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Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil ® ) to Tumour Cells Using a Novel TIMP3 Peptide

Molecules (Basel, Switzerland), 2020-12, Vol.26 (1), p.100

2020

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Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site

Molecules (Basel, Switzerland), 2021-01, Vol.26 (3), p.625

2021

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Activity of matrix metalloproteinase‐9 against native collagen types I and III

The FEBS journal, 2007-03, Vol.274 (5), p.1246-1255

2007

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Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2

Genes & diseases, 2023-01, Vol.10 (1), p.45-47

2023

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Nature chemical biology, 2015-03, Vol.11 (3), p.189-191

2015

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Palladium-Catalyzed [1,3]-O-to-C Rearrangement of Pyrans toward Functionalized Cyclohexanones

Organic letters, 2010-11, Vol.12 (21), p.4832-4835

2010

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Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles

Bioorganic & medicinal chemistry letters, 2021-02, Vol.33, p.127752-127752, Article 127752

2021

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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

Journal of medicinal chemistry, 2016-02, Vol.59 (4), p.1370-1387

2016

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Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (21), p.3458-3462

2018

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Covalent targeting of non-cysteine residues in PI4KIIIβ

RSC chemical biology, 2023-11, Vol.4 (12), p.1111-1122

2023

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A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice

Angiogenesis (London), 2014-01, Vol.17 (1), p.207-219

2014

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Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors

Bioorganic & medicinal chemistry letters, 2016-10, Vol.26 (19), p.4606-4612

2016

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Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor

Bioorganic & medicinal chemistry letters, 2011-10, Vol.21 (20), p.6188-6194

2011

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Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5261-5265

2009

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4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

Bioorganic & medicinal chemistry letters, 2012-08, Vol.22 (16), p.5222-5226

2012

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The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins

Immunology, 2004-08, Vol.112 (4), p.590-596

2004

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4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Bioorganic & medicinal chemistry letters, 2009-05, Vol.19 (9), p.2504-2508

2009

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Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells

Human molecular genetics, 2005-12, Vol.14 (23), p.3579-3586

2005

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Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture

Journal of tissue engineering and regenerative medicine, 2010-12, Vol.4 (8), p.611-618

2010

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TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights

Expert reviews in molecular medicine, 2005-11, Vol.7 (24), p.1-15

2005

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A Novel Tissue Inhibitor of Metalloproteinases-3 Mutation Reveals a Common Molecular Phenotype in Sorsby's Fundus Dystrophy

The Journal of biological chemistry, 2000-09, Vol.275 (35), p.27027

2000

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Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5′ untranslated region in translational control

Gene, 2005-10, Vol.359, p.99-110

2005

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Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression

European journal of immunology, 2002-04, Vol.32 (4), p.1052-1058

2002

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Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients

Biochimica et biophysica acta, 2003-05, Vol.1638 (1), p.20-28

2003

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Specific Targeting of PEGylated Liposomal Doxorubicin (Doxil ® ) to Tumour Cells Using a Novel TIMP3 Peptide

Coupling of a Novel TIMP3 Peptide to Carboxypeptidase G2 for Pro-Drug Activation at the Tumour Site

Activity of matrix metalloproteinase‐9 against native collagen types I and III

Evidence that all Sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

Palladium-Catalyzed [1,3]-O-to-C Rearrangement of Pyrans toward Functionalized Cyclohexanones

Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6,5-bicyclic heterocycles

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4‑d]pyrimidin-4(3H)‑one Derivatives

Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3‑Amino-4-pyridine Carboxylate Derivatives

Covalent targeting of non-cysteine residues in PI4KIIIβ

A peptide derived from TIMP-3 inhibits multiple angiogenic growth factor receptors and tumour growth and inflammatory arthritis in mice

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors

Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy

The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors

Sorsby's fundus dystrophy mutations impair turnover of TIMP-3 by retinal pigment epithelial cells

Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture

TIMP3 mutation in Sorsby's fundus dystrophy: molecular insights

A Novel Tissue Inhibitor of Metalloproteinases-3 Mutation Reveals a Common Molecular Phenotype in Sorsby's Fundus Dystrophy

Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5′ untranslated region in translational control

Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression

Expression of mutant and wild-type TIMP3 in primary gingival fibroblasts from Sorsby's fundus dystrophy patients

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