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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Nature communications, 2024-05, Vol.15 (1), p.4054-4054

2024

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Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

Structure (London), 2013-06, Vol.21 (6), p.1030-1041

2013

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Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

Structure (London), 2013-01, Vol.21 (1), p.42-53

2013

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Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

Structure (London), 2017-06, Vol.25 (6), p.890-900.e5

2017

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Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Nature communications, 2020-10, Vol.11 (1), p.4931-14, Article 4931

2020

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Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

eLife, 2013-08, Vol.2, p.e00828

2013

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Structural basis for the transcriptional regulation of membrane lipid homeostasis

Nature structural & molecular biology, 2010-08, Vol.17 (8), p.971

2010

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Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family

The Journal of biological chemistry, 2016-03, Vol.291 (12), p.6292-6303

2016

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Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

The Journal of biological chemistry, 2009-05, Vol.284 (19), p.13174-13184

2009

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How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

The EMBO journal, 2009-07, Vol.28 (13), p.1953-1964

2009

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Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways

PloS one, 2010-12, Vol.5 (12), p.e15805-e15805

2010

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Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases

Structure (London), 2008-07, Vol.16 (7), p.1036-1046

2008

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Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Structure (London), 2023-12, Vol.31 (12), p.1545-1555.e9

2023

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Mechanism for the activation of the anaplastic lymphoma kinase receptor

Nature (London), 2021-12, Vol.600 (7887), p.153-157

2021

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Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Proceedings of the National Academy of Sciences - PNAS, 2023-03, Vol.120 (10), p.e2217804120-e2217804120

2023

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Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102195-102195, Article 102195

2022

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Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

Molecular cell, 2009-10, Vol.36 (1), p.39-50

2009

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The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)

The Journal of biological chemistry, 2020-05, Vol.295 (22), p.7635-7652

2020

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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Nucleic acids research, 2024-02, Vol.52 (4), p.1661

2024

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Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli

Journal of medicinal chemistry, 2006-01, Vol.49 (1), p.159-171

2006

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Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5

Journal of the American Chemical Society, 2021-11, Vol.143 (44), p.18467-18480

2021

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Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin

The Journal of biological chemistry, 2017-11, Vol.292 (44), p.18281-18289

2017

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Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase

The Journal of biological chemistry, 2009-03, Vol.284 (11), p.7246-7254

2009

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

Proceedings of the National Academy of Sciences - PNAS, 2019-08, Vol.116 (35), p.17280-17289

2019

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Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR

Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism

Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes

Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Structural basis for the transcriptional regulation of membrane lipid homeostasis

Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family

Crystal Structures of YkuI and Its Complex with Second Messenger Cyclic Di-GMP Suggest Catalytic Mechanism of Phosphodiester Bond Cleavage by EAL Domains

How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways

Analysis of the Staphylococcus aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases

Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand

Mechanism for the activation of the anaplastic lymphoma kinase receptor

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Biochemical characterization of the first step in sulfonolipid biosynthesis in Alistipes finegoldii

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)

Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Structure−Activity Relationships at the 5-Position of Thiolactomycin: An Intact (5R)-Isoprene Unit Is Required for Activity against the Condensing Enzymes from Mycobacterium tuberculosis and Escherichia coli

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5

Structural and functional insights into the interaction between the Cas family scaffolding protein p130Cas and the focal adhesion-associated protein paxillin

Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase

Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site

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