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Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice

British journal of pharmacology, 2022-01, Vol.179 (1), p.46-64

2022

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Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine

Biopharmaceutics & drug disposition, 2022-12, Vol.43 (6), p.247-254

2022

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Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine

British journal of pharmacology, 2019-06, Vol.176 (11), p.1717-1727

2019

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Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Clinical and experimental pharmacology & physiology, 2014-12, Vol.41 (12), p.995-1002

2014

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Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Biomedicine & pharmacotherapy, 2019-07, Vol.115, p.108906, Article 108906

2019

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Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate

Biopharmaceutics & drug disposition, 2018-02, Vol.39 (2), p.88-98

2018

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The molecular mechanism underlying the induction of hepatic MRP3 expression and function by omeprazole

Biopharmaceutics & drug disposition, 2015-05, Vol.36 (4), p.232-244

2015

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P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a

Biochemical pharmacology, 2021-01, Vol.183, p.114313, Article 114313

2021

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Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

European journal of pharmacology, 2014-04, Vol.728, p.67-76

2014

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Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice

Life sciences (1973), 2021-08, Vol.279, p.119268-119268, Article 119268

2021

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Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway

Journal of thrombosis and haemostasis, 2023-01, Vol.21 (1), p.117-132

2023

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The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance

Molecular diagnosis & therapy, 2024-03, Vol.28 (2), p.189-199

2024

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Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1

Journal of thrombosis and haemostasis, 2023-05, Vol.21 (5), p.1322-1335

2023

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Development and validation of a UPLC–MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel

Journal of pharmaceutical and biomedical analysis, 2020-02, Vol.179, p.112955-112955, Article 112955

2020

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Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Clinical and experimental pharmacology & physiology, 2014-12, Vol.41 (12), p.995-1002

2014

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Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation

Journal of cardiovascular pharmacology, 2016-12, Vol.68 (6), p.433-440

2016

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Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice

Journal of cardiovascular pharmacology, 2018-11, Vol.72 (5), p.252-258

2018

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The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice

Xenobiotica, 2024-08, p.1-11

2024

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Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood

Drug metabolism and disposition, 2018-02, Vol.46 (2), p.151-154

2018

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Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model

Open life sciences, 2024-02, Vol.19 (1), p.20220825-20220825

2024

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Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5

Connective tissue research, 2020-11, Vol.61 (6), p.517-525

2020

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Platelet Aggregation Inhibitors - Pharmacology
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Is platelet responsiveness to clopidogrel attenuated in overweight or obese patients and why? A reverse translational study in mice

Vicagrel is hydrolyzed by Raf kinase inhibitor protein in human intestine

Enhanced responsiveness of platelets to vicagrel in IL‐10‐deficient mice through STAT3‐dependent up‐regulation of the hydrolase arylacetamide deacetylase in the intestine

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation

Human UGT2B7 is the major isoform responsible for the glucuronidation of clopidogrel carboxylate

The molecular mechanism underlying the induction of hepatic MRP3 expression and function by omeprazole

P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

Short-term standard alcohol consumption enhances platelet response to clopidogrel through inhibition of Nrf2/Ces1 pathway and induction of Cyp2c in mice

Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway

The Complement System and C4b-Binding Protein: A Focus on the Promise of C4BPα as a Biomarker to Predict Clopidogrel Resistance

Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1

Development and validation of a UPLC–MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel

Berberine attenuates adverse left ventricular remodeling and cardiac dysfunction after acute myocardial infarction in rats: Role of autophagy

Enhanced Platelet Response to Clopidogrel in Abcc3-deficient Mice Due to Its Increased Bioactivation

Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice

The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice

Mrp3 Transports Clopidogrel Acyl Glucuronide from the Hepatocytes into Blood

Application of the integrated airway humidification device enhances the humidification effect of the rabbit tracheotomy model

Histone demethylase Jmjd3 modulates osteoblast apoptosis induced by tumor necrosis factor-alpha through directly targeting RASSF5

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