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Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di- N -Oxide Derivatives

Molecules (Basel, Switzerland), 2019-06, Vol.24 (13), p.2348

2019

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Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

PLoS neglected tropical diseases, 2016-07, Vol.10 (7), p.e0004834-e0004834

2016

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Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity

Veterinary sciences, 2018-08, Vol.5 (3), p.74

2018

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Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

Frontiers in molecular biosciences, 2018-04, Vol.5, p.40-40

2018

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Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and structure–activity relationships

Bioorganic & medicinal chemistry, 2007-04, Vol.15 (7), p.2768-2781

2007

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Neuroprotective effects of novel nitrones: In vitro and in silico studies

European journal of pharmacology, 2020-03, Vol.871, p.172926-172926, Article 172926

2020

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Flavonoid‐Quinoxaline Hybrid Compounds as Cathepsin Inhibitors Against Fascioliasis

ChemMedChem, 2024-08, p.e202400305

2024

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Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D‐Aromatic‐Boron‐Rich‐Cluster into the 4‐Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment

Chemistry : a European journal, 2018-03, Vol.24 (13), p.3122-3126

2018

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Susceptibility and resistance to Echinococcus granulosus infection: Associations between mouse strains and early peritoneal immune responses

Immunobiology (1979), 2016-03, Vol.221 (3), p.418-426

2016

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Nitrones as Potential Therapeutic Agents Against Neurodegenerative Diseases

Free radical biology & medicine, 2017-11, Vol.112, p.21

2017

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4 - Nitrones as Potential Therapeutic Agents Against Neurodegenerative Diseases

Free radical biology & medicine, 2017-11, Vol.112, p.21-21

2017

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Insight into the mechanism of action and selectivity of caspase-3 reversible inhibitors through in silico studies

Journal of molecular structure, 2017-11, Vol.1147, p.558-568

2017

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Molecular docking and molecular dynamics simulation studies of Trypanosoma cruzi triosephosphate isomerase inhibitors. Insights into the inhibition mechanism and selectivity

Journal of molecular graphics & modelling, 2015-05, Vol.58, p.40-49

2015

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Cover Feature: Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D‐Aromatic‐Boron‐Rich‐Cluster into the 4‐Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment (Chem. Eur. J. 13/2018)

Chemistry : a European journal, 2018-03, Vol.24 (13), p.3071-3071

2018

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Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseases

Dalton transactions : an international journal of inorganic chemistry, 2015-08, Vol.44 (32), p.14453-14464

2015

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Expanding the family of heteroleptic oxidovanadium(IV) compounds with salicylaldehyde semicarbazones and polypyridyl ligands showing anti-Trypanosoma cruzi activity

Journal of inorganic biochemistry, 2015-06, Vol.147, p.116-125

2015

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Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties

European journal of medicinal chemistry, 2017-08, Vol.136, p.223-234

2017

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Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: Ligand docking, molecular dynamics validation, and insights on their binding modes

Journal of molecular graphics & modelling, 2014-03, Vol.48, p.47-59

2014

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Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

Bioorganic & medicinal chemistry, 2011-11, Vol.19 (22), p.6818-6826

2011

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In search of patterns over physicochemical properties and pharmacological activities for a set of [MCl 2(thiosemicarbazone)] complexes (M = Pt/Pd): Support for multiple mechanisms of antichagasic action excluding DNA-bonding in vivo?

European journal of medicinal chemistry, 2011-07, Vol.46 (7), p.2639-2651

2011

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One pot synthesis of benzyltriphenylphosphonium acetates from the corresponding activated benzylic alcohols

ARKIVOC, 2006-06, Vol.2006 (11), p.128-136

2006

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Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies

European journal of medicinal chemistry, 2009-11, Vol.44 (11), p.4426-4433

2009

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Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies

European journal of medicinal chemistry, 2009-12, Vol.44 (12), p.5055-5065

2009

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Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseasesElectronic supplementary information (ESI) available: KS HOMO and LUMO calculated features for both [M(mpo)(dppf)]+ complexes (Fig. S1). Table of calculated Wiberg bond indices (WBI) for the main bonding interactions in the [M(mpo)(dppf)]+ structures (Table S1). Tables of calculated NPA atomic charges for the mpo moiety in the [M(mpo)(dppf)]+ species and in the free ligand, and for the me

2015-08

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Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di- N -Oxide Derivatives

Identification of Chalcones as Fasciola hepatica Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach

Novel and Selective Rhipicephalus microplus Triosephosphate Isomerase Inhibitors with Acaricidal Activity

Substrate Specificity of Cysteine Proteases Beyond the S2 Pocket: Mutagenesis and Molecular Dynamics Investigation of Fasciola hepatica Cathepsins L

Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and structure–activity relationships

Neuroprotective effects of novel nitrones: In vitro and in silico studies

Flavonoid‐Quinoxaline Hybrid Compounds as Cathepsin Inhibitors Against Fascioliasis

Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D‐Aromatic‐Boron‐Rich‐Cluster into the 4‐Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment

Susceptibility and resistance to Echinococcus granulosus infection: Associations between mouse strains and early peritoneal immune responses

Nitrones as Potential Therapeutic Agents Against Neurodegenerative Diseases

4 - Nitrones as Potential Therapeutic Agents Against Neurodegenerative Diseases

Insight into the mechanism of action and selectivity of caspase-3 reversible inhibitors through in silico studies

Molecular docking and molecular dynamics simulation studies of Trypanosoma cruzi triosephosphate isomerase inhibitors. Insights into the inhibition mechanism and selectivity

Cover Feature: Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D‐Aromatic‐Boron‐Rich‐Cluster into the 4‐Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment (Chem. Eur. J. 13/2018)

Aromatic amine N-oxide organometallic compounds: searching for prospective agents against infectious diseases

Expanding the family of heteroleptic oxidovanadium(IV) compounds with salicylaldehyde semicarbazones and polypyridyl ligands showing anti-Trypanosoma cruzi activity

Novel Imidazo[4,5-c][1,2,6]thiadiazine 2,2-dioxides as antiproliferative trypanosoma cruzi drugs: Computational screening from neural network, synthesis and in vivo biological properties

Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: Ligand docking, molecular dynamics validation, and insights on their binding modes

Potent and Selective Inhibitors of Trypanosoma cruzi Triosephosphate Isomerase with Concomitant Inhibition of Cruzipain: Inhibition of Parasite Growth through Multitarget Activity

Thiosemicarbazones derived from 1-indanones as new anti-Trypanosoma cruzi agents

In search of patterns over physicochemical properties and pharmacological activities for a set of [MCl 2(thiosemicarbazone)] complexes (M = Pt/Pd): Support for multiple mechanisms of antichagasic action excluding DNA-bonding in vivo?

One pot synthesis of benzyltriphenylphosphonium acetates from the corresponding activated benzylic alcohols

Second generation of 2H-benzimidazole 1,3-dioxide derivatives as anti-trypanosomatid agents: Synthesis, biological evaluation, and mode of action studies

Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies

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