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Narrow-spectrum antibacterial agents

MedChemComm, 2018-01, Vol.9 (1), p.12-21

2018

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Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study

International journal of molecular sciences, 2023-06, Vol.24 (12), p.9804

2023

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Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

mBio, 2023-06, Vol.14 (3), p.e0013723

2023

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Natural products as inspiration for the development of bacterial antibiofilm agents

Natural product reports, 2020-11, Vol.37 (11), p.1454-1477

2020

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The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

ACS infectious diseases, 2017-08, Vol.3 (8), p.559-563

2017

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2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

PloS one, 2017-07, Vol.12 (7), p.e0180925

2017

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Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

Molecular oral microbiology, 2014-10, Vol.29 (5), p.185-193

2014

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Controlling bacterial behavior with indole-containing natural products and derivatives

Tetrahedron, 2014-09, Vol.70 (37), p.6363-6372

2014

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Chemical Biology and Drug Design: Introduction to the new Editor in Chief

Chemical biology & drug design, 2023-01, Vol.101 (1), p.1-1

Melander, Roberta J.

2023

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Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants

Antibiotics (Basel), 2023-10, Vol.12 (11), p.1563

2023

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Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants

Bioorganic & medicinal chemistry letters, 2023-01, Vol.80, p.129113-129113, Article 129113

2023

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Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination

Antimicrobial agents and chemotherapy, 2024-10, Vol.68 (10), p.e0067124

2024

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Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp

Frontiers in molecular biosciences, 2018-02, Vol.5, p.15-15

2018

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Second‐Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin‐Resistant Gram‐Negative Bacteria to Colistin

ChemMedChem, 2020-09, Vol.15 (17), p.1672-1679

2020

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Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

Bioorganic & medicinal chemistry, 2019-05, Vol.27 (9), p.1776-1788

2019

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Synthesis, Stereochemical Confirmation, and Derivatization of 12(S),16ϵ‐Dihydroxycleroda‐3,13‐dien‐15,16‐olide, a Clerodane Diterpene That Sensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactam Antibiotics

Angewandte Chemie International Edition, 2022-04, Vol.61 (17), p.e202117458-n/a

International ed. in English, 2022

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Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model

European journal of medicinal chemistry, 2022-03, Vol.232, p.114203-114203, Article 114203

2022

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Identification of a 2‐Aminobenzimidazole Scaffold that Potentiates Gram‐Positive Selective Antibiotics Against Gram‐Negative Bacteria

Chembiochem : a European journal of chemical biology, 2024-04, Vol.25 (8), p.e202400127-n/a

2024

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Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin

ACS infectious diseases, 2024-04, Vol.10 (4), p.1339-1350

2024

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Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones

Bioorganic & medicinal chemistry letters, 2020-12, Vol.30 (23), p.127550-127550, Article 127550

2020

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Dimeric 2-aminoimidazoles are highly active adjuvants for gram-positive selective antibiotics against Acinetobacter baumannii

European journal of medicinal chemistry, 2023-05, Vol.253, p.115329-115329, Article 115329

2023

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Marine sponge alkaloids as a source of anti-bacterial adjuvants

Bioorganic & medicinal chemistry letters, 2016-12, Vol.26 (24), p.5863-5866

2016

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Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

ACS medicinal chemistry letters, 2018-07, Vol.9 (7), p.702-707

2018

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A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in Staphylococcus aureus

Organic & biomolecular chemistry, 2023-04, Vol.21 (16), p.3373-3380

2023

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Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram‐negative bacteria

Chemical biology & drug design, 2020-11, Vol.96 (5), p.1180-1186

2020

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Narrow-spectrum antibacterial agents

Advanced Glycation End Products as a Potential Target for Restructuring the Ovarian Cancer Microenvironment: A Pilot Study

Small Molecule Attenuates Bacterial Virulence by Targeting Conserved Response Regulator

Natural products as inspiration for the development of bacterial antibiofilm agents

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

Controlling bacterial behavior with indole-containing natural products and derivatives

Chemical Biology and Drug Design: Introduction to the new Editor in Chief

Sensitization of Gram-Negative Bacteria to Aminoglycosides with 2-Aminoimidazole Adjuvants

Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants

Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp

Second‐Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin‐Resistant Gram‐Negative Bacteria to Colistin

Tryptamine derivatives disarm colistin resistance in polymyxin-resistant gram-negative bacteria

Synthesis, Stereochemical Confirmation, and Derivatization of 12(S),16ϵ‐Dihydroxycleroda‐3,13‐dien‐15,16‐olide, a Clerodane Diterpene That Sensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactam Antibiotics

Development of small molecules that work cooperatively with ciprofloxacin to clear salmonella biofilms in a chronic gallbladder carriage model

Identification of a 2‐Aminobenzimidazole Scaffold that Potentiates Gram‐Positive Selective Antibiotics Against Gram‐Negative Bacteria

Synthesis, Stereochemical Resolution, and Analogue Synthesis of Variabiline, an Aporphine Alkaloid That Sensitizes Acinetobacter baumannii and Klebsiella pneumoniae to Colistin

Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones

Dimeric 2-aminoimidazoles are highly active adjuvants for gram-positive selective antibiotics against Acinetobacter baumannii

Marine sponge alkaloids as a source of anti-bacterial adjuvants

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition in Staphylococcus aureus

Eukaryotic phosphatase inhibitors enhance colistin efficacy in gram‐negative bacteria

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