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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

Chemical reviews, 2014-07, Vol.114 (13), p.6844-6879

2014

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Intrinsically disordered proteins are potential drug targets

Current opinion in chemical biology, 2010-08, Vol.14 (4), p.481-488

Metallo, Steven J

2010

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Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Cancer research (Chicago, Ill.), 2021-04, Vol.81 (7), p.1627-1632

2021

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Improved low molecular weight Myc-Max inhibitors

Molecular cancer therapeutics, 2007-09, Vol.6 (9), p.2399-2408

2007

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Portability of a Small-Molecule Binding Site between Disordered Proteins

Biomolecules (Basel, Switzerland), 2022-12, Vol.12 (12), p.1887

2022

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Oriented Protein Adsorption to Gold Nanoparticles through a Genetically Encodable Binding Motif

Langmuir, 2010-12, Vol.26 (24), p.18945-18950

2010

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Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1

Oncotarget, 2012-02, Vol.3 (2), p.172-182

2012

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Prototyping of Microfluidic Devices in Poly(dimethylsiloxane) Using Solid-Object Printing

Analytical chemistry (Washington), 2002-04, Vol.74 (7), p.1537-1545

2002

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Portability of Small Molecule Binding Sites in Intrinsically Disordered Proteins

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans

Journal of biomolecular screening, 2014-02, Vol.19 (2), p.270-277

2014

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Small-molecule perturbation of competing interactions between c-Myc and Max

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (3), p.807-810

2009

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Arrays of Self-Assembled Monolayers for Studying Inhibition of Bacterial Adhesion

Analytical chemistry (Washington), 2002-04, Vol.74 (8), p.1805-1810

2002

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Synthesis of Free-Standing Quasi-Two-Dimensional Polymers

Langmuir, 2003-03, Vol.19 (6), p.2466-2472

2003

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Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

Journal of medicinal chemistry, 2009-03, Vol.52 (5), p.1247-1250

2009

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Characterization of the Binding of Small Molecules to Intrinsically Disordered Proteins

Methods in enzymology, 2018, Vol.611, p.677-702

2018

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Using Bifunctional Polymers Presenting Vancomycin and Fluorescein Groups To Direct Anti-Fluorescein Antibodies to Self-Assembled Monolayers Presenting d-Alanine-d-Alanine Groups

Journal of the American Chemical Society, 2003-04, Vol.125 (15), p.4534-4540

2003

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Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm

Journal of molecular biology, 2018-08, Vol.430 (16), p.2321-2341

2018

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Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide

Biomaterials, 2006-07, Vol.27 (19), p.3663-3674

2006

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Fabrication of a Configurable, Single-Use Microfluidic Device

Analytical chemistry (Washington), 2001-12, Vol.73 (23), p.5645-5650

2001

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DNA Specificity Enhanced by Sequential Binding of Protein Monomers

Proceedings of the National Academy of Sciences - PNAS, 1999-10, Vol.96 (21), p.11735-11739

1999

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Interaction of the Intrinsically Disordered c-Myc Oncoprotein with Racemic and Enantiopure Small Molecules

Biophysical journal, 2015-01, Vol.108 (2), p.389a-389a

2015

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Enantiospecific Recognition of the Intrinsically Disordered C-Myc Oncoprotein by Small Molecules

Biophysical journal, 2014-01, Vol.106 (2), p.687a-687a

2014

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Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Chemistry & biology, 2008-11, Vol.15 (11), p.1149-1155

2008

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Primary Sequence Controls the Specificity and Affinity of a Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

Biophysical journal, 2015-01, Vol.108 (2), p.389a-389a

2015

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Hydrophobic and Hydrophilic Residues are Important for Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

Biophysical journal, 2013-01, Vol.104 (2), p.52a-53a

2013

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Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases

Intrinsically disordered proteins are potential drug targets

Drugging the "Undruggable" MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Improved low molecular weight Myc-Max inhibitors

Portability of a Small-Molecule Binding Site between Disordered Proteins

Oriented Protein Adsorption to Gold Nanoparticles through a Genetically Encodable Binding Motif

Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1

Prototyping of Microfluidic Devices in Poly(dimethylsiloxane) Using Solid-Object Printing

Portability of Small Molecule Binding Sites in Intrinsically Disordered Proteins

A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans

Small-molecule perturbation of competing interactions between c-Myc and Max

Arrays of Self-Assembled Monolayers for Studying Inhibition of Bacterial Adhesion

Synthesis of Free-Standing Quasi-Two-Dimensional Polymers

Discovery of Novel Myc−Max Heterodimer Disruptors with a Three-Dimensional Pharmacophore Model

Characterization of the Binding of Small Molecules to Intrinsically Disordered Proteins

Using Bifunctional Polymers Presenting Vancomycin and Fluorescein Groups To Direct Anti-Fluorescein Antibodies to Self-Assembled Monolayers Presenting d-Alanine-d-Alanine Groups

Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm

Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide

Fabrication of a Configurable, Single-Use Microfluidic Device

DNA Specificity Enhanced by Sequential Binding of Protein Monomers

Interaction of the Intrinsically Disordered c-Myc Oncoprotein with Racemic and Enantiopure Small Molecules

Enantiospecific Recognition of the Intrinsically Disordered C-Myc Oncoprotein by Small Molecules

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

Primary Sequence Controls the Specificity and Affinity of a Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

Hydrophobic and Hydrophilic Residues are Important for Small Molecule Binding to the Intrinsically Disordered Protein c-Myc

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