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Molecular Targets for Antiepileptic Drug Development

Neurotherapeutics, 2007, Vol.4 (1), p.18-61

2007

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Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology

The Journal of nutrition, 2000-04, Vol.130 (4), p.1007S-1015S

Meldrum, Brian S.

2000

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Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs

Epilepsy & behavior, 2017-06, Vol.71 (Pt B), p.165-173

2017

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Update on the Mechanism of Action of Antiepileptic Drugs

Epilepsia (Copenhagen), 1996-01, Vol.37 (s6), p.S4-S11

Meldrum, Brian S.

1996

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Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives

Progress in Brain Research, 2002, Vol.135, p.3-11

Meldrum, Brian S.

2002

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Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

Neuropharmacology, 2000-08, Vol.39 (9), p.1567-1574

2000

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Regional Expression of Multidrug Resistance Genes in Genetically Epilepsy‐prone Rat Brain after a Single Audiogenic Seizure

Epilepsia (Copenhagen), 2002-11, Vol.43 (11), p.1318-1323

2002

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Glutamate metabotropic receptors as targets for drug therapy in epilepsy

European Journal of Pharmacology, 2003-08, Vol.476 (1), p.3-16

2003

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Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA (( RS)-1-aminoindan-1,5-dicarboxylic acid)

European journal of pharmacology, 1999-02, Vol.368 (1), p.17-24

1999

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Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

Neuropharmacology, 2001-04, Vol.40 (5), p.732-735

2001

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Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, ( R, S)-4-phosphonophenylglycine

European journal of pharmacology, 1999-10, Vol.383 (1), p.23-27

1999

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Implications for neuroprotective treatments

Progress in Brain Research, 2002, Vol.135, p.487-495

Meldrum, Brian S.

2002

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Cell death after single and repeated brief seizures

Epilepsia (Copenhagen), 2010-12, Vol.51 (s5), p.35-35

2010

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Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs

Neuroreport, 1996-06, Vol.7 (9), p.1469-1474

1996

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The ‘glial’ glutamate transporter, EAAT2 (Glt‐1) accounts for high affinity glutamate uptake into adult rodent nerve endings

Journal of neurochemistry, 2003-02, Vol.84 (3), p.522-532

2003

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Excitotoxicity and Selective Neuronal Loss in Epilepsy

Brain pathology (Zurich, Switzerland), 1993-10, Vol.3 (4), p.405-412

Meldrum, Brian S.

1993

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Cerebroprotective effect of lamotrigine after focal ischemia in rats

Stroke (1970), 1995-01, Vol.26 (1), p.117-122

1995

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Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain

Brain research, 2001-06, Vol.905 (1), p.91-103

2001

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Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S, 3R, 4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid

European journal of pharmacology, 2001-07, Vol.424 (2), p.107-113

2001

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Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats

Brain research. Molecular brain research., 1996-12, Vol.43 (1), p.105-116

1996

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Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block

European journal of pharmacology, 2002-09, Vol.451 (1), p.55-61

2002

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The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine

Brain research, 1997-04, Vol.753 (2), p.283-290

1997

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Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat

Journal of cerebral blood flow and metabolism, 1998-03, Vol.18 (3), p.281-287

1998

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Elevated levels of group‐III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy‐prone rats following intracollicular administration of l‐serine‐O‐phosphate

Journal of neurochemistry, 2001-07, Vol.78 (1), p.13-23

2001

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The mGlu2/3 agonist 2R, 4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

Neuroscience letters, 2001-02, Vol.299 (1-2), p.125-129

2001

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Molecular Targets for Antiepileptic Drug Development

Glutamate as a Neurotransmitter in the Brain: Review of Physiology and Pathology

Genetically epilepsy-prone rats (GEPRs) and DBA/2 mice: Two animal models of audiogenic reflex epilepsy for the evaluation of new generation AEDs

Update on the Mechanism of Action of Antiepileptic Drugs

Concept of activity-induced cell death in epilepsy: historical and contemporary perspectives

Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

Regional Expression of Multidrug Resistance Genes in Genetically Epilepsy‐prone Rat Brain after a Single Audiogenic Seizure

Glutamate metabotropic receptors as targets for drug therapy in epilepsy

Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA (( RS)-1-aminoindan-1,5-dicarboxylic acid)

Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice

Anticonvulsant activity of a metabotropic glutamate receptor 8 preferential agonist, ( R, S)-4-phosphonophenylglycine

Implications for neuroprotective treatments

Cell death after single and repeated brief seizures

Convulsant and anticonvulsant actions of agonists and antagonists of group III mGluRs

The ‘glial’ glutamate transporter, EAAT2 (Glt‐1) accounts for high affinity glutamate uptake into adult rodent nerve endings

Excitotoxicity and Selective Neuronal Loss in Epilepsy

Cerebroprotective effect of lamotrigine after focal ischemia in rats

Neuroprotective effect of aminoguanidine on transient focal ischaemia in the rat brain

Anticonvulsant activity of a mGlu4α receptor selective agonist, (1S, 3R, 4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid

Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats

Group III mGlu receptor agonists potentiate the anticonvulsant effect of AMPA and NMDA receptor block

The vital dye Evans blue mimics limbic seizures induced by kainate or pilocarpine

Cerebroprotective effect of the nitric oxide synthase inhibitors, 1-(2-trifluoromethylphenyl) imidazole and 7-nitro indazole, after transient focal cerebral ischemia in the rat

Elevated levels of group‐III metabotropic glutamate receptors in the inferior colliculus of genetically epilepsy‐prone rats following intracollicular administration of l‐serine‐O‐phosphate

The mGlu2/3 agonist 2R, 4R-4-aminopyrrolidine-2,4-dicarboxylate, is anti- and proconvulsant in DBA/2 mice

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