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Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Nature biotechnology, 2019-06, Vol.37 (6), p.626-631

2019

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A manganese catalyst for highly reactive yet chemoselective intramolecular C(sp(3))-H amination

Nature chemistry, 2015-12, Vol.7 (12), p.987-994

2015

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Targeting fidelity of adenine and cytosine base editors in mouse embryos

Nature communications, 2018-11, Vol.9 (1), p.4804-6, Article 4804

2018

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Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

PLoS pathogens, 2016-10, Vol.12 (10), p.e1005924

2016

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Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Frontiers in immunology, 2020-03, Vol.11, p.406

2020

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Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists

International journal of molecular sciences, 2024-09, Vol.25 (18), p.10031

2024

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Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitization

Frontiers in immunology, 2024-07, Vol.15, p.1421758

2024

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Advancing Adjuvants for Mycobacterium tuberculosis Therapeutics

Frontiers in immunology, 2021-10, Vol.12, p.740117-740117

2021

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Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists

Frontiers in immunology, 2019-02, Vol.10, p.338-338

2019

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Phage-assisted continuous and non-continuous evolution

Nature protocols, 2020-12, Vol.15 (12), p.4101-4127

2020

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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Nature (London), 2018-04, Vol.556 (7699), p.57-63

2018

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Vaccination with Mincle agonist UM-1098 and mycobacterial antigens induces protective Th1 and Th17 responses

npj vaccines, 2024-06, Vol.9 (1), p.100-15

2024

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Continuous evolution of SpCas9 variants compatible with non-G PAMs

Nature biotechnology, 2020-04, Vol.38 (4), p.471-481

2020

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A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice

npj vaccines, 2023-07, Vol.8 (1), p.97-14, Article 97

2023

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Next-generation biological vector platforms for in vivo delivery of genome editing agents

Current opinion in biotechnology, 2024-02, Vol.85, p.103040-103040, Article 103040

2024

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Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages

Vaccines (Basel), 2024-01, Vol.12 (2), p.115

2024

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A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models

npj vaccines, 2023-07, Vol.8 (1), p.107-17, Article 107

2023

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High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs

Nature biotechnology, 2023-01, Vol.41 (1), p.96-107

2023

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Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity

Journal of controlled release, 2019-12, Vol.315, p.186-196

2019

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Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis

Journal of medicinal chemistry, 2020-01, Vol.63 (1), p.309-320

2020

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CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection

Frontiers in immunology, 2016-12, Vol.7, p.659-659

2016

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Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication

The Journal of immunology (1950), 2016-03, Vol.196 (6), p.2711-2722

2016

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Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

Nature communications, 2015-10, Vol.6 (1), p.8608-8608, Article 8608

2015

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6,6′-Aryl trehalose analogs as potential Mincle ligands

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (14), p.115564-115564, Article 115564

2020

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Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

A manganese catalyst for highly reactive yet chemoselective intramolecular C(sp(3))-H amination

Targeting fidelity of adenine and cytosine base editors in mouse embryos

Follicular Regulatory CD8 T Cells Impair the Germinal Center Response in SIV and Ex Vivo HIV Infection

Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists

Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitization

Advancing Adjuvants for Mycobacterium tuberculosis Therapeutics

Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists

Phage-assisted continuous and non-continuous evolution

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

Vaccination with Mincle agonist UM-1098 and mycobacterial antigens induces protective Th1 and Th17 responses

Continuous evolution of SpCas9 variants compatible with non-G PAMs

A lipidated TLR7/8 adjuvant enhances the efficacy of a vaccine against fentanyl in mice

Next-generation biological vector platforms for in vivo delivery of genome editing agents

Adjuvanted Vaccine Induces Functional Antibodies against Pseudomonas aeruginosa Filamentous Bacteriophages

A TLR7/8 agonist increases efficacy of anti-fentanyl vaccines in rodent and porcine models

High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs

Co-encapsulation of synthetic lipidated TLR4 and TLR7/8 agonists in the liposomal bilayer results in a rapid, synergistic enhancement of vaccine-mediated humoral immunity

Aryl Trehalose Derivatives as Vaccine Adjuvants for Mycobacterium tuberculosis

CD4 T Follicular Helper and Regulatory Cell Dynamics and Function in HIV Infection

Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication

Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection

6,6′-Aryl trehalose analogs as potential Mincle ligands

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