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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Annual review of pharmacology and toxicology, 2021-01, Vol.61 (1), p.779-803

2021

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Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

Circulation research, 2011-05, Vol.108 (11), p.1392-1412

2011

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Aging cell, 2016-10, Vol.15 (5), p.973-977

2016

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Impact of Aortic Valve Calcification, as Measured by MDCT, on Survival in Patients With Aortic Stenosis

Journal of the American College of Cardiology, 2014-09, Vol.64 (12), p.1202-1213

2014

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Cell metabolism, 2018-05, Vol.27 (5), p.1081-1095.e10

2018

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Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Diabetes (New York, N.Y.), 2016-06, Vol.65 (6), p.1606-1615

2016

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Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

Journal of the American College of Cardiology, 2008-09, Vol.52 (10), p.843-850

2008

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Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Cell metabolism, 2016-06, Vol.23 (6), p.1207-1215

2016

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Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis

JACC. Cardiovascular imaging, 2019-02, Vol.12 (2), p.236-248

2019

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Influences of Sex and Estrogen in Arterial and Valvular Calcification

Frontiers in endocrinology (Lausanne), 2019-09, Vol.10, p.622-622

2019

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Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure

Circulation (New York, N.Y.), 2014-04, Vol.129 (17), p.1742-1750

2014

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Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight

European heart journal, 2016-02, Vol.37 (8), p.693-699

2016

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Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

The Journal of biological chemistry, 2015-07, Vol.290 (29), p.17946-17955

2015

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Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Cells (Basel, Switzerland), 2023-05, Vol.12 (9), p.1296

2023

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Calcific aortic valve stenosis in old hypercholesterolemic mice

Circulation (New York, N.Y.), 2006-11, Vol.114 (19), p.2065-2069

2006

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The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement

The journals of gerontology. Series A, Biological sciences and medical sciences, 2017-07, Vol.72 (7), p.917-921

2017

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Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice

Journal of cerebral blood flow and metabolism, 2010-01, Vol.30 (1), p.56-69

2010

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Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice

Frontiers in physiology, 2021-10, Vol.12, p.753501-753501

2021

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High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Epigenetics, 2017-01, Vol.12 (1), p.55-69

2017

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Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease

Circulation. Cardiovascular genetics, 2015-06, Vol.8 (3), p.516-528

2015

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Critical Role for Copper/Zinc-Superoxide Dismutase in Preventing Spontaneous Intracerebral Hemorrhage During Acute and Chronic Hypertension in Mice

Stroke (1970), 2010-04, Vol.41 (4), p.790-797

2010

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Nature (London), 2016-02, Vol.530 (7589), p.184-189

2016

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Respiratory System Determinants of Peripheral Fatigue and Endurance Performance

Medicine and science in sports and exercise, 2008-03, Vol.40 (3), p.457-461

2008

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Protective effect of extracellular superoxide dismutase on endothelial function during aging

American journal of physiology. Heart and circulatory physiology, 2009-06, Vol.296 (6), p.H1920-H1925

2009

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Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Calcific Aortic Valve Stenosis: Methods, Models, and Mechanisms

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

Impact of Aortic Valve Calcification, as Measured by MDCT, on Survival in Patients With Aortic Stenosis

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue

Dysregulation of Antioxidant Mechanisms Contributes to Increased Oxidative Stress in Calcific Aortic Valvular Stenosis in Humans

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Network Tomography for Understanding Phenotypic Presentations in Aortic Stenosis

Influences of Sex and Estrogen in Arterial and Valvular Calcification

Microtubule-Mediated Defects in Junctophilin-2 Trafficking Contribute to Myocyte Transverse-Tubule Remodeling and Ca2+ Handling Dysfunction in Heart Failure

Sex-related differences in calcific aortic stenosis: correlating clinical and echocardiographic characteristics and computed tomography aortic valve calcium score to excised aortic valve weight

Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes

Senescent Cells: A Therapeutic Target in Cardiovascular Diseases

Calcific aortic valve stenosis in old hypercholesterolemic mice

The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement

Spontaneous intracerebral hemorrhage during acute and chronic hypertension in mice

Sirtuin 6 Protects Against Oxidative Stress and Vascular Dysfunction in Mice

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Nonbiased Molecular Screening Identifies Novel Molecular Regulators of Fibrogenic and Proliferative Signaling in Myxomatous Mitral Valve Disease

Critical Role for Copper/Zinc-Superoxide Dismutase in Preventing Spontaneous Intracerebral Hemorrhage During Acute and Chronic Hypertension in Mice

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

Respiratory System Determinants of Peripheral Fatigue and Endurance Performance

Protective effect of extracellular superoxide dismutase on endothelial function during aging

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