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Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors

Bioorganic & medicinal chemistry, 2020-10, Vol.28 (19), p.115681-115681, Article 115681

2020

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ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Journal of molecular biology, 2004-04, Vol.279 (17), p.17996-18007

2004

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Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

Cancer research (Chicago, Ill.), 2010-06, Vol.70 (11), p.4318-4326

2010

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Automated High-Throughput Flow Cytometry for High-Content Screening in Antibody Development

SLAS discovery, 2018-08, Vol.23 (7), p.656-666

2018

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Role of the [4Fe-4S] Cluster in Reductive Activation of the Cobalt Center of the Corrinoid Iron−Sulfur Protein from Clostridium thermoaceticum during Acetate Biosynthesis

Biochemistry (Easton), 1998-04, Vol.37 (16), p.5689-5698

1998

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Mechanism of the Clostridium thermoaceticum Pyruvate:Ferredoxin Oxidoreductase: Evidence for the Common Catalytic Intermediacy of the Hydroxyethylthiamine Pyropyrosphate Radical

Biochemistry (Easton), 1997-07, Vol.36 (28), p.8484-8494

1997

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Machine Learning Methods Using Artificial Intelligence Deployed on Electronic Health Record Data for Identification and Referral of At-Risk Patients From Primary Care Physicians to Eye Care Specialists: Retrospective, Case-Controlled Study

JMIR AI, 2024-03, Vol.3, p.e48295

2024

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Stereochemical Course and Steady State Mechanism of the Reaction Catalyzed by the GDP-fucose Synthetase from Escherichia coli

The Journal of biological chemistry, 1999-09, Vol.274 (38), p.26743-26750

1999

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The Role of an Iron-Sulfur Cluster in an Enzymatic Methylation Reaction

The Journal of biological chemistry, 1999-04, Vol.274 (17), p.11513-11518

1999

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The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

Blood, 2016-12, Vol.128 (22), p.3296-3296

2016

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TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Cancer research communications, 2022-06, Vol.2 (6), p.489-502

2022

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Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4795-4799

2010

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Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG

Bioorganic & medicinal chemistry letters, 2016-02, Vol.26 (4), p.1156-1160

2016

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Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors

Journal of medicinal chemistry, 2011-03, Vol.54 (6), p.1836-1846

2011

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Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC

Journal of clinical oncology, 2013-05, Vol.31 (15_suppl), p.e13529-e13529

2013

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Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of melanoma and CRC

Molecular cancer therapeutics, 2013-11, Vol.12 (11_Supplement), p.C146-C146

2013

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The role of an iron-sulfur cluster in an enzymatic methylation reaction. Methylation of CO dehydrogenase/acetyl-CoA synthase by the methylated corrinoid iron-sulfur protein

The Journal of biological chemistry, 1999-04, Vol.274 (17), p.11513-11518

1999

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Discovery and optimization of pyrazoline compounds as B-Raf inhibitors

Bioorganic & medicinal chemistry letters, 2010-08, Vol.20 (16), p.4800-4804

2010

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Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose

Structure (London), 2000-02, Vol.8 (2), p.123-135

2000

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Abstract A70: A genome-wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib

Molecular cancer therapeutics, 2009-12, Vol.8 (12_Supplement), p.A70-A70

2009

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Unleashing Hydrogenase Activity in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase and Pyruvate:Ferredoxin Oxidoreductase

Biochemistry (Easton), 1996-12, Vol.35 (49), p.15814-15821

1996

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Evidence That Carbon Monoxide Is an Obligatory Intermediate in Anaerobic Acetyl-CoA Synthesis

Biochemistry (Easton), 1996-09, Vol.35 (37), p.12119-12125

1996

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ENDOR Studies of Pyruvate:Ferredoxin Oxidoreductase Reaction Intermediates

Journal of the American Chemical Society, 1999-04, Vol.121 (15), p.3724-3729

1999

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Mechanism of pyruvate ferredoxin oxidoreductase and role of the (4Fe-4S) cluster of the corrinoid iron sulfur protein in acetyl COA synthesis by the Wood Ljungdahl pathway

Menon, Saurabh Prabhakar

1997

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A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment

Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Genome-Wide siRNA Screen for Modulators of Cell Death Induced by Proteasome Inhibitor Bortezomib

Automated High-Throughput Flow Cytometry for High-Content Screening in Antibody Development

Role of the [4Fe-4S] Cluster in Reductive Activation of the Cobalt Center of the Corrinoid Iron−Sulfur Protein from Clostridium thermoaceticum during Acetate Biosynthesis

Mechanism of the Clostridium thermoaceticum Pyruvate:Ferredoxin Oxidoreductase: Evidence for the Common Catalytic Intermediacy of the Hydroxyethylthiamine Pyropyrosphate Radical

Machine Learning Methods Using Artificial Intelligence Deployed on Electronic Health Record Data for Identification and Referral of At-Risk Patients From Primary Care Physicians to Eye Care Specialists: Retrospective, Case-Controlled Study

Stereochemical Course and Steady State Mechanism of the Reaction Catalyzed by the GDP-fucose Synthetase from Escherichia coli

The Role of an Iron-Sulfur Cluster in an Enzymatic Methylation Reaction

The Anti-Tumor Effect of the Ubiquitin-Activating Enzyme (UAE) Inhibitor TAK-243 on Pre-Clinical Models of Multiple Myeloma

TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

Discovery and optimization of N-acyl and N-aroylpyrazolines as B-Raf kinase inhibitors

Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG

Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors

Use of combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 on the growth of BRAF-mutant and RAS-mutant preclinical models of melanoma and CRC

Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480 and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models of melanoma and CRC

The role of an iron-sulfur cluster in an enzymatic methylation reaction. Methylation of CO dehydrogenase/acetyl-CoA synthase by the methylated corrinoid iron-sulfur protein

Discovery and optimization of pyrazoline compounds as B-Raf inhibitors

Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose

Abstract A70: A genome-wide siRNA screen for modulators of cell death induced by the proteasome inhibitor bortezomib

Unleashing Hydrogenase Activity in Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase and Pyruvate:Ferredoxin Oxidoreductase

Evidence That Carbon Monoxide Is an Obligatory Intermediate in Anaerobic Acetyl-CoA Synthesis

ENDOR Studies of Pyruvate:Ferredoxin Oxidoreductase Reaction Intermediates

Mechanism of pyruvate ferredoxin oxidoreductase and role of the (4Fe-4S) cluster of the corrinoid iron sulfur protein in acetyl COA synthesis by the Wood Ljungdahl pathway

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