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Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

Advanced drug delivery reviews, 2009-11, Vol.61 (14), p.1250-1275

2009

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Integrin targeted therapeutics

Theranostics, 2011-02, Vol.1 (1), p.154-188

2011

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In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

Journal of the American Chemical Society, 2013-08, Vol.135 (31), p.11623-11633

2013

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Preclinical evaluation of novel triphenylphosphonium salts with broad-spectrum activity

PloS one, 2010-10, Vol.5 (10), p.e13131

2010

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Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update

Current pharmaceutical design, 2011-02, Vol.17 (6), p.536

2011

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Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells

PloS one, 2013-01, Vol.8 (1), p.e54346

2013

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Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

Nature genetics, 2001-06, Vol.28 (2), p.155-159

2001

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465 Development of ex vivo 3D tumor models to aid in immuno-oncology drug discovery efforts

Journal for immunotherapy of cancer, 2023-11, Vol.11 (Suppl 1), p.A519-A519

2023

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Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

Science (American Association for the Advancement of Science), 2000-02, Vol.287 (5456), p.1253-1258

2000

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Aquatic flatworms use chemical cues from injured conspecifics to assess predation risk and to associate risk with novel cues

Animal behaviour, 2001-10, Vol.62 (4), p.761-766

2001

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A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers

Journal of medicinal chemistry, 2013-11, Vol.56 (22), p.9170-9179

2013

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Abstract 202: Perfused patient-derived tumor organoid models with autologous immune cells for preclinical drug development

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.202-202

2023

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Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis

The Journal of biological chemistry, 2002-12, Vol.277 (51), p.49531-49537

2002

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Abstract 2480: Discovery and mechanistic characterization of AV220, a novel small molecule targeting cancer cell metabolism

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2480-2480

2013

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The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma

FEBS letters, 2024-01, Vol.598 (2), p.252-265

2024

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Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

Scientific reports, 2019-08, Vol.9 (1), p.11153-13, Article 11153

2019

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Abstract 6018: The perfused 3DKUBE™ rare tumor assay models in vivo drug response

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6018-6018

2020

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Abstract 177: Ex vivo 3D culture of adenoid cystic carcinoma PDX models recapitulate disease biomarkers and predict drug response

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.177-177

2022

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Abstract 3086: Organoids standardized to a clinically validated drug response assay for truly predictive in vitro drug response profiling

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.3086-3086

2022

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Abstract 1923: Paired isolation and expansion of CSC and CTC from primary small cell lung cancer patient tissue and blood using the 3DKUBE bioreactor platform

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.1923-1923

2017

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Abstract 2531: Marker free isolation and expansion of cancer stem cells from small cell lung cancer

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.2531-2531

2016

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Abstract 1121: Profiling patient-specific glioblastoma drug response in vitro using complex 3D microtumors

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1121-1121

2018

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Abstract 2275: Preclinical testing of therapeutic biologics using patient-derived 3D spheroids

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.2275-2275

2023

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Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126

Oncotarget, 2017-08, Vol.8 (32), p.52193-52210

2017

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Abstract 5673: Complex, patient-derived, multi-cell type, 3D models of breast cancer for personalized prediction of therapeutic response

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.5673-5673

2018

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Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism

Integrin targeted therapeutics

In Vivo Activation of the p53 Tumor Suppressor Pathway by an Engineered Cyclotide

Preclinical evaluation of novel triphenylphosphonium salts with broad-spectrum activity

Small-molecule inhibitors of p53-MDM2 interaction: the 2006-2010 update

Mechanistic evaluation of a novel small molecule targeting mitochondria in pancreatic cancer cells

Telomere dysfunction and evolution of intestinal carcinoma in mice and humans

465 Development of ex vivo 3D tumor models to aid in immuno-oncology drug discovery efforts

Inhibition of Experimental Liver Cirrhosis in Mice by Telomerase Gene Delivery

Aquatic flatworms use chemical cues from injured conspecifics to assess predation risk and to associate risk with novel cues

A Selective Mitochondrial-Targeted Chlorambucil with Remarkable Cytotoxicity in Breast and Pancreatic Cancers

Abstract 202: Perfused patient-derived tumor organoid models with autologous immune cells for preclinical drug development

Ceramide Signaling in Fenretinide-induced Endothelial Cell Apoptosis

Abstract 2480: Discovery and mechanistic characterization of AV220, a novel small molecule targeting cancer cell metabolism

The mitotic checkpoint kinase BUB1 is a direct and actionable target of MYB in adenoid cystic carcinoma

Prospective Validation of an Ex Vivo, Patient-Derived 3D Spheroid Model for Response Predictions in Newly Diagnosed Ovarian Cancer

Abstract 6018: The perfused 3DKUBE™ rare tumor assay models in vivo drug response

Abstract 177: Ex vivo 3D culture of adenoid cystic carcinoma PDX models recapitulate disease biomarkers and predict drug response

Abstract 3086: Organoids standardized to a clinically validated drug response assay for truly predictive in vitro drug response profiling

Abstract 1923: Paired isolation and expansion of CSC and CTC from primary small cell lung cancer patient tissue and blood using the 3DKUBE bioreactor platform

Abstract 2531: Marker free isolation and expansion of cancer stem cells from small cell lung cancer

Abstract 1121: Profiling patient-specific glioblastoma drug response in vitro using complex 3D microtumors

Abstract 2275: Preclinical testing of therapeutic biologics using patient-derived 3D spheroids

Association of high microvessel αvβ3 and low PTEN with poor outcome in stage 3 neuroblastoma: rationale for using first in class dual PI3K/BRD4 inhibitor, SF1126

Abstract 5673: Complex, patient-derived, multi-cell type, 3D models of breast cancer for personalized prediction of therapeutic response

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