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The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes

PLoS pathogens, 2013-01, Vol.9 (1), p.e1003125-e1003125

2013

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Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts

Current topics in medicinal chemistry, 2012-03, Vol.12 (5), p.445-455

2012

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Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

PLoS neglected tropical diseases, 2018-01, Vol.12 (1), p.e0006183-e0006183

2018

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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity

Antimicrobial agents and chemotherapy, 2015-02, Vol.59 (2), p.1070-1079

2015

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The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis

PloS one, 2017-10, Vol.12 (10), p.e0185906-e0185906

2017

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The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition

Frontiers in oncology, 2023-10, Vol.13, p.1295185-1295185

2023

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Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity

Antiviral research, 2014-08, Vol.108, p.48-55

2014

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Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H

ACS infectious diseases, 2019-05, Vol.5 (5), p.655-658

2019

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Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)

Journal of medicinal chemistry, 2007-05, Vol.50 (11), p.2647-2654

2007

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Repurposing and optimization of drugs for discovery of novel antifungals

Drug discovery today, 2022-07, Vol.27 (7), p.2008-2014

2022

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Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy

Journal of medicinal chemistry, 2010-08, Vol.53 (16), p.5979-6002

2010

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Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Nature structural & molecular biology, 2002-05, Vol.9 (5), p.359-364

2002

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Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

ACS omega, 2018-11, Vol.3 (11), p.15125-15133

2018

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Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

ACS omega, 2021-10, Vol.6 (42), p.27630-27639

2021

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Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Science (American Association for the Advancement of Science), 2017-10, Vol.358 (6362), p.518-522

2017

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Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans

ACS omega, 2021-03, Vol.6 (12), p.8477-8487

2021

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Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Molecular metabolism (Germany), 2017-07, Vol.6 (7), p.703-714

2017

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Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection

Antimicrobial agents and chemotherapy, 2021-11, Vol.65 (12), p.e0146021

2021

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Identification of 4-Amino-Thieno[2,3- d ]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

mSphere, 2019-09, Vol.4 (5)

2019

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CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

Antimicrobial agents and chemotherapy, 2023-10, Vol.67 (10), p.e0056723-e0056723

2023

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Synthesis and Antifungal Activity of Stereoisomers of Mefloquine Analogs

ACS medicinal chemistry letters, 2024-06, Vol.15 (6), p.822-827

2024

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Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633

Bioorganic & medicinal chemistry, 2023-05, Vol.86, p.117295-117295, Article 117295

2023

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Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance

Proceedings of the National Academy of Sciences - PNAS, 2024-02, Vol.121 (9), p.e2312987121

2024

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Structure–Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine

Journal of medicinal chemistry, 2023-06, Vol.66 (12), p.7834-7848

2023

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Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development

Antimicrobial agents and chemotherapy, 2019-03, Vol.63 (3)

2019

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The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes

Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts

Clinical and microbiologic efficacy of the piperazine-based drug lead MMV665917 in the dairy calf cryptosporidiosis model

Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity

The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis

The anti-cancer efficacy of a novel phenothiazine derivative is independent of dopamine and serotonin receptor inhibition

Hepatitis B virus replication is blocked by a 2-hydroxyisoquinoline-1,3(2H,4H)-dione (HID) inhibitor of the viral ribonuclease H activity

Chemical Approaches to Inhibiting the Hepatitis B Virus Ribonuclease H

Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)

Repurposing and optimization of drugs for discovery of novel antifungals

Discovery of (3S,3aR)-2-(3-Chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic Acid (PF-3882845), an Orally Efficacious Mineralocorticoid Receptor (MR) Antagonist for Hypertension and Nephropathy

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

Mechanism of Action of N -Acyl and N -Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum , a Causative Agent of Malaria

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion

Synthetic Derivatives of Ciclopirox are Effective Inhibitors of Cryptococcus neoformans

Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection

Identification of 4-Amino-Thieno[2,3- d ]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

CWHM-974 is a fluphenazine derivative with improved antifungal activity against Candida albicans due to reduced susceptibility to multidrug transporter-mediated resistance mechanisms

Synthesis and Antifungal Activity of Stereoisomers of Mefloquine Analogs

Structure-Activity relationships of replacements for the triazolopyridazine of Anti-Cryptosporidium lead SLU-2633

Comparative chemical genomics in Babesia species identifies the alkaline phosphatase PhoD as a determinant of antiparasitic resistance

Structure–Activity Relationship Studies of the Aryl Acetamide Triazolopyridazines against Cryptosporidium Reveals Remarkable Role of Fluorine

Endonuclease Activity Inhibition of the NS1 Protein of Parvovirus B19 as a Novel Target for Antiviral Drug Development

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