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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Medicinal research reviews, 2016-09, Vol.36 (5), p.924-963

2016

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Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10837-10858

2016

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CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Redox biology, 2019-09, Vol.26, p.101266-101266, Article 101266

2019

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An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Scientific reports, 2016-05, Vol.6 (1), p.26585-26585, Article 26585

2016

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Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

European journal of medicinal chemistry, 2020-12, Vol.207, p.112734, Article 112734

2020

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Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy

Theranostics, 2021, Vol.11 (5), p.2395-2409

2021

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Harmine targets inhibitor of DNA binding‐2 and activator protein‐1 to promote preosteoclast PDGF‐BB production

Journal of cellular and molecular medicine, 2021-06, Vol.25 (12), p.5525-5533

2021

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Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Journal of medicinal chemistry, 2015-08, Vol.58 (16), p.6410-6421

2015

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Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y

Advanced science, 2021-12, Vol.8 (24), p.e2100808-n/a

2021

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Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin-Induced Nephrotoxicity In Vivo and In Vitro

Kidney & blood pressure research, 2016-01, Vol.41 (6), p.911-918

2016

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Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

RSC advances, 2015, Vol.5 (105), p.85983-85987

2015

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Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4644-4654

2020

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Damage detection of truss bridge elements using an enhanced pseudo-local flexibility method

Journal of civil structural health monitoring, 2024-03, Vol.14 (3), p.615-634

2024

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Polar Recognition Group Study of Keap1-Nrf2 Protein–Protein Interaction Inhibitors

ACS medicinal chemistry letters, 2016-09, Vol.7 (9), p.835-840

2016

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New understanding of aconitine hydrolysis pathway: Isolation, identification and toxicity evaluation based on intermediate products

Arabian journal of chemistry, 2022-11, Vol.15 (11), p.104255, Article 104255

2022

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Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

Journal of medicinal chemistry, 2019-04, Vol.62 (8), p.3840-3856

2019

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Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

MedChemComm, 2014, Vol.5 (1), p.93-98

2014

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Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2736-2745

2014

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Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer’s Disease

Molecular neurobiology, 2022-12, Vol.59 (12), p.7323-7336

2022

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Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3

Autophagy, 2021-10, Vol.17 (10), p.2766-2782

2021

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Discovery of a Potent Kelch-Like ECH-Associated Protein 1‑Nuclear Factor Erythroid 2‑Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity

Journal of medicinal chemistry, 2019-07, Vol.62 (14), p.6796-6813

2019

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Targeting autophagy receptors OPTN and SQSTM1 as a novel therapeutic strategy for osteoporosis complicated with Alzheimer's disease

Chemico-biological interactions, 2023-05, Vol.377, p.110462-110462, Article 110462

2023

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Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency

European journal of medicinal chemistry, 2018-01, Vol.143, p.1578-1589

2018

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Recurrent de novo single point variant on the gene encoding Na+/K+ pump results in epilepsy

Progress in neurobiology, 2022-09, Vol.216, p.102310-102310, Article 102310

2022

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A strategy to identify and quantify closely related adulterant herbal materials by mass spectrometry-based partial least squares regression

Analytica chimica acta, 2017-07, Vol.977, p.28-35

2017

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The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update

Discovery and Development of Kelch-like ECH-Associated Protein 1. Nuclear Factor Erythroid 2‑Related Factor 2 (KEAP1:NRF2) Protein–Protein Interaction Inhibitors: Achievements, Challenges, and Future Directions

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Discovery of 2-oxy-2-phenylacetic acid substituted naphthalene sulfonamide derivatives as potent KEAP1-NRF2 protein-protein interaction inhibitors for inflammatory conditions

Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer's disease by enhancing autophagy

Harmine targets inhibitor of DNA binding‐2 and activator protein‐1 to promote preosteoclast PDGF‐BB production

Structure–Activity and Structure–Property Relationship and Exploratory in Vivo Evaluation of the Nanomolar Keap1–Nrf2 Protein–Protein Interaction Inhibitor

Neuronal Induction of Bone‐Fat Imbalance through Osteocyte Neuropeptide Y

Evaluation of KIM-1 and NGAL as Early Indicators for Assessment of Gentamycin-Induced Nephrotoxicity In Vivo and In Vitro

Binding thermodynamics and kinetics guided optimization of potent Keap1–Nrf2 peptide inhibitors

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Damage detection of truss bridge elements using an enhanced pseudo-local flexibility method

Polar Recognition Group Study of Keap1-Nrf2 Protein–Protein Interaction Inhibitors

New understanding of aconitine hydrolysis pathway: Isolation, identification and toxicity evaluation based on intermediate products

Nuclear Factor Erythroid 2‑Related Factor 2 (Nrf2) Inhibition: An Emerging Strategy in Cancer Therapy

Novel protein–protein interaction inhibitor of Nrf2–Keap1 discovered by structure-based virtual screening

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer’s Disease

Autophagy receptor OPTN (optineurin) regulates mesenchymal stem cell fate and bone-fat balance during aging by clearing FABP3

Discovery of a Potent Kelch-Like ECH-Associated Protein 1‑Nuclear Factor Erythroid 2‑Related Factor 2 (Keap1–Nrf2) Protein–Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity

Targeting autophagy receptors OPTN and SQSTM1 as a novel therapeutic strategy for osteoporosis complicated with Alzheimer's disease

Discovery of a head-to-tail cyclic peptide as the Keap1-Nrf2 protein-protein interaction inhibitor with high cell potency

Recurrent de novo single point variant on the gene encoding Na+/K+ pump results in epilepsy

A strategy to identify and quantify closely related adulterant herbal materials by mass spectrometry-based partial least squares regression

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