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An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

Journal of medicinal chemistry, 2011-01, Vol.54 (1), p.67-77

2011

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Practical synthetic routes to carbon-substituted nucleosides

Tetrahedron letters, 2011-11, Vol.52 (48), p.6415-6419

2011

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Structure−Activity Relationships of 1-Alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective Antagonists of the Neurokinin-2 Receptor

Journal of medicinal chemistry, 2002-11, Vol.45 (24), p.5365-5377

2002

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Optimization of 5‐Aryloxyimidazole Non‐Nucleoside Reverse Transcriptase Inhibitors

ChemMedChem, 2008-11, Vol.3 (11), p.1756-1762

2008

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Tandem [4 + 2]/[3 + 2] Cycloadditions of Nitroalkenes. 9. Synthesis of (−)-Rosmarinecine

Journal of the American Chemical Society, 1996-09, Vol.118 (35), p.8266-8277

1996

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Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

Journal of medicinal chemistry, 2009-02, Vol.52 (4), p.1219-1223

2009

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Non-benzimidazole containing inhibitors of respiratory syncytial virus

Bioorganic & medicinal chemistry letters, 2013-02, Vol.23 (3), p.827-833

2013

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Comparison of the Non-Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers

Chemical biology & drug design, 2011-05, Vol.77 (5), p.393-397

2011

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1-Amido-1-phenyl-3-piperidinylbutanes – CCR5 antagonists for the treatment of HIV: Part 2

Bioorganic & medicinal chemistry letters, 2009-03, Vol.19 (5), p.1499-1503

2009

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1-Amido-1-phenyl-3-piperidinylbutanes — CCR5 antagonists for the treatment of HIV. Part 1

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1075-1079

2009

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Synthesis and Biological Evaluation of Acyclic Phosphonic Acid Nucleoside Derivatives

Nucleosides, nucleotides & nucleic acids, 2013-09, Vol.32 (9), p.477-492

2013

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A General Strategy for the Synthesis of Cis-Substituted Pyrrolizidine Bases. The Synthesis of (-)-Rosmarinecine

Journal of organic chemistry, 1995-06, Vol.60 (12), p.3574-3575

1995

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An in situ oxidation strategy towards overcoming hERG affinity

Bioorganic & medicinal chemistry letters, 2010-11, Vol.20 (22), p.6400-6404

2010

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Discovery of a small molecule inhibitor through interference with the gp120–CD4 interaction

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5246-5249

2009

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Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: Structure–activity relationships of (thioalkyl)phenoxy benzylamines

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (19), p.5303-5306

2008

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Design and optimisation of potent gp120-CD4 inhibitors

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5250-5255

2009

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The design and discovery of novel amide CCR5 antagonists

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1084-1088

2009

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Designing rapid onset selective serotonin re-uptake inhibitors. 2: Structure–activity relationships of substituted (aryl)benzylamines

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4018-4021

2008

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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

MedChemComm, 2011-03, Vol.2 (3), p.185-189

2011

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Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 17. The Spiro Mode. Efficient and Highly Selective Synthesis of Azapropellanes

Journal of organic chemistry, 1998-03, Vol.63 (5), p.1604-1618

1998

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Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder

Bioorganic & medicinal chemistry, 2007, Vol.15 (1), p.142-159

2007

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Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1 S,4 S)-4-(3,4-dichlorophenyl)- N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1434-1439

2006

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Structure–activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption

Bioorganic & medicinal chemistry letters, 2005-09, Vol.15 (17), p.3957-3961

2005

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Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.905-910

2006

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Cytochrome P450 Metabolism and Inhibition: Analysis for Drug Discovery

Progress in Medicinal Chemistry, 2009, Vol.47, p.239-263

2009

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An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)

Practical synthetic routes to carbon-substituted nucleosides

Structure−Activity Relationships of 1-Alkyl-5-(3,4-dichlorophenyl)- 5-{2-[(3-substituted)-1-azetidinyl]ethyl}-2-piperidones. 1. Selective Antagonists of the Neurokinin-2 Receptor

Optimization of 5‐Aryloxyimidazole Non‐Nucleoside Reverse Transcriptase Inhibitors

Tandem [4 + 2]/[3 + 2] Cycloadditions of Nitroalkenes. 9. Synthesis of (−)-Rosmarinecine

Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays

Non-benzimidazole containing inhibitors of respiratory syncytial virus

Comparison of the Non-Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers

1-Amido-1-phenyl-3-piperidinylbutanes – CCR5 antagonists for the treatment of HIV: Part 2

1-Amido-1-phenyl-3-piperidinylbutanes — CCR5 antagonists for the treatment of HIV. Part 1

Synthesis and Biological Evaluation of Acyclic Phosphonic Acid Nucleoside Derivatives

A General Strategy for the Synthesis of Cis-Substituted Pyrrolizidine Bases. The Synthesis of (-)-Rosmarinecine

An in situ oxidation strategy towards overcoming hERG affinity

Discovery of a small molecule inhibitor through interference with the gp120–CD4 interaction

Designing rapid onset selective serotonin re-uptake inhibitors. Part 3: Site-directed metabolism as a strategy to avoid active circulating metabolites: Structure–activity relationships of (thioalkyl)phenoxy benzylamines

Design and optimisation of potent gp120-CD4 inhibitors

The design and discovery of novel amide CCR5 antagonists

Designing rapid onset selective serotonin re-uptake inhibitors. 2: Structure–activity relationships of substituted (aryl)benzylamines

The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection

Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 17. The Spiro Mode. Efficient and Highly Selective Synthesis of Azapropellanes

Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder

Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1 S,4 S)-4-(3,4-dichlorophenyl)- N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine

Structure–activity relationships of 1-alkyl-5-(3,4-dichlorophenyl)-5-{2-[3-(substituted)-1-azetidinyl]-ethyl}-2-piperidones. Part 2: Improving oral absorption

Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1

Cytochrome P450 Metabolism and Inhibition: Analysis for Drug Discovery

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