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Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview

International journal of molecular sciences, 2021-06, Vol.22 (11), p.6047

2021

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Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials

Accounts of chemical research, 2003-06, Vol.36 (6), p.417-425

2003

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

Nature Medicine, 2004-01, Vol.10 (1), p.55-63

2004

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An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

International journal of molecular sciences, 2020-06, Vol.21 (12), p.4537

2020

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Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases

Bioorganic & medicinal chemistry, 2006-06, Vol.14 (11), p.3758-3765

2006

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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Journal of medicinal chemistry, 2012-11, Vol.55 (21), p.9312-9330

2012

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Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

PloS one, 2018-05, Vol.13 (5), p.e0196761

2018

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The protein kinase CK1: Inhibition, activation, and possible allosteric modulation

Frontiers in molecular biosciences, 2022-08, Vol.9, p.916232-916232

2022

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(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

Scientific reports, 2020-12, Vol.10 (1), p.21700-21700, Article 21700

2020

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CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (48), p.19525-19530

2013

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Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

Journal of medicinal chemistry, 2011-06, Vol.54 (12), p.4172-4186

2011

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Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

Molecules (Basel, Switzerland), 2018-01, Vol.23 (2), p.64

2018

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Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives

Journal of medicinal chemistry, 2011-07, Vol.54 (13), p.4474-4489

2011

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Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I

Molecules (Basel, Switzerland), 2014-09, Vol.19 (10), p.15546-15571

2014

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

Disease models & mechanisms, 2018-09, Vol.11 (9)

2018

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TRPC6 channel translocation into phagosomal membrane augments phagosomal function

Proceedings of the National Academy of Sciences - PNAS, 2015-11, Vol.112 (47), p.E6486-E6495

2015

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Synthesis, Resolution, and Biological Evaluation of Atropisomeric (aR)- and (aS)‑16-Methyllamellarins N: Unique Effects of the Axial Chirality on the Selectivity of Protein Kinases Inhibition

Journal of medicinal chemistry, 2013-09, Vol.56 (18), p.7289-7301

2013

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Indirubin Derivative 6BIO Suppresses Metastasis

Cancer research (Chicago, Ill.), 2013-10, Vol.73 (19), p.6004-6012

2013

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Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

PloS one, 2010-08, Vol.5 (8), p.e12117

2010

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Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases

Journal of medicinal chemistry, 2004-02, Vol.47 (4), p.935-946

2004

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Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Marine drugs, 2017-10, Vol.15 (10), p.316

2017

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Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Molecules (Basel, Switzerland), 2016-04, Vol.21 (5), p.578

2016

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Roscovitine Targets, Protein Kinases and Pyridoxal Kinase[boxs]

The Journal of biological chemistry, 2005-09, Vol.280 (35), p.31208-31219

2005

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Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

Antimicrobial Agents and Chemotherapy, 2014-03, Vol.58 (3), p.1501-1515

2014

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Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.737-751

2008

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Dual-Specificity, Tyrosine Phosphorylation-Regulated Kinases (DYRKs) and cdc2-Like Kinases (CLKs) in Human Disease, an Overview

Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical Trials

Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

An Overview of In Vivo and In Vitro Models for Autosomal Dominant Polycystic Kidney Disease: A Journey from 3D-Cysts to Mini-Pigs

Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

Molecular structures of cdc2-like kinases in complex with a new inhibitor chemotype

The protein kinase CK1: Inhibition, activation, and possible allosteric modulation

(R)-Roscovitine and CFTR modulators enhance killing of multi-drug resistant Burkholderia cenocepacia by cystic fibrosis macrophages

CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

Indole-3-Carbonitriles as DYRK1A Inhibitors by Fragment-Based Drug Design

Synthesis, Protein Kinase Inhibitory Potencies, and in Vitro Antiproliferative Activities of Meridianin Derivatives

Design and synthesis of thiazolo[5,4-f]quinazolines as DYRK1A inhibitors, part I

Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

TRPC6 channel translocation into phagosomal membrane augments phagosomal function

Synthesis, Resolution, and Biological Evaluation of Atropisomeric (aR)- and (aS)‑16-Methyllamellarins N: Unique Effects of the Axial Chirality on the Selectivity of Protein Kinases Inhibition

Indirubin Derivative 6BIO Suppresses Metastasis

Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models

Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases

Marine-Derived 2-Aminoimidazolone Alkaloids. Leucettamine B-Related Polyandrocarpamines Inhibit Mammalian and Protozoan DYRK & CLK Kinases

Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases

Roscovitine Targets, Protein Kinases and Pyridoxal Kinase[boxs]

Pharmacological Assessment Defines Leishmania donovani Casein Kinase 1 as a Drug Target and Reveals Important Functions in Parasite Viability and Intracellular Infection

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

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