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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors

Current medicinal chemistry, 2017-08, Vol.24 (28), p.3025

2017

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Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu7 Receptor Modulation Activity and Antipsychotic-Like Properties

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1981

2023

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Mapping Adverse Drug Reactions in Chemical Space

Journal of medicinal chemistry, 2009-05, Vol.52 (9), p.3103-3107

2009

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Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock

European journal of medicinal chemistry, 2021-03, Vol.213, p.113057, Article 113057

2021

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Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

Journal of Chemical Information and Modeling, 2009-02, Vol.49 (2), p.308-317

2009

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How to design potent and selective DYRK1B inhibitors? Molecular modeling study

Journal of molecular modeling, 2019-02, Vol.25 (2), p.41-12, Article 41

2019

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5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors

Bioorganic & medicinal chemistry letters, 2019-02, Vol.29 (4), p.607-613

2019

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Algorithm for rapid reconstruction of protein backbone from alpha carbon coordinates

Journal of computational chemistry, 1997-01, Vol.18 (1), p.80-85

1997

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Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu 7 Receptor Modulation Activity and Antipsychotic-Like Properties

International journal of molecular sciences, 2023-01, Vol.24 (3)

2023

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Abstract C194: Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in cancer

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C194-C194

2015

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Abstract A49: Repression of tumor survival pathways by novel, selective inhibitors of MNK1 and MNK2 kinases

Cancer research (Chicago, Ill.), 2013-10, Vol.73 (19_Supplement), p.A49-A49

2013

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Abstract 2160: Development of selective MELK kinase inhibitors for cancer treatments

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.2160-2160

2013

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Abstract 755: Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in glioblastoma and colorectal cancer

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.755-755

2014

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Abstract 3845: Antitumor activity of SEL120: An orally available dual inhibitors of Haspin/CDK9, for standalone and combination therapy with AuroraB inhibitors in solid tumors and hematopoietic malignancies

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.3845-3845

2012

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Abstract 3245: Identification of potent, dual PIM/FLT3 kinase inhibitors for AML treatment

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.3245-3245

2013

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“Virtual Fragment Linking”: An Approach To Identify Potent Binders from Low Affinity Fragment Hits

Journal of medicinal chemistry, 2008-04, Vol.51 (8), p.2481-2491

2008

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Abstract 696: Development of selective CDK8 inhibitors for colorectal cancer and mantle cell lymphoma treatment

Cancer research (Chicago, Ill.), 2013-04, Vol.73 (8_Supplement), p.696-696

2013

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Abstract A243: Novel Pim kinase inhibitors for treatment of hematological malignancies and solid tumors

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.A243-A243

2011

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Abstract B242: Antitumor activity of SEL120: An orally available small-molecule inhibitor of Haspin kinase for standalone and combination therapy with AuroraB inhibitors in colorectal cancer

Molecular cancer therapeutics, 2011-11, Vol.10 (11_Supplement), p.B242-B242

2011

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Abstract 2826: Preclinical development of a Pim kinase inhibitor for cancer treatment

Cancer research (Chicago, Ill.), 2012-04, Vol.72 (8_Supplement), p.2826-2826

2012

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Common Structural Cliques: a tool for protein structure and function analysis

Protein engineering, 2003-08, Vol.16 (8), p.543-552

2003

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Insertion of peptide chains into lipid membranes: An off-lattice Monte Carlo dynamics model

Proteins, structure, function, and bioinformatics, 1993-01, Vol.15 (1), p.10-25

1993

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Application of an artificial neural network to predict specific class I MHC binding peptide sequences

Nature biotechnology, 1998-08, Vol.16 (8), p.753-756

1998

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SPREAD-exploiting chemical features that cause differential activity behavior

Statistical analysis and data mining, 2009-08, Vol.2 (2), p.115-122

2009

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A reduced model of short range interactions in polypeptide chains

The Journal of chemical physics, 1995-09, Vol.103 (10), p.4312-4323

1995

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Mitogen-activated Protein Kinase (MAPK) Interacting Kinases 1 and 2 (MNK1 and MNK2) as Targets for Cancer Therapy: Recent Progress in the Development of MNK Inhibitors

Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu7 Receptor Modulation Activity and Antipsychotic-Like Properties

Mapping Adverse Drug Reactions in Chemical Space

Discovery of indazole-pyridinone derivatives as a novel class of potent and selective MNK1/2 kinase inhibitors that protecting against endotoxin-induced septic shock

Gaining Insight into Off-Target Mediated Effects of Drug Candidates with a Comprehensive Systems Chemical Biology Analysis

How to design potent and selective DYRK1B inhibitors? Molecular modeling study

5-Keto-3-cyano-2,4-diaminothiophenes as selective maternal embryonic leucine zipper kinase inhibitors

Algorithm for rapid reconstruction of protein backbone from alpha carbon coordinates

Design and Synthesis of New Quinazolin-4-one Derivatives with Negative mGlu 7 Receptor Modulation Activity and Antipsychotic-Like Properties

Abstract C194: Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in cancer

Abstract A49: Repression of tumor survival pathways by novel, selective inhibitors of MNK1 and MNK2 kinases

Abstract 2160: Development of selective MELK kinase inhibitors for cancer treatments

Abstract 755: Repression of tumor survival pathways by novel and selective inhibitors of MNK1 and MNK2 kinases in glioblastoma and colorectal cancer

Abstract 3845: Antitumor activity of SEL120: An orally available dual inhibitors of Haspin/CDK9, for standalone and combination therapy with AuroraB inhibitors in solid tumors and hematopoietic malignancies

Abstract 3245: Identification of potent, dual PIM/FLT3 kinase inhibitors for AML treatment

“Virtual Fragment Linking”: An Approach To Identify Potent Binders from Low Affinity Fragment Hits

Abstract 696: Development of selective CDK8 inhibitors for colorectal cancer and mantle cell lymphoma treatment

Abstract A243: Novel Pim kinase inhibitors for treatment of hematological malignancies and solid tumors

Abstract B242: Antitumor activity of SEL120: An orally available small-molecule inhibitor of Haspin kinase for standalone and combination therapy with AuroraB inhibitors in colorectal cancer

Abstract 2826: Preclinical development of a Pim kinase inhibitor for cancer treatment

Common Structural Cliques: a tool for protein structure and function analysis

Insertion of peptide chains into lipid membranes: An off-lattice Monte Carlo dynamics model

Application of an artificial neural network to predict specific class I MHC binding peptide sequences

SPREAD-exploiting chemical features that cause differential activity behavior

A reduced model of short range interactions in polypeptide chains

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