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Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities

Clinical pharmacology and therapeutics, 2015-01, Vol.97 (1), p.37-54

2015

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Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Clinical pharmacology and therapeutics, 2017-04, Vol.101 (4), p.501-509

2017

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Predicting QRS and PR interval prolongations in humans using nonclinical data

British journal of pharmacology, 2017-10, Vol.174 (19), p.3268-3283

2017

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Translational Modeling of Drug‐Induced Myelosuppression and Effect of Pretreatment Myelosuppression for AZD5153, a Selective BRD4 Inhibitor

CPT: pharmacometrics and systems pharmacology, 2017-06, Vol.6 (6), p.357-364

2017

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Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

CPT: pharmacometrics and systems pharmacology, 2015-03, Vol.4 (3), p.175-188

2015

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Impact of a five-dimensional framework on R&D productivity at AstraZeneca

Nature reviews. Drug discovery, 2018-03, Vol.17 (3), p.167-181

2018

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493 Preclinical pharmacokinetic (PK)/pharmacodynamic (PD)/Efficacy modeling for MLN2480, an investigational pan-RAF kinase inhibitor, in A375 and SKMEL-2 human melanoma xenografts

European journal of cancer (1990), 2014-11, Vol.50, p.161-161

2014

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A Systems-Level Analysis of Perfect Adaptation in Yeast Osmoregulation

Cell, 2009-07, Vol.138 (1), p.160-171

2009

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256 Mechanism-based Preclinical PK/PD/E Relationships for Alisertib, an Investigational Small-molecule Inhibitor of Aurora A Kinase, in a Range of Human Solid Tumor Xenografts

European journal of cancer (1990), 2012-11, Vol.48, p.78-79

2012

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Coarsening dynamics of a quasi–one-dimensional driven lattice gas

Europhysics letters, 2002-06, Vol.58 (5), p.653-659

2002

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Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Annual review of pharmacology and toxicology, 2018-01, Vol.58, p.65

2018

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Acute HIV infection after acupuncture treatments

The New England journal of medicine, 1989-01, Vol.320 (4), p.250

1989

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Translational Modeling of Drug-Induced Myelosuppression and Effect of Pretreatment Myelosuppression for AZD5153, a Selective BRD4 Inhibitor: Translational Modeling of Drug-Induced Myelosuppression

CPT: pharmacometrics and systems pharmacology, 2017-06, Vol.6 (6), p.357-364

2017

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Factors correlated with homosexually acquired human immunodeficiency virus infection in the era of safer sex : was the prevention message clear and well understood ?

Sexually transmitted diseases, 1993, Vol.20 (1), p.51-58

1993

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Bridge and poker

Le Chirurgien-dentiste de France, 1989-09, Vol.59 (486), p.25

1989

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Prophylaxie de la pneumopathie à Pneumocystis carinii : utilisation des aérosols de pentamidine à domicile

Médecine et maladies infectieuses, 1992-05, Vol.22 (5), p.513-517

1992

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AZT in community practice

Therapie, 1989-11, Vol.44 (6), p.413

1989

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Longitudinal study of plasma HIV-1 RNA concentrations during the asymptomatic stage of HIV infection measured using AMPLICOR HIV monitor and NASBA HIV-1 RNA QT tests

Journal of medical virology, 1998-01, Vol.54 (1), p.60-68

1998

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Factors correlated with homosexually acquired human immunodeficiency virus infection in the era of "safer sex". Was the prevention message clear and well understood? Alain Brugeat Physician Group

Sexually transmitted diseases, 1993-01, Vol.20 (1), p.51-58

1993

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Value of retroperitoneal lymphadenectomy after chemotherapy for non-seminomatous testicular tumor with lymph node metastases

Progress in clinical and biological research, 1989, Vol.303, p.813

1989

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Unusual modes of HIV transmission

The New England journal of medicine, 1989-11, Vol.321 (21), p.1476

1989

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On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Scientific reports, 2019-07, Vol.9 (1), p.9619-14, Article 9619

2019

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Orient-Express et Cie : histoire et patrimonialisation d’une marque ferroviaire (19e-21e siècles)

L'atelier du Centre de recherches historiques, 2022-12

Mettetal, Arthur

2022

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Le genre des carrières: Inégalités dans l’administration culturelle

Revue des politiques sociales et familiales, 2024-01, Vol.n°149 (4), p.149-151

Mettetal, Barbara

2024

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Optimizing Oncology Therapeutics Through Quantitative Translational and Clinical Pharmacology: Challenges and Opportunities

Systems pharmacology modeling of drug‐induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters

Predicting QRS and PR interval prolongations in humans using nonclinical data

Translational Modeling of Drug‐Induced Myelosuppression and Effect of Pretreatment Myelosuppression for AZD5153, a Selective BRD4 Inhibitor

Modeling and Simulation Approaches for Cardiovascular Function and Their Role in Safety Assessment

Impact of a five-dimensional framework on R&D productivity at AstraZeneca

493 Preclinical pharmacokinetic (PK)/pharmacodynamic (PD)/Efficacy modeling for MLN2480, an investigational pan-RAF kinase inhibitor, in A375 and SKMEL-2 human melanoma xenografts

A Systems-Level Analysis of Perfect Adaptation in Yeast Osmoregulation

256 Mechanism-based Preclinical PK/PD/E Relationships for Alisertib, an Investigational Small-molecule Inhibitor of Aurora A Kinase, in a Range of Human Solid Tumor Xenografts

Coarsening dynamics of a quasi–one-dimensional driven lattice gas

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Preclinical Pharmacokinetic/Pharmacodynamic Modeling and Simulation in the Pharmaceutical Industry: An IQ Consortium Survey Examining the Current Landscape

Acute HIV infection after acupuncture treatments

Translational Modeling of Drug-Induced Myelosuppression and Effect of Pretreatment Myelosuppression for AZD5153, a Selective BRD4 Inhibitor: Translational Modeling of Drug-Induced Myelosuppression

Factors correlated with homosexually acquired human immunodeficiency virus infection in the era of safer sex : was the prevention message clear and well understood ?

Bridge and poker

Prophylaxie de la pneumopathie à Pneumocystis carinii : utilisation des aérosols de pentamidine à domicile

AZT in community practice

Longitudinal study of plasma HIV-1 RNA concentrations during the asymptomatic stage of HIV infection measured using AMPLICOR HIV monitor and NASBA HIV-1 RNA QT tests

Factors correlated with homosexually acquired human immunodeficiency virus infection in the era of "safer sex". Was the prevention message clear and well understood? Alain Brugeat Physician Group

Value of retroperitoneal lymphadenectomy after chemotherapy for non-seminomatous testicular tumor with lymph node metastases

Unusual modes of HIV transmission

On the potential of in vitro organ-chip models to define temporal pharmacokinetic-pharmacodynamic relationships

Orient-Express et Cie : histoire et patrimonialisation d’une marque ferroviaire (19e-21e siècles)

Le genre des carrières: Inégalités dans l’administration culturelle

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