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ESKAPEing the labyrinth of antibacterial discovery

Nature reviews. Drug discovery, 2015-08, Vol.14 (8), p.529-542

2015

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Rational design of a new antibiotic class for drug-resistant infections

Nature (London), 2021-09, Vol.597 (7878), p.698-702

2021

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Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2015-03, Vol.59 (3), p.1680-1689

2015

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Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam

Frontiers in microbiology, 2021-07, Vol.12, p.709974-709974

2021

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Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

Journal of bacteriology, 2015-05, Vol.197 (10), p.1726-1734

2015

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Small-Molecule Inhibitors of Gram-Negative Lipoprotein Trafficking Discovered by Phenotypic Screening

Journal of bacteriology, 2015-03, Vol.197 (6), p.1075-1082

2015

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LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens

mBio, 2014-09, Vol.5 (5), p.e01551

2014

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Regulation of Staphylococcus aureus MntC expression and its role in response to oxidative stress

PloS one, 2013-10, Vol.8 (10), p.e77874-e77874

2013

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Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation

Journal of medicinal chemistry, 2012-01, Vol.55 (2), p.852-870

2012

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Development of a multicomponent Staphylococcus aureus vaccine designed to counter multiple bacterial virulence factors

Human vaccines & immunotherapeutics, 2012-11, Vol.8 (11), p.1585-1594

2012

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In Vitro Activity of Sulbactam-Durlobactam against Global Isolates of Acinetobacter baumannii-calcoaceticus Complex Collected from 2016 to 2021

Antimicrobial agents and chemotherapy, 2022-09, Vol.66 (9), p.e0078122-e0078122

2022

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Characterization of Acinetobacter baumannii-calcoaceticus complex isolates and microbiological outcome for patients treated with sulbactam-durlobactam in a phase 3 trial (ATTACK)

Antimicrobial agents and chemotherapy, 2024-05, Vol.68 (5), p.e0169823

2024

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In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii- calcoaceticus Complex Isolates Collected Globally in 2016 and 2017

Antimicrobial agents and chemotherapy, 2020-03, Vol.64 (4)

2020

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Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species

Clinical infectious diseases, 2023-05, Vol.76 (Suppl 2), p.S194-S201

2023

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I n vitro pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex

Antimicrobial agents and chemotherapy, 2024-01, Vol.68 (1), p.e0031223-e0031223

2024

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Zoliflodacin: An Oral Spiropyrimidinetrione Antibiotic for the Treatment of Neisseria gonorrheae , Including Multi-Drug-Resistant Isolates

ACS infectious diseases, 2020-06, Vol.6 (6), p.1332-1345

2020

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Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

Antimicrobial Agents and Chemotherapy, 2008-08, Vol.52 (8), p.2806-2812

2008

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In vitro antibacterial activity of sulbactam-durlobactam in combination with other antimicrobial agents against Acinetobacter baumannii-calcoaceticus complex

Diagnostic microbiology and infectious disease, 2024-07, Vol.109 (3), p.116344-116344, Article 116344

2024

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Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors

Journal of antibiotics, 2015-06, Vol.68 (6), p.361-367

2015

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Sulbactam-durlobactam susceptibility test method development and quality control ranges for MIC and disk diffusion tests

Journal of clinical microbiology, 2024-01, Vol.62 (1), p.e0122823-e0122823

2024

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Role of the Klebsiella pneumoniae TolC porin in antibiotic efflux

Research in microbiology, 2019-03, Vol.170 (2), p.112-116

2019

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Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2018-02, Vol.62 (2)

2018

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Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of Acinetobacter baumannii

Antimicrobial agents and chemotherapy, 2023-11, Vol.67 (11), p.e0066523-e0066523

2023

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Antibacterial Drug Discovery: Some Assembly Required

ACS infectious diseases, 2018-05, Vol.4 (5), p.686-695

2018

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ESKAPEing the labyrinth of antibacterial discovery

Rational design of a new antibiotic class for drug-resistant infections

Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii

Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam

Novel Antibacterial Targets and Compounds Revealed by a High-Throughput Cell Wall Reporter Assay

Small-Molecule Inhibitors of Gram-Negative Lipoprotein Trafficking Discovered by Phenotypic Screening

LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens

Regulation of Staphylococcus aureus MntC expression and its role in response to oxidative stress

Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane β-Lactamase Inhibitor To Augment β-Lactam Action

Structure Guided Development of Novel Thymidine Mimetics Targeting Pseudomonas aeruginosa Thymidylate Kinase: From Hit to Lead Generation

Development of a multicomponent Staphylococcus aureus vaccine designed to counter multiple bacterial virulence factors

In Vitro Activity of Sulbactam-Durlobactam against Global Isolates of Acinetobacter baumannii-calcoaceticus Complex Collected from 2016 to 2021

Characterization of Acinetobacter baumannii-calcoaceticus complex isolates and microbiological outcome for patients treated with sulbactam-durlobactam in a phase 3 trial (ATTACK)

In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii- calcoaceticus Complex Isolates Collected Globally in 2016 and 2017

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species

I n vitro pharmacokinetics/pharmacodynamics of the β-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex

Zoliflodacin: An Oral Spiropyrimidinetrione Antibiotic for the Treatment of Neisseria gonorrheae , Including Multi-Drug-Resistant Isolates

Discovery and Characterization of QPT-1, the Progenitor of a New Class of Bacterial Topoisomerase Inhibitors

In vitro antibacterial activity of sulbactam-durlobactam in combination with other antimicrobial agents against Acinetobacter baumannii-calcoaceticus complex

Discovery and characterization of a novel class of pyrazolopyrimidinedione tRNA synthesis inhibitors

Sulbactam-durlobactam susceptibility test method development and quality control ranges for MIC and disk diffusion tests

Role of the Klebsiella pneumoniae TolC porin in antibiotic efflux

Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel β-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii

Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of Acinetobacter baumannii

Antibacterial Drug Discovery: Some Assembly Required

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