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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

Neuroscience, 2011-12, Vol.198, p.252-273

2011

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Posttranslational modifications & lithium’s therapeutic effect—Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders

Neuroscience and biobehavioral reviews, 2021-08, Vol.127, p.424-445

2021

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Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N

Human molecular genetics, 2015-03, Vol.24 (6), p.1691-1703

2015

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Altered palmitoylation and neuropathological deficits in mice lacking HIP14

Human molecular genetics, 2011-10, Vol.20 (20), p.3899-3909

2011

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Impaired Long-Term Potentiation in the Prefrontal Cortex of Huntington’s Disease Mouse Models: Rescue by D1 Dopamine Receptor Activation

Neuro-degenerative diseases, 2011-05, Vol.8 (4), p.230-239

2011

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Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Neurobiology of disease, 2015-06, Vol.78, p.172-195

2015

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B24 Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease

Journal of neurology, neurosurgery and psychiatry, 2012-09, Vol.83 (Suppl 1), p.A13-A13

2012

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Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

Human molecular genetics, 2012-09, Vol.21 (17), p.3739-3752

2012

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G2019S-LRRK2 Expression Augments -Synuclein Sequestration into Inclusions in Neurons

The Journal of neuroscience, 2016-07, Vol.36 (28), p.7415-7427

2016

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Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease

Human molecular genetics, 2006-05, Vol.15 (10), p.1690-1703

2006

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Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease

Brain research bulletin, 2007-04, Vol.72 (2), p.103-107

2007

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B24Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease

Journal of neurology, neurosurgery and psychiatry, 2012-09, Vol.83 (Suppl 1), p.A13-an-A13

2012

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PATHOPHYSIOLOGY OF HUNTINGTON'S DISEASE: TIME-DEPENDENT ALTERATIONS IN SYNAPTIC AND RECEPTOR FUNCTION: Function and Dysfunction of the Basal Ganglia

Neuroscience, 2011, Vol.198, p.252-273

2011

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Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset

Brain research bulletin, 2007-04, Vol.72 (2), p.98-102

2007

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Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

Journal of Parkinson's disease, 2014, Vol.4 (3), p.483

2014

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Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

Trends in neurosciences (Regular ed.), 2010-11, Vol.33 (11), p.513-523

2010

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Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease

Lancet neurology, 2015-10, Vol.14 (10), p.1054-1064

2015

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A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2

Frontiers in molecular neuroscience, 2020-08, Vol.13, p.153-153

2020

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Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

Neuron (Cambridge, Mass.), 2010-01, Vol.65 (2), p.178-190

2010

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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

The Journal of neuroscience, 2016-07, Vol.36 (28), p.7415-7427

2016

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Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring

Scientific reports, 2024-05, Vol.14 (1), p.10773-10773, Article 10773

2024

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Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Molecular brain, 2021-09, Vol.14 (1), p.143-143, Article 143

2021

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Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

The Journal of physiology, 2007-12, Vol.585 (3), p.817-831

2007

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Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

eLife, 2017-09, Vol.6

2017

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The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation

Cell reports (Cambridge), 2019-11, Vol.29 (8), p.2422-2437.e8

2019

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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function

Posttranslational modifications & lithium’s therapeutic effect—Potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders

Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N

Altered palmitoylation and neuropathological deficits in mice lacking HIP14

Impaired Long-Term Potentiation in the Prefrontal Cortex of Huntington’s Disease Mouse Models: Rescue by D1 Dopamine Receptor Activation

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

B24 Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease

Calpain and STriatal-Enriched protein tyrosine Phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

G2019S-LRRK2 Expression Augments -Synuclein Sequestration into Inclusions in Neurons

Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease

Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease

B24Dysfunctional dopaminergic neurones and biphasic activity-dependent dopamine release in mouse models of Huntington's disease

PATHOPHYSIOLOGY OF HUNTINGTON'S DISEASE: TIME-DEPENDENT ALTERATIONS IN SYNAPTIC AND RECEPTOR FUNCTION: Function and Dysfunction of the Basal Ganglia

Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset

Behavioral deficits and striatal DA signaling in LRRK2 p.G2019S transgenic rats: a multimodal investigation including PET neuroimaging

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

Insights from late-onset familial parkinsonism on the pathogenesis of idiopathic Parkinson's disease

A Critical LRRK at the Synapse? The Neurobiological Function and Pathophysiological Dysfunction of LRRK2

Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice

G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

Maternal gastrointestinal nematode infection alters hippocampal neuroimmunity, promotes synaptic plasticity, and improves resistance to direct infection in offspring

Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice

The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation

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