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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

Neuron (Cambridge, Mass.), 2014-06, Vol.82 (6), p.1271-1288

2014

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Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

Neuron (Cambridge, Mass.), 2016-06, Vol.90 (5), p.941-947

2016

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Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Neuron (Cambridge, Mass.), 2016-11, Vol.92 (4), p.796-812

2016

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Emerging antisense oligonucleotide and viral therapies for amyotrophic lateral sclerosis

Current opinion in neurology, 2018-10, Vol.31 (5), p.648-654

2018

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

Proceedings of the National Academy of Sciences - PNAS, 2009-11, Vol.106 (44), p.18809-18814

2009

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Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

Proceedings of the National Academy of Sciences - PNAS, 2013-08, Vol.110 (33), p.E3138-E3147

2013

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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

Proceedings of the National Academy of Sciences - PNAS, 2013-12, Vol.110 (51), p.E4968-E4977

2013

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Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties

EMBO reports, 2021-12, Vol.22 (12), p.e53632-n/a

2021

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Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes

Annals of neurology, 2015-01, Vol.77 (1), p.100-113

2015

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Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation

Human molecular genetics, 2016-05, Vol.25 (9), p.1803-1813

2016

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Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

Human molecular genetics, 2013-10, Vol.22 (20), p.4127-4135

2013

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Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice

PloS one, 2023-11, Vol.18 (11), p.e0294731-e0294731

2023

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Delayed Diagnosis in Duchenne Muscular Dystrophy: Data from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)

The Journal of pediatrics, 2009-09, Vol.155 (3), p.380-385

2009

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CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

Scientific reports, 2020-03, Vol.10 (1), p.4921-4921, Article 4921

2020

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Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities

Muscle & nerve, 2020-08, Vol.62 (2), p.182-186

2020

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Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD

Nature communications, 2022-05, Vol.13 (1), p.2799-2799, Article 2799

2022

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Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

Proceedings of the National Academy of Sciences - PNAS, 2008-03, Vol.105 (10), p.4022-4027

2008

Volltextzugriff (PDF)

Unraveling the mechanisms involved in motor neuron degeneration in ALS

Annual review of neuroscience, 2004-01, Vol.27 (1), p.723-749

2004

Volltextzugriff (PDF)

Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo

Frontiers in molecular neuroscience, 2023-12, Vol.16, p.1320182-1320182

2023

Volltextzugriff (PDF)

SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy

JAMA neurology, 2013-02, Vol.70 (2), p.201

2013

Volltextzugriff (PDF)

Differential diagnosis of myotonic disorders

Muscle & nerve, 2008-03, Vol.37 (3), p.293-299

Miller, Timothy M.

2008

Volltextzugriff (PDF)

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

Neuron (Cambridge, Mass.), 2017-06, Vol.94 (6), p.1056-1070

2017

Volltextzugriff (PDF)

Muscle cramps

Muscle & nerve, 2005-10, Vol.32 (4), p.431-442

2005

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Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

eLife, 2020-10, Vol.9

2020

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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

Emerging antisense oligonucleotide and viral therapies for amyotrophic lateral sclerosis

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes

Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice

Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice

Delayed Diagnosis in Duchenne Muscular Dystrophy: Data from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet)

CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

Amyotrophic lateral sclerosis care and research in the United States during the COVID‐19 pandemic: Challenges and opportunities

Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria

Unraveling the mechanisms involved in motor neuron degeneration in ALS

Evaluating the efficacy of purchased antisense oligonucleotides to reduce mouse and human tau in vivo

SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy

Differential diagnosis of myotonic disorders

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

Muscle cramps

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

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