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Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

Cytokine & growth factor reviews, 2015-08, Vol.26 (4), p.425-449

2015

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Critical domains for NACC2-NTRK2 fusion protein activation

PloS one, 2024-06, Vol.19 (6), p.e0301730

2024

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Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation

Molecular cancer research, 2016-05, Vol.14 (5), p.458-469

2016

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Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation

Haematologica (Roma), 2020-05, Vol.105 (5), p.1262-1273

2020

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The oncogenic fusion protein EML4-NTRK3 requires three salt bridges for stability and biological activity

Heliyon, 2024-08, Vol.10 (16), p.e36278, Article e36278

2024

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The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling

PloS one, 2010-12, Vol.5 (12), p.e14412-e14412

2010

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Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors

Translational oncology, 2020-12, Vol.13 (12), p.100853-100853, Article 100853

2020

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Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

PloS one, 2018-10, Vol.13 (10), p.e0206014-e0206014

2018

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Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer

PloS one, 2014, Vol.9 (1), p.e86470-e86470

2014

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Early human prostate adenocarcinomas harbor androgen-independent cancer cells

PloS one, 2013-09, Vol.8 (9), p.e74438-e74438

2013

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Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk

Cytokine & growth factor reviews, 2022-12, Vol.68, p.93-106

2022

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Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Oncogene, 2000-07, Vol.19 (29), p.3309-3320

2000

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Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment

Oncotarget, 2021-01, Vol.12 (1), p.22-36

2021

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Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKβ

PloS one, 2013-12, Vol.8 (12), p.e84497

2013

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Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation

Oncotarget, 2022, Vol.13 (1), p.659-676

2022

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Nuclear Localization of Cyclin B1 Mediates its Biological Activity and is Regulated by Phosphorylation

Proceedings of the National Academy of Sciences - PNAS, 1997-01, Vol.94 (2), p.502-507

1997

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Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders

Trends in molecular medicine, 2017-01, Vol.23 (1), p.59-79

2017

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Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability

Oncotarget, 2023-02, Vol.14 (1), p.133-145

2023

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Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase

Molecular biology of the cell, 2000-10, Vol.11 (10), p.3589-3599

2000

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Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling

Oncotarget, 2018-09, Vol.9 (76), p.34306-34319

2018

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Spy1 Enhances Phosphorylation and Degradation of the Cell Cycle Inhibitor p27

Cell cycle (Georgetown, Tex.), 2007-08, Vol.6 (15), p.1937-1945

2007

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Typical achondroplasia secondary to a unique insertional variant of FGFR3 with in vitro demonstration of its effect on FGFR3 function

American journal of medical genetics. Part A, 2021-03, Vol.185 (3), p.798-805

2021

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Activating Mutations in the Extracellular Domain of the Fibroblast Growth Factor Receptor 2 Function by Disruption of the Disulfide Bond in the Third Immunoglobulin-Like Domain

Proceedings of the National Academy of Sciences - PNAS, 1998-04, Vol.95 (8), p.4567-4572

1998

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Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling

Cell cycle (Georgetown, Tex.), 2014-12, Vol.13 (24), p.3964-3976

2014

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Characterization of iPS87, a prostate cancer stem cell-like cell line

Oncotarget, 2020-03, Vol.11 (12), p.1075-1084

2020

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Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

Critical domains for NACC2-NTRK2 fusion protein activation

Oncogenic Gene Fusion FGFR3-TACC3 Is Regulated by Tyrosine Phosphorylation

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation

The oncogenic fusion protein EML4-NTRK3 requires three salt bridges for stability and biological activity

The receptor tyrosine kinase FGFR4 negatively regulates NF-kappaB signaling

Oncogenic fusion protein FGFR2-PPHLN1: Requirements for biological activation, and efficacy of inhibitors

Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

Fibroblast growth factor receptor 3 interacts with and activates TGFβ-activated kinase 1 tyrosine phosphorylation and NFκB signaling in multiple myeloma and bladder cancer

Early human prostate adenocarcinomas harbor androgen-independent cancer cells

Nefarious NTRK oncogenic fusions in pediatric sarcomas: Too many to Trk

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Characterization of FGFR signaling in prostate cancer stem cells and inhibition via TKI treatment

Tyrosine phosphorylation allows integration of multiple signaling inputs by IKKβ

Proteomic analysis reveals dual requirement for Grb2 and PLCγ1 interactions for BCR-FGFR1-Driven 8p11 cell proliferation

Nuclear Localization of Cyclin B1 Mediates its Biological Activity and is Regulated by Phosphorylation

Receptor Tyrosine Kinases: Translocation Partners in Hematopoietic Disorders

Oncogenic driver FGFR3-TACC3 requires five coiled-coil heptads for activation and disulfide bond formation for stability

Rotational coupling of the transmembrane and kinase domains of the Neu receptor tyrosine kinase

Oncogenic driver FGFR3-TACC3 is dependent on membrane trafficking and ERK signaling

Spy1 Enhances Phosphorylation and Degradation of the Cell Cycle Inhibitor p27

Typical achondroplasia secondary to a unique insertional variant of FGFR3 with in vitro demonstration of its effect on FGFR3 function

Activating Mutations in the Extracellular Domain of the Fibroblast Growth Factor Receptor 2 Function by Disruption of the Disulfide Bond in the Third Immunoglobulin-Like Domain

Novel Lys63-linked ubiquitination of IKKβ induces STAT3 signaling

Characterization of iPS87, a prostate cancer stem cell-like cell line

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