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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

The Journal of biological chemistry, 2011-01, Vol.286 (2), p.987-996

2011

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Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

The Journal of biological chemistry, 2007-03, Vol.282 (13), p.9372-9382

2007

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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Angewandte Chemie International Edition, 2007-01, Vol.46 (33), p.6278-6283

2007

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Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

Bioorganic & medicinal chemistry, 2010-04, Vol.18 (7), p.2586-2597

2010

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Antitumour and antimalarial activity of artemisinin-acridine hybrids

Bioorganic & medicinal chemistry letters, 2009-04, Vol.19 (7), p.2033-2037

2009

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Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

Bioorganic & medicinal chemistry, 2009-02, Vol.17 (3), p.1325-1338

2009

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Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Angewandte Chemie (International ed.), 2007-08, Vol.46 (33), p.6278-6283

2007

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The elucidation of the mechanisms of bleomycin-induced cytotoxicity in alveolar type II cells in vitro

Toxicology (Amsterdam), 2011, Vol.290 (2), p.140-140

2011

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Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin

Journal of medicinal chemistry, 2004-02, Vol.47 (5), p.1290-1298

2004

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The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations

Expert opinion on drug metabolism & toxicology, 2011-04, Vol.7 (4), p.427-439

2011

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Assessing the cytotoxic profile of novel endoperoxide derivatives

Toxicology (Amsterdam), 2011, Vol.290 (2), p.138-138

2011

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Characterisation of bleomycin-induced cytotoxicity in mammalian alveolar type II cells

Toxicology (Amsterdam), 2010, Vol.278 (3), p.362-362

2010

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Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

Molecular medicine (Cambridge, Mass.), 2012-07, Vol.18 (7), p.1045-1055

2012

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Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis

Toxicology and applied pharmacology, 2009-09, Vol.239 (3), p.297-305

2009

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Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols

Organic & biomolecular chemistry, 2010-01, Vol.8 (9), p.2068-2077

2010

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The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials

Toxicology (Amsterdam), 2010, Vol.278 (3), p.358-359

2010

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A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Nature communications, 2017-05, Vol.8 (1), p.15159-10, Article 15159

2017

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The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials

Current opinion in drug discovery & development, 2009-01, Vol.12 (1), p.125

Mercer, Amy E

2009

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Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Angewandte Chemie, 2007-08, Vol.119 (33), p.6394-6399

2007

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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Angewandte Chemie, 2007-08, Vol.119 (33), p.6394-6399

2007

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Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin

Journal of medicinal chemistry, 2004-02, Vol.47 (5), p.1290-1298

2004

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Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Angewandte Chemie, 2007-08, Vol.119 (33), p.6394-6399

2007

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Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study

International journal of molecular sciences, 2012-10, Vol.13 (11), p.13781-13803

2012

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Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

Nature (London), 2011-02, Vol.470 (7335), p.492-497

2011

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New models of health and social care for people in later life: mapping of innovation in services in two regions of the United Kingdom using a mixed method approach

BMC health services research, 2024-07, Vol.24 (1), p.812-13, Article 812

2024

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The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

Evidence for the Involvement of Carbon-centered Radicals in the Induction of Apoptotic Cell Death by Artemisinin Compounds

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

Antitumour and antimalarial activity of artemisinin-acridine hybrids

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

The elucidation of the mechanisms of bleomycin-induced cytotoxicity in alveolar type II cells in vitro

Antimalarial and Antitumor Evaluation of Novel C-10 Non-Acetal Dimers of 10β-(2-Hydroxyethyl)deoxoartemisinin

The pharmacokinetic evaluation of artemisinin drugs for the treatment of malaria in paediatric populations

Assessing the cytotoxic profile of novel endoperoxide derivatives

Characterisation of bleomycin-induced cytotoxicity in mammalian alveolar type II cells

Examination of the cytotoxic and embryotoxic potential and underlying mechanisms of next-generation synthetic trioxolane and tetraoxane antimalarials

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis

Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols

The chemical and molecular basis of mammalian cell susceptibility to cell death induced by the artemisinin antimalarials

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

The role of bioactivation in the pharmacology and toxicology of the artemisinin-based antimalarials

Evidence for a Common Non-Heme Chelatable-Iron-Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Antimalarial and antitumor evaluation of novel C-10 non-acetal dimers of 10beta-(2-hydroxyethyl)deoxoartemisinin

Evidence for a Common Non‐Heme Chelatable‐Iron‐Dependent Activation Mechanism for Semisynthetic and Synthetic Endoperoxide Antimalarial Drugs

Impairment of coronary arteriolar endothelium-dependent dilation after multi-walled carbon nanotube inhalation: a time-course study

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor

New models of health and social care for people in later life: mapping of innovation in services in two regions of the United Kingdom using a mixed method approach

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