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The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts

PloS one, 2012-02, Vol.7 (2), p.e31688-e31688

2012

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Biology of IL-21 and the IL-21 receptor

Immunological reviews, 2004-12, Vol.202 (1), p.84-95

2004

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In vivo maintenance of human regulatory T cells during CD25 blockade

The Journal of immunology (1950), 2015-01, Vol.194 (1), p.84-92

2015

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Well-developed ligand-binding assays demonstrate robust performance using singlet analysis

Bioanalysis, 2019-11, Vol.11 (22), p.2075-2086

2019

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IL-21 Induces the Apoptosis of Resting and Activated Primary B Cells

The Journal of immunology (1950), 2003-04, Vol.170 (8), p.4111-4118

2003

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Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN

The Journal of immunology (1950), 2009-11, Vol.183 (10), p.6545-6553

2009

Volltextzugriff (PDF)

Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice

Immunology, 2010-05, Vol.130 (1), p.103-113

2010

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NFATc2 and T-Bet Contribute to T-Helper-Cell-Subset-Specific Regulation of IL-21 Expression

Proceedings of the National Academy of Sciences - PNAS, 2005-02, Vol.102 (6), p.2016-2021

2005

Volltextzugriff (PDF)

In vivo maintenance of human regulatory T cells during CD25 blockade

Journal of neuroimmunology, 2014-01, Vol.275 (1), p.201-201

2014

Volltextzugriff (PDF)

Parallelism: the foundation of biomarker assay development and validation

Bioanalysis, 2018-06, Vol.10 (12), p.897-899

2018

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Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice

Neurology, 2019-04, Vol.92 (15), p.e1724

2019

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Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Journal of medicinal chemistry, 2020-11, Vol.63 (21), p.12526-12541

2020

Volltextzugriff (PDF)

2019 White Paper on Recent Issues in Bioanalysis: FDA Immunogenicity Guidance, Gene Therapy, Critical Reagents, Biomarkers and Flow Cytometry Validation (Part 3 – Recommendations on 2019 FDA Immunogenicity Guidance, Gene Therapy Bioanalytical Challenges, Strategies for Critical Reagent Management, Biomarker Assay Validation, Flow Cytometry Validation & CLSI H62)

Bioanalysis, 2019-12, Vol.11 (24), p.2207-2244

2019

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Immune response to vaccines is maintained in patients treated with dimethyl fumarate

Neurology : neuroimmunology & neuroinflammation, 2018-01, Vol.5 (1), p.e409-e409

2018

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Novel data analysis methods to overcome cut point challenges and enable comprehensive assessment of antidrug binding activity in confirmatory assays

Journal of immunological methods, 2013-06, Vol.392 (1-2), p.38-48

2013

Volltextzugriff (PDF)

2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays)

Bioanalysis, 2018-12, Vol.10 (24), p.1973-2001

2018

Volltextzugriff (PDF)

2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays)

Bioanalysis, 2017-12, Vol.9 (24), p.1967-1996

2017

Volltextzugriff (PDF)

Population PK–PD analyses of CD25 occupancy, CD56bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis

British journal of clinical pharmacology, 2016-11, Vol.82 (5), p.1333-1342

2016

Volltextzugriff (PDF)

Population PK-PD analyses of CD25 occupancy, CD56 bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis

British journal of clinical pharmacology, 2016-11, Vol.82 (5), p.1333-1342

2016

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Delayed-release Dimethyl Fumarate-associated Lymphopenia: On-treatment and Post-treatment Implications

Revue neurologique, 2019-04, Vol.175, p.S95-S95

2019

Volltextzugriff (PDF)

CD25 blockade with daclizumab alters regulatory T cell dynamics in RRMS patients (THER3P.880)

The Journal of immunology (1950), 2014-05, Vol.192 (1_Supplement), p.136-136.6

2014

Volltextzugriff (PDF)

PS2-018. Novel responses to dsRNA recognition in the absence of IRF3 and the type I interferon system

Cytokine (Philadelphia, Pa.), 2011-10, Vol.56 (1), p.68-68

2011

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CS2-4 Novel pathways involved in extracellular double-stranded RNA recognition, entry and signaling

Cytokine (Philadelphia, Pa.), 2010-10, Vol.52 (1-2), p.7-8

2010

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Long dsRNA induces an antiviral response independent of IRF3, IPS-1 and IFN1

The Journal of immunology (1950), 2009-10, Vol.183 (10), p.6545-6553

2009

Volltextzugriff (PDF)

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The nitric oxide pathway provides innate antiviral protection in conjunction with the type I interferon pathway in fibroblasts

Biology of IL-21 and the IL-21 receptor

In vivo maintenance of human regulatory T cells during CD25 blockade

Well-developed ligand-binding assays demonstrate robust performance using singlet analysis

IL-21 Induces the Apoptosis of Resting and Activated Primary B Cells

Long double-stranded RNA induces an antiviral response independent of IFN regulatory factor 3, IFN-beta promoter stimulator 1, and IFN

Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice

NFATc2 and T-Bet Contribute to T-Helper-Cell-Subset-Specific Regulation of IL-21 Expression

Next‐generation Bruton's tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells

In vivo maintenance of human regulatory T cells during CD25 blockade

Parallelism: the foundation of biomarker assay development and validation

Effect of dimethyl fumarate on lymphocytes in RRMS: Implications for clinical practice

Discovery of BIIB068: A Selective, Potent, Reversible Bruton’s Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Immune response to vaccines is maintained in patients treated with dimethyl fumarate

Novel data analysis methods to overcome cut point challenges and enable comprehensive assessment of antidrug binding activity in confirmatory assays

2018 White Paper on Recent Issues in Bioanalysis: focus on flow cytometry, gene therapy, cut points and key clarifications on BAV (Part 3 - LBA/cell-based assays: immunogenicity, biomarkers and PK assays)

2017 White Paper on recent issues in bioanalysis: a global perspective on immunogenicity guidelines & biomarker assay performance (Part 3 - LBA: immunogenicity, biomarkers and PK assays)

Population PK–PD analyses of CD25 occupancy, CD56bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis

Population PK-PD analyses of CD25 occupancy, CD56 bright NK cell expansion, and regulatory T cell reduction by daclizumab HYP in subjects with multiple sclerosis

Delayed-release Dimethyl Fumarate-associated Lymphopenia: On-treatment and Post-treatment Implications

CD25 blockade with daclizumab alters regulatory T cell dynamics in RRMS patients (THER3P.880)

PS2-018. Novel responses to dsRNA recognition in the absence of IRF3 and the type I interferon system

CS2-4 Novel pathways involved in extracellular double-stranded RNA recognition, entry and signaling

Long dsRNA induces an antiviral response independent of IRF3, IPS-1 and IFN1

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