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Exciting new tools for studying TREM2 in dementia

Structure (London), 2021-11, Vol.29 (11), p.1215-1216

2021

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Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence

BMC chemistry, 2021-09, Vol.15 (1), p.1-13, Article 51

2021

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PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

The EMBO journal, 2021-09, Vol.40 (17), p.e105603-n/a

2021

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Glycosylation increases active site rigidity leading to improved enzyme stability and turnover

The FEBS journal, 2023-08, Vol.290 (15), p.3812-3827

2023

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Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5

Immunology, 2020-10, Vol.161 (2), p.103-113

2020

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Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

Nucleic acids research, 2015-10, Vol.43 (19), p.9133

2015

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Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

NPJ biofilms and microbiomes, 2018-06, Vol.4 (1), p.13-10, Article 13

2018

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A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease

Molecular pharmaceutics, 2016-03, Vol.13 (3), p.863-872

2016

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Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort

Translational psychiatry, 2020-09, Vol.10 (1), p.309-309, Article 309

2020

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Benefits and Challenges of Rare Genetic Variation in Alzheimer’s Disease

Current genetic medicine reports, 2019-03, Vol.7 (1), p.53-62

2019

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Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer

Translational research : the journal of laboratory and clinical medicine, 2014, Vol.163 (1), p.19-26

2014

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MutAIT: an online genetic toxicology data portal and analysis tools

Mutagenesis, 2016-05, Vol.31 (3), p.323-328

2016

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P1‐245: MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER'S DISEASE

Alzheimer's & dementia, 2018-07, Vol.14 (7S_Part_7), p.P372-P372

2018

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MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER’S DISEASE

Alzheimer's & dementia, 2018-07, Vol.14 (7), p.P372-P372

2018

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ENHANCED FUNCTION OF PLCG2 VARIANT P522R IN MACROPHAGES AND MICROGLIA IS ASSOCIATED WITH PROTECTION FROM ALZHEIMER’S DISEASE

Alzheimer's & dementia, 2019-07, Vol.15 (7), p.P1641-P1641

2019

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MOLECULAR DYNAMIC MODELLING OF A NOVEL PLCG2 VARIANT REVEALS KEY PROTEIN STRUCTURAL DIFFERENCES

Alzheimer's & dementia, 2017-07, Vol.13 (7), p.P1489-P1490

2017

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The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P 2 levels and altering cell function in in vitro and in vivo assays: Developing topics

Alzheimer's & dementia, 2020-12, Vol.16 (S3)

2020

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The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P2 levels and altering cell function in in vitro and in vivo assays

Alzheimer's & dementia, 2020-12, Vol.16, p.n/a

2020

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O5‐10‐01: ENHANCED FUNCTION OF PLCG2 VARIANT P522R IN MACROPHAGES AND MICROGLIA IS ASSOCIATED WITH PROTECTION FROM ALZHEIMER'S DISEASE

Alzheimer's & dementia, 2019-07, Vol.15 (7S_Part_31), p.P1641-P1641

2019

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P2‐112: NEXT GENERATION EXOME SEQUENCING IN A LARGE SAMPLE OF ALZHEIMER'S PATIENTS

Alzheimer's & dementia, 2018-07, Vol.14 (7S_Part_13), p.P712-P712

2018

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NEXT GENERATION EXOME SEQUENCING IN A LARGE SAMPLE OF ALZHEIMER’S PATIENTS

Alzheimer's & dementia, 2018-07, Vol.14 (7), p.P712-P712

2018

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Cutaneous melanoma

The Lancet (British edition), 2023-08, Vol.402 (10400), p.485-502

2023

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BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

Clinical cancer research, 2014-04, Vol.20 (7), p.1965-1977

2014

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Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma

Clinical cancer research, 2017-09, Vol.23 (17), p.5024-5033

2017

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PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials

Pigment cell and melanoma research, 2015-05, Vol.28 (3), p.245-253

2015

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Exciting new tools for studying TREM2 in dementia

Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence

PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522

Glycosylation increases active site rigidity leading to improved enzyme stability and turnover

Characterizing the original anti‐C5 function‐blocking antibody, BB5.1, for species specificity, mode of action and interactions with C5

Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability

Targeted disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate oligosaccharides

A New Class of Safe Oligosaccharide Polymer Therapy To Modify the Mucus Barrier of Chronic Respiratory Disease

Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort

Benefits and Challenges of Rare Genetic Variation in Alzheimer’s Disease

Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer

MutAIT: an online genetic toxicology data portal and analysis tools

P1‐245: MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER'S DISEASE

MOLECULAR DYNAMIC MODELLING OF TWO TREM2 MUTATIONS REVEAL KEY STRUCTURAL SIMILARITIES AND PROBABLE FUNCTIONAL IMPACT IN ALZHEIMER’S DISEASE

ENHANCED FUNCTION OF PLCG2 VARIANT P522R IN MACROPHAGES AND MICROGLIA IS ASSOCIATED WITH PROTECTION FROM ALZHEIMER’S DISEASE

MOLECULAR DYNAMIC MODELLING OF A NOVEL PLCG2 VARIANT REVEALS KEY PROTEIN STRUCTURAL DIFFERENCES

The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P 2 levels and altering cell function in in vitro and in vivo assays: Developing topics

The Alzheimer’s disease protective R522 variant of PLCg2, consistently enhances PLCγ2 activation, depleting PI(4,5)P2 levels and altering cell function in in vitro and in vivo assays

O5‐10‐01: ENHANCED FUNCTION OF PLCG2 VARIANT P522R IN MACROPHAGES AND MICROGLIA IS ASSOCIATED WITH PROTECTION FROM ALZHEIMER'S DISEASE

P2‐112: NEXT GENERATION EXOME SEQUENCING IN A LARGE SAMPLE OF ALZHEIMER'S PATIENTS

NEXT GENERATION EXOME SEQUENCING IN A LARGE SAMPLE OF ALZHEIMER’S PATIENTS

Cutaneous melanoma

BRAF Inhibitor Resistance Mechanisms in Metastatic Melanoma: Spectrum and Clinical Impact

Dynamic Changes in PD-L1 Expression and Immune Infiltrates Early During Treatment Predict Response to PD-1 Blockade in Melanoma

PD-L1 expression in melanoma shows marked heterogeneity within and between patients: implications for anti-PD-1/PD-L1 clinical trials

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