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Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling

Circulation research, 2017-07, Vol.121 (2), p.137-148

2017

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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death

The Journal of clinical investigation, 2022-09, Vol.132 (18), p.1-16

2022

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Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

Redox biology, 2021-11, Vol.47, p.102166, Article 102166

2021

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Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

JCI insight, 2019-10, Vol.4 (19)

2019

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CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling

JCI insight, 2023-03, Vol.8 (5)

2023

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FoxO4 controls sGCβ transcription in vascular smooth muscle

American journal of physiology. Heart and circulatory physiology, 2022-03, Vol.322 (3), p.H417-H426

2022

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Identification and functional characterization of a novel arginine/ornithine transporter, a member of a cationic amino acid transporter subfamily in the Trypanosoma cruzi genome

Parasites & vectors, 2015-06, Vol.8 (1), p.346-346, Article 346

2015

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Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor–forkhead box subclass O transcription factor signalling axis

British journal of pharmacology, 2022-06, Vol.179 (11), p.2490-2504

2022

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Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression

Molecular pharmacology, 2019-06, Vol.95 (6), p.629-637

2019

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Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction

Arteriosclerosis, thrombosis, and vascular biology, 2014-12, Vol.34 (12), p.2594-2600

2014

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Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT 1 receptor-forkhead box subclass O transcription factor signalling axis

British journal of pharmacology, 2022-06, Vol.179 (11), p.2490-2504

2022

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Targeting Pulmonary Endothelial Hemoglobin a Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

American journal of respiratory cell and molecular biology, 2017-12, Vol.57 (6), p.733-744

2017

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Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability

The Journal of biological chemistry, 2015-07, Vol.290 (27), p.16861-16872

2015

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Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

American journal of respiratory cell and molecular biology, 2017-12, Vol.57 (6), p.733-744

2017

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Preclinical Development and Screening of a Quinone-Nitroalkene Molecule for Sickle Cell Anemia

Blood, 2022-11, Vol.140 (Supplement 1), p.957-958

2022

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Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1R - FoxO transcription factor signaling axis

British journal of pharmacology, 2021-06, Vol.179 (11), p.2490-2504

2021

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Abstract P146: Cytochrome B5 Reductase (CYB5R3) Function in Smooth Muscle Cells and Blood Pressure Regulation

Hypertension (Dallas, Tex. 1979), 2018-09, Vol.72 (Suppl_1)

2018

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Abstract 503: Smooth Muscle Cell Cytochrome B5 reductase < CYB5R3 > expression modulates vascular tone

Arteriosclerosis, thrombosis, and vascular biology, 2018-05, Vol.38 (Suppl_1)

2018

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Abstract 575: Loss of Function Variant in CYB5R3 Associates With Exacerbated Cardiac Hypertrophy in Mice

Circulation research, 2019-08, Vol.125 (Suppl_1)

2019

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Abstract 103: Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function

Circulation research, 2018-08, Vol.123 (Suppl_1)

2018

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Abstract 378: Cytochrome b5 Reductase 3 Regulates Vascular Smooth Muscle Phenotypic Switching

Arteriosclerosis, thrombosis, and vascular biology, 2016-05, Vol.36 (suppl_1)

2016

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Abstract 14: Identification of a Major Role for Cytochrome B5 Reductase 3 in Cardiomyocyte Metabolism and Function

Circulation research, 2017-07, Vol.121 (suppl_1)

2017

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Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 Were Identified by Structure Guided Chemical Modifications of Propylthiouracil

Free radical biology & medicine, 2014-11, Vol.76, p.S89-S90

2014

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206 - Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 Were Identified by Structure Guided Chemical Modifications of Propylthiouracil

Free radical biology & medicine, 2014-11, Vol.76, p.S89-S90

2014

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Application of the Aviation Black Box Principle in Pediatric Cardiac Surgery: Tracking All Failures in the Pediatric Cardiac Operating Room

Journal of the American College of Surgeons, 2015-02, Vol.220 (2), p.149-155.e3

2015

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Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling

Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death

Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation

Loss of smooth muscle CYB5R3 amplifies angiotensin-II induced hypertension by increasing sGC heme oxidation

CYB5R3 in type II alveolar epithelial cells protects against lung fibrosis by suppressing TGF-β1 signaling

FoxO4 controls sGCβ transcription in vascular smooth muscle

Identification and functional characterization of a novel arginine/ornithine transporter, a member of a cationic amino acid transporter subfamily in the Trypanosoma cruzi genome

Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT1 receptor–forkhead box subclass O transcription factor signalling axis

Antagonism of Forkhead Box Subclass O Transcription Factors Elicits Loss of Soluble Guanylyl Cyclase Expression

Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction

Angiotensin II augments renal vascular smooth muscle soluble GC expression via an AT 1 receptor-forkhead box subclass O transcription factor signalling axis

Targeting Pulmonary Endothelial Hemoglobin a Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Structure Guided Chemical Modifications of Propylthiouracil Reveal Novel Small Molecule Inhibitors of Cytochrome b5 Reductase 3 That Increase Nitric Oxide Bioavailability

Targeting Pulmonary Endothelial Hemoglobin α Improves Nitric Oxide Signaling and Reverses Pulmonary Artery Endothelial Dysfunction

Preclinical Development and Screening of a Quinone-Nitroalkene Molecule for Sickle Cell Anemia

Angiotensin II augments renal vascular smooth muscle sGC expression via an AT1R - FoxO transcription factor signaling axis

Abstract P146: Cytochrome B5 Reductase (CYB5R3) Function in Smooth Muscle Cells and Blood Pressure Regulation

Abstract 503: Smooth Muscle Cell Cytochrome B5 reductase < CYB5R3 > expression modulates vascular tone

Abstract 575: Loss of Function Variant in CYB5R3 Associates With Exacerbated Cardiac Hypertrophy in Mice

Abstract 103: Cytochrome b5 Reductase 3 Regulates Myoglobin Redox State and Controls Cardiac Function

Abstract 378: Cytochrome b5 Reductase 3 Regulates Vascular Smooth Muscle Phenotypic Switching

Abstract 14: Identification of a Major Role for Cytochrome B5 Reductase 3 in Cardiomyocyte Metabolism and Function

Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 Were Identified by Structure Guided Chemical Modifications of Propylthiouracil

206 - Novel Small Molecule Inhibitors of Cytochrome B5 Reductase 3 Were Identified by Structure Guided Chemical Modifications of Propylthiouracil

Application of the Aviation Black Box Principle in Pediatric Cardiac Surgery: Tracking All Failures in the Pediatric Cardiac Operating Room

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