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PRMT5 is essential for B cell development and germinal center dynamics

Nature communications, 2019-01, Vol.10 (1), p.22-17, Article 22

2019

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Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

The Journal of cell biology, 2019-03, Vol.218 (3), p.820-838

2019

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A licensing step links AID to transcription elongation for mutagenesis in B cells

Nature communications, 2018-03, Vol.9 (1), p.1248-16, Article 1248

2018

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Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

Proceedings of the National Academy of Sciences - PNAS, 2014-03, Vol.111 (11), p.3911-3911

2014

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Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

The EMBO journal, 2012-02, Vol.31 (3), p.679-691

2012

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Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

Genes & development, 2019-04, Vol.33 (7-8), p.436-451

2019

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Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin

PloS one, 2013-10, Vol.8 (10), p.e76832

2013

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H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

Nature cell biology, 2021-11, Vol.23 (11), p.1163

2021

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SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Nature structural & molecular biology, 2022-02, Vol.29 (2), p.85

2022

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Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

The Journal of experimental medicine, 2023-09, Vol.220 (9)

2023

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Guanine-Rich RNAs and DNAs That Bind Heme Robustly Catalyze Oxygen Transfer Reactions

Journal of the American Chemical Society, 2011-02, Vol.133 (6), p.1877-1884

2011

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AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Blood, 2021-07, Vol.138 (3), p.246-258

2021

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Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

The Journal of experimental medicine, 2015-04, Vol.212 (4), p.581-596

2015

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A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

Journal of molecular biology, 2013-01, Vol.425 (2), p.424-443

2013

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Pharmacological manipulation of AID

Oncotarget, 2015-09, Vol.6 (29), p.26550-26551

2015

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Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

The Journal of cell biology, 2015-04, Vol.209 (1), p.2091

2015

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Nuclear Exclusion of AID Limits off Target Activity by Enforcing Productive Targeting

Methot, Stephen P

2017

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Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1: Non-redundant role of DnaJa1 in stabilizing AID

The EMBO journal, 2012-02, Vol.31 (3), p.679-691

2012

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Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.5137-5156

2021

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Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2254-2254

2019

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X-linked Inhibitor of Apoptosis Regulates T Cell Effector Function

The Journal of immunology (1950), 2007-12, Vol.179 (11), p.7553-7560

2007

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Multiplex Relationships in Organizations: Applying an Ambivalence Lens

Social Networks at Work, 2020, p.79-103

1, 2020

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PRMT5 is essential for B cell development and germinal center dynamics

Heterochromatic foci and transcriptional repression by an unstructured MET-2/SETDB1 co-factor LIN-65

A licensing step links AID to transcription elongation for mutagenesis in B cells

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1

Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

Targeting the tumour vasculature: exploitation of low oxygenation and sensitivity to NOS inhibition by treatment with a hypoxic cytotoxin

H3K9me selectively blocks transcription factor activity and ensures differentiated tissue integrity

SETDB1-like MET-2 promotes transcriptional silencing and development independently of its H3K9me-associated catalytic activity

Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice

Guanine-Rich RNAs and DNAs That Bind Heme Robustly Catalyze Oxygen Transfer Reactions

AID overexpression leads to aggressive murine CLL and nonimmunoglobulin mutations that mirror human neoplasms

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

Pharmacological manipulation of AID

Consecutive interactions with HSP90 and eEF1A underlie a functional maturation and storage pathway of AID in the cytoplasm

Nuclear Exclusion of AID Limits off Target Activity by Enforcing Productive Targeting

Optimal functional levels of activation-induced deaminase specifically require the Hsp40 DnaJa1: Non-redundant role of DnaJa1 in stabilizing AID

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators

Abstract 2254: Solid tumor activity with a selective PI3Kdelta inhibitor as a single agent and in combination with anti-PD-1

X-linked Inhibitor of Apoptosis Regulates T Cell Effector Function

Multiplex Relationships in Organizations: Applying an Ambivalence Lens

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