001-08, Vol.276 (34), p.32115-32121

2001

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The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis

The Journal of biological chemistry, 2001-04, Vol.276 (17), p.14414-14419

2001

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The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

Molecular cancer research, 2008-07, Vol.6 (7), p.1215-1224

2008

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P21 activated kinase signaling in cancer

Seminars in cancer biology, 2019-02, Vol.54, p.40-49

2019

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Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice

PloS one, 2013-04, Vol.8 (4), p.e61321

2013

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Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

Developmental biology, 2008-10, Vol.322 (1), p.95-108

2008

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p120-catenin is a binding partner and substrate for Group B Pak kinases

Journal of cellular biochemistry, 2010-08, Vol.110 (5), p.1244-1254

2010

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Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

Scientific reports, 2017-08, Vol.7 (1), p.7031-7031, Article 7031

2017

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PAK4-6 in cancer and neuronal development

Cellular logistics, 2012-04, Vol.2 (2), p.95-104

Minden, Audrey

2012

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Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

Cell, 1995-06, Vol.81 (7), p.1147-1157

1995

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PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells

Molecular and Cellular Biology, 2002-01, Vol.22 (2), p.567-577

2002

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Targeted Disruption of the Gene for the PAK5 Kinase in Mice

Molecular and Cellular Biology, 2003-10, Vol.23 (20), p.7134-7142

2003

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Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (11), p.4116-4121

2012

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PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

Molecular and Cellular Biology, 2003-10, Vol.23 (20), p.7122-7133

2003

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PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression

Journal of cellular biochemistry, 2011-07, Vol.112 (7), p.1795-1806

2011

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Signaling pathways downstream to receptor tyrosine kinases: targets for cancer treatment

Journal of cancer metastasis and treatment, 2020-11, Vol.2020

2020

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Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth

Molecular and Cellular Biology, 2001-05, Vol.21 (10), p.3523-3533

2001

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Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Science (American Association for the Advancement of Science), 1994-12, Vol.266 (5191), p.1719-1723

1994

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Transforming Activity of the Rho Family GTPase, Wrch-1, a Wnt-regulated Cdc42 Homolog, Is Dependent on a Novel Carboxyl-terminal Palmitoylation Motif

The Journal of biological chemistry, 2005-09, Vol.280 (38), p.33055-33065

2005

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Current Molecular Combination Therapies Used for the Treatment of Breast Cancer

The Use of Nanomedicine to Target Signaling by the PAK Kinases for Disease Treatment

A key role for Pak4 in proliferation and differentiation of neural progenitor cells

Inhibition of NAMPT by PAK4 Inhibitors

Regulation and function of the JNK subgroup of MAP kinases

Death Receptor-Induced Activation of Initiator Caspase 8 Is Antagonized by Serine/Threonine Kinase PAK4

Cytoskeletal Changes Regulated by the PAK4 Serine/Threonine Kinase Are Mediated by LIM Kinase 1 and Cofilin

The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis

The Pak4 Protein Kinase Plays a Key Role in Cell Survival and Tumorigenesis in Athymic Mice

P21 activated kinase signaling in cancer

Functional deficits in PAK5, PAK6 and PAK5/PAK6 knockout mice

Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion

p120-catenin is a binding partner and substrate for Group B Pak kinases

Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development

PAK4-6 in cancer and neuronal development

Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs

PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells

Targeted Disruption of the Gene for the PAK5 Kinase in Mice

Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking

PAK4 Kinase Is Essential for Embryonic Viability and for Proper Neuronal Development

PAK4 is required for regulation of the cell-cycle regulatory protein p21, and for control of cell-cycle progression

Signaling pathways downstream to receptor tyrosine kinases: targets for cancer treatment

Activated PAK4 Regulates Cell Adhesion and Anchorage-Independent Growth

Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK

Transforming Activity of the Rho Family GTPase, Wrch-1, a Wnt-regulated Cdc42 Homolog, Is Dependent on a Novel Carboxyl-terminal Palmitoylation Motif

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