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Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma

Cancer research (Chicago, Ill.), 1999-08, Vol.59 (15), p.3671-3676

1999

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Prostate cancer and the androgen receptor: strategies for the development of novel therapeutics

Progress in drug research, 2000, Vol.55, p.213

Mendelsohn, L G

2000

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A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors

Cancer research (Chicago, Ill.), 1994-02, Vol.54 (4), p.1021-1026

1994

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Expression, purification, and characterization of active recombinant prostate-specific antigen in Pichia pastoris (yeast)

The Prostate, 2001-03, Vol.46 (4), p.298-306

2001

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Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors

Journal of medicinal chemistry, 1993-10, Vol.36 (20), p.2833-2841

1993

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3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Journal of medicinal chemistry, 1993-10, Vol.36 (20), p.2842-2850

1993

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Quinazolinone cholecystokinin-B receptor ligands

Journal of medicinal chemistry, 1991-04, Vol.34 (4), p.1505-1508

1991

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Synthesis and x-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands

Journal of medicinal chemistry, 1992-07, Vol.35 (14), p.2534-2542

1992

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Recombinant Human Insulin-Like Growth Factor II Expressed in Escherichia coli

Bio/technology (New York, N.Y. 1983), 1987-10, Vol.5 (10), p.1047-1051

1987

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Cell cycle effects of antifolate antimetabolites : implications for cytotoxicity and cytostasis

Cancer chemotherapy and pharmacology, 1997, Vol.39 (6), p.521-531

1997

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Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs

Molecular pharmacology, 1995-08, Vol.48 (2), p.326-333

1995

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Comparison of two penicillamine-containing enkephalins: Mu, not delta, activity produces analgesia

Neuropeptides (Edinburgh), 1986-08, Vol.8 (2), p.119-125

1986

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Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy

Advances in enzyme regulation, 1999-01, Vol.39 (1), p.313-327

1999

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Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

Clinical cancer research, 1996-07, Vol.2 (7), p.1135-1141

1996

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Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol

Investigational new drugs, 1996-01, Vol.14 (3), p.287-294

1996

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Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet

Cancer chemotherapy and pharmacology, 1997-12, Vol.41 (3), p.201-209

1997

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Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts

Biochemical pharmacology, 1996-11, Vol.52 (9), p.1477-1479

1996

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Expression, purification, and characterization of active recombinant prostate-specific antigen inPichia pastoris (yeast)

The Prostate, 2001-03, Vol.46 (4), p.298-306

2001

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The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3- D]pyrimidine based antifolates as antineoplastic and antiarthritic agents

Bioorganic & medicinal chemistry letters, 1999-01, Vol.9 (1), p.75-78

1999

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Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

Bioorganic & medicinal chemistry letters, 1996-02, Vol.6 (4), p.473-476

1996

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The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine

The Journal of pharmacology and experimental therapeutics, 1998-10, Vol.287 (1), p.315

1998

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Growth hormone receptors

Life Sciences, 1988, Vol.43 (1), p.1-5

Mendelsohn, Laurane G.

1988

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The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography

Brain research, 1988-04, Vol.445 (2), p.241-246

1988

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Phencyclidine receptors in rat brain cortex

Biochemical pharmacology, 1984-11, Vol.33 (22), p.3529-3535

1984

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Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

Advances in enzyme regulation, 1998-01, Vol.38 (1), p.135-152

1998

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Cell cycle modulation by a multitargeted antifolate, LY231514, increases the cytotoxicity and antitumor activity of gemcitabine in HT29 colon carcinoma

Prostate cancer and the androgen receptor: strategies for the development of novel therapeutics

A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors

Expression, purification, and characterization of active recombinant prostate-specific antigen in Pichia pastoris (yeast)

Structure-activity relationships of trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine antagonists for .mu.- and .kappa.-opioid receptors

3,4-Dimethyl-4-(3-hydroxyphenyl)piperidines: opioid antagonists with potent anorectant activity

Quinazolinone cholecystokinin-B receptor ligands

Synthesis and x-ray crystallographic analysis of quinazolinone cholecystokinin/gastrin receptor ligands

Recombinant Human Insulin-Like Growth Factor II Expressed in Escherichia coli

Cell cycle effects of antifolate antimetabolites : implications for cytotoxicity and cytostasis

Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs

Comparison of two penicillamine-containing enkephalins: Mu, not delta, activity produces analgesia

Enzymatic rationale and preclinical support for a potent protein kinase C beta inhibitor in cancer therapy

Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol

Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet

Dietary folate and folylpolyglutamate synthetase activity in normal and neoplastic murine tissues and human tumor xenografts

Expression, purification, and characterization of active recombinant prostate-specific antigen inPichia pastoris (yeast)

The synthesis and biological activity of a series of 2,4-diaminopyrido[2,3- D]pyrimidine based antifolates as antineoplastic and antiarthritic agents

Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure

The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine

Growth hormone receptors

The insulin-like growth factor-II (IGF-II) receptor of rat brain: regional distribution visualized by autoradiography

Phencyclidine receptors in rat brain cortex

Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA)

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