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ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Nature communications, 2020-11, Vol.11 (1), p.5594-14, Article 5594

2020

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A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery

International journal of molecular sciences, 2022-06, Vol.23 (13), p.6883

2022

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Strain and Age Effects on Aqueous Humor Dynamics in the Mouse

Investigative ophthalmology & visual science, 2015-09, Vol.56 (10), p.5764-5776

2015

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Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

Investigative ophthalmology & visual science, 2019-05, Vol.60 (6), p.1967-1978

2019

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Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

Scientific reports, 2017-11, Vol.7 (1), p.14951-14, Article 14951

2017

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ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice

Investigative ophthalmology & visual science, 2021-05, Vol.62 (6), p.3-3

2021

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Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

Proceedings of the National Academy of Sciences - PNAS, 2021-04, Vol.118 (16), p.1

2021

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BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

Investigative ophthalmology & visual science, 2018-04, Vol.59 (5), p.2154-2166

2018

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Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

Scientific reports, 2018-01, Vol.8 (1), p.862-13, Article 862

2018

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CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Molecular neurodegeneration, 2020-08, Vol.15 (1), p.48-20, Article 48

2020

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Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion

Investigative ophthalmology & visual science, 2011-02, Vol.52 (2), p.685-694

2011

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Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent Eyes

Investigative ophthalmology & visual science, 2010-04, Vol.51 (4), p.2067

2010

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Early-Onset Glaucoma in egl1 Mice Homozygous for Pitx2 Mutation

Biomedicines, 2022-02, Vol.10 (3), p.516

2022

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Secreted protein acidic and rich in cysteine (SPARC) knockout mice have greater outflow facility

PloS one, 2020-11, Vol.15 (11), p.e0241294-e0241294

2020

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Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Scientific reports, 2024-03, Vol.14 (1), p.6958-13, Article 6958

2024

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Toward an improved understanding of the physiology of aqueous humor flow

Investigative ophthalmology & visual science, 2014-01, Vol.55 (1), p.404-404

Millar, J Cameron

2014

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Existence of the canonical Wnt signaling pathway in the human trabecular meshwork

Investigative ophthalmology & visual science, 2012-10, Vol.53 (11), p.7043-7051

2012

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Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure

The Journal of clinical investigation, 2008-03, Vol.118 (3), p.1056-1064

2008

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Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure

Human molecular genetics, 2007-03, Vol.16 (6), p.609-617

2007

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Viral Vector-Induced Ocular Hypertension in Mice

Methods in molecular biology (Clifton, N.J.), 2023, Vol.2708, p.77

2023

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The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure

Investigative ophthalmology & visual science, 2018-03, Vol.59 (3), p.1454-1466

2018

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Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration

The American journal of pathology, 2017-04, Vol.187 (4), p.713-723

2017

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Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork

Investigative ophthalmology & visual science, 2016-11, Vol.57 (14), p.6058-6069

2016

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Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice

Experimental eye research, 2019-11, Vol.188, p.107763-107763, Article 107763

2019

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Knockout of tissue transglutaminase ameliorates TGFβ2-induced ocular hypertension: A novel therapeutic target for glaucoma?

Experimental eye research, 2018-06, Vol.171, p.106-110

2018

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ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

A Novel Mouse Model of TGFβ2-Induced Ocular Hypertension Using Lentiviral Gene Delivery

Strain and Age Effects on Aqueous Humor Dynamics in the Mouse

Glucocorticoid Receptor Transactivation Is Required for Glucocorticoid-Induced Ocular Hypertension and Glaucoma

Increased synthesis and deposition of extracellular matrix proteins leads to endoplasmic reticulum stress in the trabecular meshwork

ID1 and ID3 are Negative Regulators of TGFβ2-Induced Ocular Hypertension and Compromised Aqueous Humor Outflow Facility in Mice

Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork

Glucocorticoid receptor GRβ regulates glucocorticoid-induced ocular hypertension in mice

CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

Assessment of aqueous humor dynamics in the mouse by a novel method of constant-flow infusion

Adenoviral Gene Transfer of Active Human Transforming Growth Factor-β2 Elevates Intraocular Pressure and Reduces Outflow Facility in Rodent Eyes

Early-Onset Glaucoma in egl1 Mice Homozygous for Pitx2 Mutation

Secreted protein acidic and rich in cysteine (SPARC) knockout mice have greater outflow facility

Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Toward an improved understanding of the physiology of aqueous humor flow

Existence of the canonical Wnt signaling pathway in the human trabecular meshwork

Increased expression of the WNT antagonist sFRP-1 in glaucoma elevates intraocular pressure

Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure

Viral Vector-Induced Ocular Hypertension in Mice

The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure

Dexamethasone-Induced Ocular Hypertension in Mice: Effects of Myocilin and Route of Administration

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork

Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice

Knockout of tissue transglutaminase ameliorates TGFβ2-induced ocular hypertension: A novel therapeutic target for glaucoma?

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