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Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA

Proceedings of the National Academy of Sciences - PNAS, 2024-07, Vol.121 (29)

2024

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Blocking the dimerization of polyglutamine-expanded androgen receptor protects cells from DHT-induced toxicity by increasing AR turnover

The Journal of biological chemistry, 2024-05, Vol.300 (5), p.107246, Article 107246

2024

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Molecular Mechanisms and Therapeutics for SBMA/Kennedy’s Disease

Neurotherapeutics, 2019-10, Vol.16 (4), p.928-947

2019

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The role of ubiquitination in spinal and bulbar muscular atrophy

Frontiers in molecular neuroscience, 2022-10, Vol.15, p.1020143

2022

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Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy

Scientific reports, 2019-01, Vol.9 (1), p.119, Article 119

2019

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A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila

Journal of neuroscience research, 2024-01, Vol.102 (1), p.e25278-n/a

2024

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Differentiating PC12 cells to evaluate neurite densities through live-cell imaging

STAR protocols, 2023-03, Vol.4 (1), p.101993-101993, Article 101993

2023

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Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

Nature chemical biology, 2013-02, Vol.9 (2), p.112-118

2013

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SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA

The Journal of neuroscience, 2011-11, Vol.31 (48), p.17425-17436

2011

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Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy

Acta neuropathologica communications, 2022-07, Vol.10 (1), p.97-22, Article 97

2022

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Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA

Cell reports (Cambridge), 2015-12, Vol.13 (10), p.2312-2323

2015

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Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy

Human molecular genetics, 2014-03, Vol.23 (5), p.1376-1386

2014

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Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease

The Journal of clinical investigation, 2015-02, Vol.125 (2), p.831-845

2015

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Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy

Brain research, 2015-12, Vol.1628 (Pt B), p.254-264

2015

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Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy

The Journal of clinical investigation, 2021-01, Vol.131 (1), p.1-18

2021

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Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

Human molecular genetics, 2009-06, Vol.18 (11), p.1937-1950

2009

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Attacking the flank: targeting new pathways in SBMA

Nature medicine, 2012-10, Vol.18 (10), p.1461-1463

Merry, Diane E

2012

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Fluorescence Imaging of Huntingtin mRNA Knockdown

Bioconjugate chemistry, 2018-04, Vol.29 (4), p.1276-1282

2018

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Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis

The Journal of biological chemistry, 2015-05, Vol.290 (20), p.12572-12584

2015

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N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

PLoS genetics, 2016-05, Vol.12 (5), p.e1006083-e1006083

2016

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Soluble Androgen Receptor Oligomers Underlie Pathology in a Mouse Model of Spinobulbar Muscular Atrophy

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3157-3164

2007

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An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy

The Journal of biological chemistry, 2010-11, Vol.285 (46), p.35567-35577

2010

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Castration Restores Function and Neurofilament Alterations of Aged Symptomatic Males in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy

The Journal of neuroscience, 2004-05, Vol.24 (20), p.4778-4786

2004

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Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

iScience, 2023-08, Vol.26 (8), p.107375-107375, Article 107375

2023

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ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

Nature medicine, 2007-03, Vol.13 (3), p.348-353

2007

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Mutant androgen receptor induces neurite loss and senescence independently of ARE binding in a neuronal model of SBMA

Blocking the dimerization of polyglutamine-expanded androgen receptor protects cells from DHT-induced toxicity by increasing AR turnover

Molecular Mechanisms and Therapeutics for SBMA/Kennedy’s Disease

The role of ubiquitination in spinal and bulbar muscular atrophy

Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy

A phenotypically robust model of spinal and bulbar muscular atrophy in Drosophila

Differentiating PC12 cells to evaluate neurite densities through live-cell imaging

Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation

SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA

Neuromuscular junction pathology is correlated with differential motor unit vulnerability in spinal and bulbar muscular atrophy

Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA

Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy

Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease

Identification of novel polyglutamine-expanded aggregation species in spinal and bulbar muscular atrophy

Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy

Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy

Attacking the flank: targeting new pathways in SBMA

Fluorescence Imaging of Huntingtin mRNA Knockdown

Proteasome-mediated Proteolysis of the Polyglutamine-expanded Androgen Receptor Is a Late Event in Spinal and Bulbar Muscular Atrophy (SBMA) Pathogenesis

N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy

Soluble Androgen Receptor Oligomers Underlie Pathology in a Mouse Model of Spinobulbar Muscular Atrophy

An Interdomain Interaction of the Androgen Receptor Is Required for Its Aggregation and Toxicity in Spinal and Bulbar Muscular Atrophy

Castration Restores Function and Neurofilament Alterations of Aged Symptomatic Males in a Transgenic Mouse Model of Spinal and Bulbar Muscular Atrophy

Increased SIRT3 combined with PARP inhibition rescues motor function of SBMA mice

ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor

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