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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

Bioorganic & medicinal chemistry letters, 2019-04, Vol.29 (8), p.1023-1029

2019

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A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

Cancer research (Chicago, Ill.), 2018-11, Vol.78 (22), p.6509-6522

2018

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The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

Cell chemical biology, 2018-09, Vol.25 (9), p.1107-1116.e4

2018

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Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1933-1933

2018

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Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Cancer discovery, 2018-05, Vol.8 (5), p.632-647

2018

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Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

Cancer research (Chicago, Ill.), 2018-04, Vol.78 (8), p.2096-2114

2018

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A Central Role for Biophysics in Cancer Drug Discovery - Development of Candidate Small Molecule Inhibitors in Mutant KRas

Biophysical journal, 2018-02, Vol.114 (3), p.30a-31a

2018

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Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.LB-228-LB-228

2017

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A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

Protein expression and purification, 2017-04, Vol.132, p.75-84

2017

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A novel small-molecule MRCK inhibitor blocks cancer cell invasion

Cell communication and signaling, 2014-10, Vol.12 (1), p.54, Article 54

2014

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5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

Bioorganic & medicinal chemistry, 2013-11, Vol.21 (22), p.6868-6877

2013

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Small molecules that bind the Mdm2 RING stabilize and activate p53

Carcinogenesis (New York), 2012-04, Vol.33 (4), p.791-798

2012

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Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

Journal of biomolecular screening, 2012-04, Vol.17 (4), p.460-468

2012

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Co-Crystal Structures of Inhibitors with MRCK[beta], a Key Regulator of Tumor Cell Invasion

PloS one, 2011-09, Vol.6 (9), p.e24825

2011

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Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

PloS one, 2011-09, Vol.6 (9), p.e24825

2011

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Discovery and Design of Protein Kinase Inhibitors: Targeting the Cell Cycle in Oncology

Protein Kinases as Drug Targets, 2011, p.229-270

2011

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Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents

Chemistry & biology, 2010-10, Vol.17 (10), p.1111-1121

2010

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Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Journal of medicinal chemistry, 2010-06, Vol.53 (11), p.4367-4378

2010

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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

Nature chemical biology, 2006-11, Vol.2 (11), p.608-617

2006

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Catch the Kinase Conformer

Chemistry & biology, 2006-07, Vol.13 (7), p.693-694

2006

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Differential Binding of Inhibitors to Active and Inactive CDK2 Provides Insights for Drug Design

Chemistry & biology, 2006-02, Vol.13 (2), p.201-211

2006

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Progress in the discovery of polo-like kinase inhibitors

Current topics in medicinal chemistry, 2005-01, Vol.5 (2), p.181-197

2005

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Synthesis and biological activity of 2-anilino-4-(1 H-pyrrol-3-yl) pyrimidine CDK inhibitors

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (16), p.4237-4240

2004

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Structural Determinants of CDK4 Inhibition and Design of Selective ATP Competitive Inhibitors

Chemistry & biology, 2004-04, Vol.11 (4), p.525-534

2004

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2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

Journal of medicinal chemistry, 2004-03, Vol.47 (7), p.1662-1675

2004

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Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents

A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma

The Meisenheimer Complex as a Paradigm in Drug Discovery: Reversible Covalent Inhibition through C67 of the ATP Binding Site of PLK1

Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells in vitro and in vivo

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer

A Central Role for Biophysics in Cancer Drug Discovery - Development of Candidate Small Molecule Inhibitors in Mutant KRas

Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery

A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

5-Deazaflavin derivatives as inhibitors of p53 ubiquitination by HDM2

Small molecules that bind the Mdm2 RING stabilize and activate p53

Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

Co-Crystal Structures of Inhibitors with MRCK[beta], a Key Regulator of Tumor Cell Invasion

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

Discovery and Design of Protein Kinase Inhibitors: Targeting the Cell Cycle in Oncology

Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents

Discovery of N-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

Catch the Kinase Conformer

Differential Binding of Inhibitors to Active and Inactive CDK2 Provides Insights for Drug Design

Progress in the discovery of polo-like kinase inhibitors

Synthesis and biological activity of 2-anilino-4-(1 H-pyrrol-3-yl) pyrimidine CDK inhibitors

Structural Determinants of CDK4 Inhibition and Design of Selective ATP Competitive Inhibitors

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors: Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

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