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RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

Human molecular genetics, 2019-11, Vol.28 (21), p.3552-3568

2019

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Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

Neurobiology of disease, 2018-03, Vol.111, p.26-35

2018

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LRRK2 and ubiquitination: implications for kinase inhibitor therapy

Biochemical journal, 2015-09, Vol.470 (3), p.e21-e24

Melrose, Heather L

2015

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Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Human molecular genetics, 2018-09, Vol.27 (18), p.3257-3271

2018

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Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Biochemical journal, 2013-07, Vol.453 (1), p.101-113

2013

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Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

Journal of comparative neurology (1911), 2014-08, Vol.522 (11), p.2465-2480

2014

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LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

Molecular neurodegeneration, 2012-05, Vol.7 (1), p.25-25, Article 25

2012

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ER stress response plays an important role in aggregation of α-synuclein

Molecular neurodegeneration, 2010-12, Vol.5 (1), p.56-56, Article 56

2010

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Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

Journal of neuroimmunology, 2016-03, Vol.292, p.1-8

2016

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A comparative study of Lrrk2 function in primary neuronal cultures

Parkinsonism & related disorders, 2010-12, Vol.16 (10), p.650-655

2010

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Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

The Journal of neuroscience, 2015-04, Vol.35 (14), p.5851-5859

2015

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LRRK2 contributes to monocyte dysregulation in Parkinson's disease

Acta neuropathologica communications, 2016-11, Vol.4 (1), p.123-123, Article 123

2016

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Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson’s Disease

Neuroscience, 2020-05, Vol.433, p.53-71

2020

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VPS35 Mutations in Parkinson Disease

American journal of human genetics, 2011-07, Vol.89 (1), p.162-167

2011

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Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

BMC neuroscience, 2016-11, Vol.17 (1), p.77-77, Article 77

2016

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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

Human molecular genetics, 2015-03, Vol.24 (5), p.1336-1349

2015

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Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

American journal of human genetics, 2011-09, Vol.89 (3), p.398-406

2011

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Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

Alzheimer's & dementia, 2021-03, Vol.17 (3), p.417-430

2021

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LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

Acta neuropathologica, 2013-12, Vol.126 (6), p.809-827

2013

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Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice

Neurobiology of learning and memory, 2017-07, Vol.142 (Pt B), p.182-189

2017

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Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

NPJ Parkinson's Disease, 2018-04, Vol.4 (1), p.13-5, Article 13

2018

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ER stress response plays an important role in aggregation of [alpha]-synuclein

Molecular neurodegeneration, 2010-12, Vol.5, p.56

2010

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Transgenic mice expressing human glucocerebrosidase variants: Utility for the study of Gaucher disease

Blood cells, molecules, & diseases, 2013-08, Vol.51 (2), p.109-115

2013

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Leucine-rich repeat kinase 1 : a paralog of LRRK2 and a candidate gene for Parkinson's disease

Neurogenetics, 2007-04, Vol.8 (2), p.95-102

2007

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Parkinson's disease : a rethink of rodent models

Experimental brain research, 2006-08, Vol.173 (2), p.196-204

2006

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RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons

LRRK2 and ubiquitination: implications for kinase inhibitor therapy

Proteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

ER stress response plays an important role in aggregation of α-synuclein

Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

A comparative study of Lrrk2 function in primary neuronal cultures

Neuronal LRP1 regulates glucose metabolism and insulin signaling in the brain

LRRK2 contributes to monocyte dysregulation in Parkinson's disease

Gait Deficits and Loss of Striatal Tyrosine Hydroxlase/Trk-B are Restored Following 7,8-Dihydroxyflavone Treatment in a Progressive MPTP Mouse Model of Parkinson’s Disease

VPS35 Mutations in Parkinson Disease

Leucine-rich repeat kinase 2 (LRRK2) regulates α-synuclein clearance in microglia

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease

Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice

Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity

ER stress response plays an important role in aggregation of [alpha]-synuclein

Transgenic mice expressing human glucocerebrosidase variants: Utility for the study of Gaucher disease

Leucine-rich repeat kinase 1 : a paralog of LRRK2 and a candidate gene for Parkinson's disease

Parkinson's disease : a rethink of rodent models

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