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Neutrophils dominate the immune cell composition in non-small cell lung cancer

Nature communications, 2017-02, Vol.8 (1), p.14381-14381, Article 14381

2017

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Lung Cancer Subtypes Generate Unique Immune Responses

The Journal of immunology (1950), 2016-12, Vol.197 (11), p.4493-4503

2016

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Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

Journal of leukocyte biology, 2015-08, Vol.98 (2), p.143-152

2015

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Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non-Small Cell Lung Cancer

American journal of respiratory and critical care medicine, 2018-02, Vol.197 (3), p.325-336

2018

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Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

Nature medicine, 2010-02, Vol.16 (2), p.219-223

2010

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Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase

Clinical cancer research, 2011-01, Vol.17 (2), p.206-211

2011

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Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma

Proceedings of the National Academy of Sciences - PNAS, 2016-08, Vol.113 (31), p.8795-8800

2016

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712 SBT6290, a systemically administered Nectin-4-directed TLR8 ImmunoTAC (TM) therapeutic, is a potent human myeloid cell agonist for the treatment of Nectin-4-expressing tumors

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A754-A754

2020

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Analytical Validation of Digital Spatial Profiling - a novel approach for multiplexed characterization of protein distribution and abundance in FFPE tissue sections

The Journal of immunology (1950), 2018-05, Vol.200 (1_Supplement), p.174-174.23

2018

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Abstract 4537: SBT6050, a HER2-directed TLR8 ImmunoTAC™therapeutic, is a potent human myeloid cell agonist that provides opportunity for single agent clinical activity

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4537-4537

2020

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SBT6050, a HER2-directed TLR8 therapeutic, as a systemically administered, tumor-targeted human myeloid cell agonist

Journal of clinical oncology, 2020-05, Vol.38 (15_suppl), p.3110-3110

2020

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Abstract C15: Neutrophil elastase (NE) induces epithelial-mesenchymal transition (EMT) via upregulation of inhibitor of DNA binding 1 (ID1)

Cancer research (Chicago, Ill.), 2016-08, Vol.76 (15_Supplement), p.C15-C15

2016

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Abstract B26: Novel pro-host role for insulin receptor substrate-1 in lung adenocarcinoma

Cancer research (Chicago, Ill.), 2016-08, Vol.76 (15_Supplement), p.B26-B26

2016

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Abstract PD4-09: Preclinical studies support the development of SBT6050, an anti-HER2 antibody conjugated to a potent TLR8 agonist, for treatment of moderate and high HER2-expressing tumors that lack pre-existing T cell infiltrate

Cancer research (Chicago, Ill.), 2020-02, Vol.80 (4_Supplement), p.PD4-09-PD4-09

2020

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Abstract 1858: SBT6290, a systemically administered Nectin4-directed TLR8 ImmunoTAC™ product candidate, is designed for tumor-localized activation of myeloid cells

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.1858-1858

2021

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Abstract 3858: Validation of digital spatial profiling of key immuno-oncology targets for mouse FFPE preclinical models

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.3858-3858

2018

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Abstract 2354: Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.2354-2354

2015

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Abstract PR04: Inflammatory responses within the lung tumor microenvironment correlate with oncogenic mutation and histologic subtype

Cancer research (Chicago, Ill.), 2016-08, Vol.76 (15_Supplement), p.PR04-PR04

2016

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P2‐104: PRECISE MORPHOLOGICAL MAPPING OF HIGH PLEX NEURODEGENERATIVE AND NEUROINFLAMMATION PROTEIN TARGETS IN HUMAN FFPE BRAIN TISSUE WITH THE GEOMX™ DIGITAL SPATIAL PROFILER

Alzheimer's & dementia, 2019-07, Vol.15 (7S_Part_12), p.P612-P612

2019

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PRECISE MORPHOLOGICAL MAPPING OF HIGH PLEX NEURODEGENERATIVE AND NEUROINFLAMMATION PROTEIN TARGETS IN HUMAN FFPE BRAIN TISSUE WITH THE GEOMX™ DIGITAL SPATIAL PROFILER

Alzheimer's & dementia, 2019-07, Vol.15 (7), p.P612-P612

2019

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Abstract 1290: Distinct immune cell composition for lung squamous cell carcinoma (SCCA) and adenocarcinoma (ADCA)

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.1290-1290

2015

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Abstract 4860: Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma

Cancer research (Chicago, Ill.), 2014-10, Vol.74 (19_Supplement), p.4860-4860

2014

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Non-canonical role for Insulin Receptor Substrate-1 in signaling pathways of the lung

Metz, Heather Elizabeth

2015

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Restorative justice and educating for peace

Metz, Heather

2008

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The dominant school language narrative: Unpacking English teachers' language ideologies

Language (Baltimore), 2021-09, Vol.97 (3), p.e238-e256

2021

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Neutrophils dominate the immune cell composition in non-small cell lung cancer

Lung Cancer Subtypes Generate Unique Immune Responses

Neutrophil elastase promotes myofibroblast differentiation in lung fibrosis

Chronic Obstructive Pulmonary Disease Alters Immune Cell Composition and Immune Checkpoint Inhibitor Efficacy in Non-Small Cell Lung Cancer

Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth

Insulin Receptor Substrate Regulation of Phosphoinositide 3-Kinase

Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma

712 SBT6290, a systemically administered Nectin-4-directed TLR8 ImmunoTAC (TM) therapeutic, is a potent human myeloid cell agonist for the treatment of Nectin-4-expressing tumors

Analytical Validation of Digital Spatial Profiling - a novel approach for multiplexed characterization of protein distribution and abundance in FFPE tissue sections

Abstract 4537: SBT6050, a HER2-directed TLR8 ImmunoTAC™therapeutic, is a potent human myeloid cell agonist that provides opportunity for single agent clinical activity

SBT6050, a HER2-directed TLR8 therapeutic, as a systemically administered, tumor-targeted human myeloid cell agonist

Abstract C15: Neutrophil elastase (NE) induces epithelial-mesenchymal transition (EMT) via upregulation of inhibitor of DNA binding 1 (ID1)

Abstract B26: Novel pro-host role for insulin receptor substrate-1 in lung adenocarcinoma

Abstract PD4-09: Preclinical studies support the development of SBT6050, an anti-HER2 antibody conjugated to a potent TLR8 agonist, for treatment of moderate and high HER2-expressing tumors that lack pre-existing T cell infiltrate

Abstract 1858: SBT6290, a systemically administered Nectin4-directed TLR8 ImmunoTAC™ product candidate, is designed for tumor-localized activation of myeloid cells

Abstract 3858: Validation of digital spatial profiling of key immuno-oncology targets for mouse FFPE preclinical models

Abstract 2354: Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma

Abstract PR04: Inflammatory responses within the lung tumor microenvironment correlate with oncogenic mutation and histologic subtype

P2‐104: PRECISE MORPHOLOGICAL MAPPING OF HIGH PLEX NEURODEGENERATIVE AND NEUROINFLAMMATION PROTEIN TARGETS IN HUMAN FFPE BRAIN TISSUE WITH THE GEOMX™ DIGITAL SPATIAL PROFILER

PRECISE MORPHOLOGICAL MAPPING OF HIGH PLEX NEURODEGENERATIVE AND NEUROINFLAMMATION PROTEIN TARGETS IN HUMAN FFPE BRAIN TISSUE WITH THE GEOMX™ DIGITAL SPATIAL PROFILER

Abstract 1290: Distinct immune cell composition for lung squamous cell carcinoma (SCCA) and adenocarcinoma (ADCA)

Abstract 4860: Insulin receptor substrate-1 regulates immune cell content in lung adenocarcinoma

Non-canonical role for Insulin Receptor Substrate-1 in signaling pathways of the lung

Restorative justice and educating for peace

The dominant school language narrative: Unpacking English teachers' language ideologies

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