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High-Throughput Screening: today’s biochemical and cell-based approaches

Drug discovery today, 2020-10, Vol.25 (10), p.1807-1821

2020

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Screening for noise in gene expression identifies drug synergies

Science (American Association for the Advancement of Science), 2014-06, Vol.344 (6190), p.1392-1396

2014

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Nature reviews. Drug discovery, 2004-04, Vol.3 (4), p.301-317

2004

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Pharmacological brake-release of mRNA translation enhances cognitive memory

eLife, 2013-05, Vol.2, p.e00498-e00498

2013

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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit

PLoS neglected tropical diseases, 2011-07, Vol.5 (7), p.e1253

2011

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Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery

Current topics in medicinal chemistry, 2017-01, Vol.17 (1), p.4

2017

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Nature medicine, 2012-06, Vol.18 (6), p.956-960

2012

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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Proceedings of the National Academy of Sciences - PNAS, 2014-12, Vol.111 (52), p.18590-18595

2014

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Altered cofactor regulation with disease-associated p97/VCP mutations

Proceedings of the National Academy of Sciences - PNAS, 2015-04, Vol.112 (14), p.E1705-E1714

2015

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Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Chemistry & biology, 2014-09, Vol.21 (9), p.1102-1114

2014

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Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia

Haematologica (Roma), 2023-05, Vol.108 (5), p.1272

2023

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A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

ACS chemical biology, 2013-08, Vol.8 (8), p.1841-1851

2013

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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

PLoS pathogens, 2015-07, Vol.11 (7), p.e1005058-e1005058

2015

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Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

PloS one, 2019-12, Vol.14 (12), p.e0226270

2019

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Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

Antimicrobial Agents and Chemotherapy, 2010-08, Vol.54 (8), p.3326-3334

2010

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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

PloS one, 2010-04, Vol.5 (4), p.e10186

2010

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Molecular glues for protein-protein interactions: Progressing toward a new dream

Cell chemical biology, 2024-06, Vol.31 (6), p.1064-1088

2024

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Meet the authors: Markella Konstantinidou and Michelle R. Arkin

Cell chemical biology, 2024-06, Vol.31 (6), p.1027-1028

2024

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Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

SLAS discovery, 2024-07, Vol.29 (5), p.100165, Article 100165

2024

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Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

Proceedings of the National Academy of Sciences - PNAS, 2012-08, Vol.109 (34), p.13644-13649

2012

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Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH

ACS sensors, 2021-06, Vol.6 (6), p.2168-2180

2021

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Binding of Small Molecules to an Adaptive Protein-Protein Interface

Proceedings of the National Academy of Sciences - PNAS, 2003-02, Vol.100 (4), p.1603-1608

2003

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Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer

Current protocols, 2021-03, Vol.1 (3), p.e75-n/a

2021

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A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

Communications biology, 2020-12, Vol.3 (1), p.747-747, Article 747

2020

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High-Throughput Screening: today’s biochemical and cell-based approaches

Screening for noise in gene expression identifies drug synergies

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

Pharmacological brake-release of mRNA translation enhances cognitive memory

A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit

Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1

Altered cofactor regulation with disease-associated p97/VCP mutations

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia

A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons

A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease

Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II

Molecular glues for protein-protein interactions: Progressing toward a new dream

Meet the authors: Markella Konstantinidou and Michelle R. Arkin

Development of a NanoBRET assay for evaluation of 14-3-3σ molecular glues

Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis

Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH

Binding of Small Molecules to an Adaptive Protein-Protein Interface

Real‐Time Assessment of Mitochondrial Toxicity in HepG2 Cells Using the Seahorse Extracellular Flux Analyzer

A multi-dimensional, time-lapse, high content screening platform applied to schistosomiasis drug discovery

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