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Human Immunodeficiency Virus Protease Expressed in Escherichia coli Exhibits Autoprocessing and Specific Maturation of the Gag Precursor

Proceedings of the National Academy of Sciences - PNAS, 1987-12, Vol.84 (24), p.8903-8906

1987

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Inhibition of Human Immunodeficiency Virus 1 Protease in vitro: Rational Design of Substrate Analogue Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1989-12, Vol.86 (24), p.9752-9756

1989

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Human Immunodeficiency Virus 1 Protease Expressed in Escherichia coli Behaves as a Dimeric Aspartic Protease

Proceedings of the National Academy of Sciences - PNAS, 1989-03, Vol.86 (6), p.1841-1845

1989

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Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, x-ray crystallography, and infected T-cell assays

Biochemistry (Easton), 1992-07, Vol.31 (29), p.6646-6659

1992

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Human immunodeficiency virus type 1 protease inhibitors irreversibly block infectivity of purified virions from chronically infected cells

Antimicrobial Agents and Chemotherapy, 1992-05, Vol.36 (5), p.982-988

1992

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The impact of genomics on medicinal chemistry

Pure and applied chemistry, 1998-02, Vol.70 (2), p.359-363

Metcalf, B. W.

1998

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Peptide substrates and inhibitors of the HIV-1 protease

Biochemical and biophysical research communications, 1989-03, Vol.159 (2), p.420-425

1989

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Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

Journal of the American Chemical Society, 1978-04, Vol.100 (8), p.2551-2553

1978

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GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

British journal of haematology, 2016-10, Vol.175 (1), p.141-153

2016

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Inhibition of steroid 5α-reductase by unsaturated 3-carboxysteroids

Journal of medicinal chemistry, 1990-03, Vol.33 (3), p.943-950

1990

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Human immunodeficiency virus protease: A target for aids therapy

Drug development research, 1990, Vol.21 (1), p.1-17

1990

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Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2

The Journal of steroid biochemistry and molecular biology, 1994-02, Vol.48 (2), p.197-206

1994

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Steroidal a ring aryl carboxylic acids : a new class of steroid 5α-reductase inhibitors

Journal of medicinal chemistry, 1990-03, Vol.33 (3), p.937-942

1990

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Synergistic drug interactions of an HIV-1 protease inhibitor with AZT in different in vitro models of HIV-1 infection

Antiviral research, 1993-08, Vol.21 (4), p.327-342

1993

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Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

Journal of the American Chemical Society, 1981-06, Vol.103 (11), p.3221-3222

1981

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Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease

Biochemistry (Easton), 1992-10, Vol.31 (42), p.10153-10168

1992

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Inhibition of rat liver steroid 5α-reductase by 3-androstene-3-carboxylic acids : mechanism of enzyme-inhibitor interaction

Biochemistry (Easton), 1990-03, Vol.29 (11), p.2815-2824

1990

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Biochemical and endocrine properties of a mechanism-based inhibitor of aromatase

Endocrinology (Philadelphia), 1984-08, Vol.115 (2), p.776-785

1984

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gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

Journal of neurochemistry, 1977-11, Vol.29 (5), p.797-802

1977

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cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase

Journal of medicinal chemistry, 1988-07, Vol.31 (7), p.1355-1359

1988

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An Orally Bioavailable HIV-1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis

Biochemistry (Easton), 1994-10, Vol.33 (39), p.11671-11677

1994

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Purification and properties of the catalytic domain of human 3-hydroxy-3-methylglutaryl-CoA reductase expressed in Escherichia coli

Archives of biochemistry and biophysics, 1988-11, Vol.267 (1), p.110-118

1988

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Time-dependent inhibition of aromatase in trophoblastic tumor cells in tissue culture

Journal of steroid biochemistry, 1984-06, Vol.20 (6), p.1221-1226

1984

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Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Biochemistry (Easton), 1990-05, Vol.29 (17), p.4115-4120

1990

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Synthesis of a steroidal A ring aromatic sulfonic acid as an inhibitor of steroid 5α-reductase

Steroids, 1991, Vol.56 (1), p.4-7

1991

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Human Immunodeficiency Virus Protease Expressed in Escherichia coli Exhibits Autoprocessing and Specific Maturation of the Gag Precursor

Inhibition of Human Immunodeficiency Virus 1 Protease in vitro: Rational Design of Substrate Analogue Inhibitors

Human Immunodeficiency Virus 1 Protease Expressed in Escherichia coli Behaves as a Dimeric Aspartic Protease

Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, x-ray crystallography, and infected T-cell assays

Human immunodeficiency virus type 1 protease inhibitors irreversibly block infectivity of purified virions from chronically infected cells

The impact of genomics on medicinal chemistry

Peptide substrates and inhibitors of the HIV-1 protease

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half‐life in a murine model of sickle cell disease

Inhibition of steroid 5α-reductase by unsaturated 3-carboxysteroids

Human immunodeficiency virus protease: A target for aids therapy

Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5α-reductase isoform 2

Steroidal a ring aryl carboxylic acids : a new class of steroid 5α-reductase inhibitors

Synergistic drug interactions of an HIV-1 protease inhibitor with AZT in different in vitro models of HIV-1 infection

Substrate-induced inactivation of aromatase by allenic and acetylenic steroids

Proteolysis of an active site peptide of lactate dehydrogenase by human immunodeficiency virus type 1 protease

Inhibition of rat liver steroid 5α-reductase by 3-androstene-3-carboxylic acids : mechanism of enzyme-inhibitor interaction

Biochemical and endocrine properties of a mechanism-based inhibitor of aromatase

gamma-Vinyl GABA (4-amino-hex-5-enoic acid), a new selective irreversible inhibitor of GABA-T: effects on brain GABA metabolism in mice

cis-4-Carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one, a potent inhibitor of mammalian dihydroorotase

An Orally Bioavailable HIV-1 Protease Inhibitor Containing an Imidazole-Derived Peptide Bond Replacement: Crystallographic and Pharmacokinetic Analysis

Purification and properties of the catalytic domain of human 3-hydroxy-3-methylglutaryl-CoA reductase expressed in Escherichia coli

Time-dependent inhibition of aromatase in trophoblastic tumor cells in tissue culture

Slow binding inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Synthesis of a steroidal A ring aromatic sulfonic acid as an inhibitor of steroid 5α-reductase

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