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A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups

PloS one, 2021-03, Vol.16 (3), p.e0246828

2021

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Matrix-Dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell-Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

The Journal of cell biology, 1998-11, Vol.143 (5), p.1385-1398

1998

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Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial

Women's health (London, England), 2018, Vol.14, p.1745506518788970-1745506518788970

2018

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Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

Science (American Association for the Advancement of Science), 1997-11, Vol.278 (5342), p.1464-1466

1997

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The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

The Journal of cell biology, 1997-11, Vol.139 (3), p.797-807

1997

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A role for Rac in Tiaml-induced membrane ruffling and invasion

Nature (London), 1995-05, Vol.375 (6529), p.338-340

1995

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Adenoviral vectors expressing siRNAs for discovery and validation of gene function

Genome research, 2003-10, Vol.13 (10), p.2325

2003

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Rac Affects Invasion of Human Renal Cell Carcinomas by Up-regulating Tissue Inhibitor of Metalloproteinases (TIMP)-1 and TIMP-2 Expression

The Journal of biological chemistry, 2001-11, Vol.276 (45), p.41889-41897

2001

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Regulated Membrane Localization of Tiam1, Mediated by the NH2-Terminal Pleckstrin Homology Domain, Is Required for Rac-Dependent Membrane Ruffling and C-Jun NH2-Terminal Kinase Activation

The Journal of cell biology, 1997-04, Vol.137 (2), p.387-398

1997

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Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain

The Journal of biological chemistry, 1997-11, Vol.272 (45), p.28447-28454

1997

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Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

Nature (London), 2002-06, Vol.417 (6891), p.867-871

2002

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A role for Rac in Tiam1-induced membrane ruffling and invasion

Nature (London), 1995-05, Vol.375 (6529), p.338-340

1995

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Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

Biochemical journal, 2006-07, Vol.397 (1), p.39-45

2006

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Arrayed adenoviral expression libraries for functional screening

Nature biotechnology, 2002-11, Vol.20 (11), p.1154-1157

2002

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One step further towards real high throughput functional genomics: Response from Frits Michiels, Helmuth van Es and Peter Tomme

Trends in biotechnology (Regular ed.), 2003-04, Vol.21 (4), p.147-148

2003

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One step further towards real high throughput functional genomics

Trends in biotechnology (Regular ed.), 2003-04, Vol.21 (4), p.147-148

2003

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Rho-like GTPases: their role in cell adhesion and invasion

Biochemical Society Symposia, 1999, Vol.65, p.125-146

1999

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Corrigendum: Arrayed adenoviral expression libraries for functional screening

Nature biotechnology, 2003-02, Vol.21 (2), p.199-199

2003

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International System for Education, Training and Qualification of Welding Personnel

Welding in the world, 2002-05, Vol.46 (5-6), p.35-37

2002

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Further sequence requirements for male germ cell-specific expression under the control of the 14 bp promoter element (β2UE1) of the Drosophila β2 tubulin gene

Nucleic acids research, 1991-08, Vol.19 (16), p.4515-4521

1991

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Inhibition of invasion of epithelial cells by Tiam(1)-Rac signaling

Science (American Association for the Advancement of Science), 1997-11, Vol.278 (5342), p.1464-1466

1997

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Identification of enriched sequences from a cDNA subtraction - hybridization procedure

Nucleic acids research, 1994-03, Vol.22 (5), p.878-879

1994

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Inhibition of Invasion of Epithelial Cells by Tiam 1-Rac Signaling

Science (American Association for the Advancement of Science), 1997-11, Vol.278 (5342), p.1464-1466

1997

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Netherlands: Inventive step or not, that is the question

Managing Intellectual Property, 2014-10

2014

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A survival of the fittest strategy for the selection of genotypes by which drug responders and non-responders can be predicted in small groups

Matrix-Dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell-Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase

Genotype scores predict drug efficacy in subtypes of female sexual interest/arousal disorder: A double-blind, randomized, placebo-controlled cross-over trial

Inhibition of invasion of epithelial cells by Tiam1-Rac signaling

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho

A role for Rac in Tiaml-induced membrane ruffling and invasion

Adenoviral vectors expressing siRNAs for discovery and validation of gene function

Rac Affects Invasion of Human Renal Cell Carcinomas by Up-regulating Tissue Inhibitor of Metalloproteinases (TIMP)-1 and TIMP-2 Expression

Regulated Membrane Localization of Tiam1, Mediated by the NH2-Terminal Pleckstrin Homology Domain, Is Required for Rac-Dependent Membrane Ruffling and C-Jun NH2-Terminal Kinase Activation

Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours

A role for Rac in Tiam1-induced membrane ruffling and invasion

Interaction between Tiam1 and the Arp2/3 complex links activation of Rac to actin polymerization

Arrayed adenoviral expression libraries for functional screening

One step further towards real high throughput functional genomics: Response from Frits Michiels, Helmuth van Es and Peter Tomme

One step further towards real high throughput functional genomics

Erratum: Corrigendum: Arrayed adenoviral expression libraries for functional screening

Rho-like GTPases: their role in cell adhesion and invasion

Corrigendum: Arrayed adenoviral expression libraries for functional screening

International System for Education, Training and Qualification of Welding Personnel

Further sequence requirements for male germ cell-specific expression under the control of the 14 bp promoter element (β2UE1) of the Drosophila β2 tubulin gene

Inhibition of invasion of epithelial cells by Tiam(1)-Rac signaling

Identification of enriched sequences from a cDNA subtraction - hybridization procedure

Inhibition of Invasion of Epithelial Cells by Tiam 1-Rac Signaling

Netherlands: Inventive step or not, that is the question

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