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DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

Molecular cell, 2012-11, Vol.48 (3), p.343-352

2012

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p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Cell reports (Cambridge), 2013-05, Vol.3 (5), p.1339-1345

2013

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Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Proceedings of the National Academy of Sciences - PNAS, 2015-07, Vol.112 (27), p.8409-8414

2015

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Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

The Journal of pathology, 2012-11, Vol.228 (3), p.300-309

2012

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p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Science (American Association for the Advancement of Science), 2003-11, Vol.302 (5647), p.1036-1038

2003

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The roles of DNA, RNA and histone methylation in ageing and cancer

Nature reviews. Molecular cell biology, 2019-10, Vol.20 (10), p.573

2019

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Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Nature Immunology, 2007-08, Vol.8 (8), p.856-863

2007

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Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

PLoS biology, 2018-08, Vol.16 (8), p.e2004986-e2004986

2018

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Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

The Journal of cell biology, 2007-02, Vol.176 (4), p.415-424

2007

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Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Molecular oncology, 2016-12, Vol.10 (10), p.1497-1515

2016

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Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

Molecular and Cellular Biology, 2005-10, Vol.25 (19), p.8732-8747

2005

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ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

Cell, 2007-06, Vol.129 (7), p.1337-1349

2007

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BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

The Journal of neuroscience, 2006-07, Vol.26 (27), p.7257-7264

2006

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Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Genes & development, 2010-08, Vol.24 (15), p.1608-1613

2010

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Using the GEMM-ESC strategy to study gene function in mouse models

Nature protocols, 2015-11, Vol.10 (11), p.1755-1785

2015

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BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Blood, 2005-12, Vol.106 (13), p.4131-4138

2005

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Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Blood, 2010-12, Vol.116 (24), p.5256-5267

2010

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Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells

EMBO molecular medicine, 2014-02, Vol.6 (2), p.212-225

2014

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The mammary stem cell field wakes up to hibernating cells

Stem cell investigation, 2017-05, Vol.4 (6), p.45-45

Michalak, Ewa M

2017

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A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

The Journal of cell biology, 2008-01, Vol.180 (2), p.341-355

2008

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Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Blood, 2013-10, Vol.122 (14), p.2402-2411

2013

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Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

The Journal of biological chemistry, 2013-02, Vol.288 (7), p.5198-5209

2013

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Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

Blood, 2006-09, Vol.108 (5), p.1461-1468

2006

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The BH3‐only Proteins Puma and Noxa: Two Brothers in Arms

Apoptosis and Cancer Therapy, 2006, p.379-402

2006

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DNA Damage-Induced Primordial Follicle Oocyte Apoptosis and Loss of Fertility Require TAp63-Mediated Induction of Puma and Noxa

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Selective resistance to the PARP inhibitor olaparib in a mouse model for BRCA1-deficient metaplastic breast cancer

Developmental stage-specific contribution of LGR5+ cells to basal and luminal epithelial lineages in the postnatal mammary gland

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

The roles of DNA, RNA and histone methylation in ageing and cancer

Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?

Mutually Exclusive Subsets of BH3-Only Proteins Are Activated by the p53 and c-Jun N-Terminal Kinase/c-Jun Signaling Pathways during Cortical Neuron Apoptosis Induced by Arsenite

ER Stress Triggers Apoptosis by Activating BH3-Only Protein Bim

BH3-Only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death

Apoptosis-promoted tumorigenesis: gamma-irradiation-induced thymic lymphomagenesis requires Puma-driven leukocyte death

Using the GEMM-ESC strategy to study gene function in mouse models

BH3-only proteins Puma and Bim are rate-limiting for γ-radiation– and glucocorticoid-induced apoptosis of lymphoid cells in vivo

Maximal killing of lymphoma cells by DNA damage–inducing therapy requires not only the p53 targets Puma and Noxa, but also Bim

Rapid target gene validation in complex cancer mouse models using re‐derived embryonic stem cells

The mammary stem cell field wakes up to hibernating cells

A Novel BH3 Ligand That Selectively Targets Mcl-1 Reveals That Apoptosis Can Proceed without Mcl-1 Degradation

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Transforming Growth Factor-β Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

The BH3‐only Proteins Puma and Noxa: Two Brothers in Arms

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