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Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes

Stem cell reports, 2014-10, Vol.3 (4), p.594-605

2014

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Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Biochimica et biophysica acta, 2016-07, Vol.1863 (7), p.1829-1838

2016

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Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

PloS one, 2018-04, Vol.13 (4), p.e0194909-e0194909

2018

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Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia

Scientific reports, 2021-12, Vol.11 (1), p.23627-23627, Article 23627

2021

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A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

Cell, 2016-05, Vol.165 (5), p.1147-1159

2016

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Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization

Journal of molecular and cellular cardiology, 2014-02, Vol.67, p.26-37

2014

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Duchenne muscular dystrophy: disease mechanism and therapeutic strategies

Frontiers in physiology, 2023-06, Vol.14, p.1183101-1183101

2023

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Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies

Journal of clinical medicine, 2020-02, Vol.9 (2), p.520

2020

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Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain

Scientific reports, 2024-02, Vol.14 (1), p.3915-3915, Article 3915

2024

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The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere

Journal of molecular and cellular cardiology, 2022-09, Vol.170, p.117-120

Metzger, Joseph M.

2022

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Cardiac Sarcomere Signaling in Health and Disease

International journal of molecular sciences, 2022-12, Vol.23 (24), p.16223

2022

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Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

Scientific reports, 2022-10, Vol.12 (1), p.18116-18116, Article 18116

2022

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An integrative genomics approach to infer causal associations between gene expression and disease

Nature genetics, 2005-07, Vol.37 (7), p.710-717

2005

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Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

Journal of the American Heart Association, 2017-05, Vol.6 (6)

2017

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Dystrophic heart failure blocked by membrane sealant poloxamer

Nature, 2005-08, Vol.436 (7053), p.1025-1029

2005

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Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

Skeletal muscle, 2018-10, Vol.8 (1), p.31-31, Article 31

2018

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Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex

The FASEB journal, 2011-09, Vol.25 (9), p.3106-3114

2011

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ER71 directs mesodermal fate decisions during embryogenesis

Development (Cambridge), 2011-11, Vol.138 (21), p.4801-4812

2011

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Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains

Physiological genomics, 2010-10, Vol.42A (2), p.103-113

2010

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Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

The Journal of clinical investigation, 2010-04, Vol.120 (4), p.1140-1150

2010

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Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling

PloS one, 2013-10, Vol.8 (10), p.e78768-e78768

2013

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Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit

Thrombosis and haemostasis, 2014-04, Vol.111 (4), p.694

2014

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KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

Proceedings of the National Academy of Sciences - PNAS, 2007-03, Vol.104 (10), p.3943-3948

2007

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Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts

PloS one, 2012-03, Vol.7 (3), p.e32880-e32880

2012

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Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies

Biochimica et biophysica acta, 2013-04, Vol.1833 (4), p.895-900

2013

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Acquisition of a Quantitative, Stoichiometrically Conserved Ratiometric Marker of Maturation Status in Stem Cell-Derived Cardiac Myocytes

Maturation status of sarcomere structure and function in human iPSC-derived cardiac myocytes

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

Cardiac myocyte intrinsic contractility and calcium handling deficits underlie heart organ dysfunction in murine cancer cachexia

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization

Duchenne muscular dystrophy: disease mechanism and therapeutic strategies

Dysregulation of Calcium Handling in Duchenne Muscular Dystrophy-Associated Dilated Cardiomyopathy: Mechanisms and Experimental Therapeutic Strategies

Inducing positive inotropy in human iPSC-derived cardiac muscle by gene editing-based activation of the cardiac α-myosin heavy chain

The road to physiological maturation of stem cell-derived cardiac muscle runs through the sarcomere

Cardiac Sarcomere Signaling in Health and Disease

Sarcomere dynamics revealed by a myofilament integrated FRET-based biosensor in live skeletal muscle fibers

An integrative genomics approach to infer causal associations between gene expression and disease

Colchicine Depolymerizes Microtubules, Increases Junctophilin-2, and Improves Right Ventricular Function in Experimental Pulmonary Arterial Hypertension

Dystrophic heart failure blocked by membrane sealant poloxamer

Muscle membrane integrity in Duchenne muscular dystrophy: recent advances in copolymer-based muscle membrane stabilizers

Distinct pathophysiological mechanisms of cardiomyopathy in hearts lacking dystrophin or the sarcoglycan complex

ER71 directs mesodermal fate decisions during embryogenesis

Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains

Chronic administration of membrane sealant prevents severe cardiac injury and ventricular dilatation in dystrophic dogs

Direct, differential effects of tamoxifen, 4-hydroxytamoxifen, and raloxifene on cardiac myocyte contractility and calcium handling

Factor XIIa inhibition by Infestin-4: in vitro mode of action and in vivo antithrombotic benefit

KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging

Ex vivo stretch reveals altered mechanical properties of isolated dystrophin-deficient hearts

Calcium mishandling in diastolic dysfunction: Mechanisms and potential therapies

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