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A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer

Biochemical pharmacology, 2022-10, Vol.204, p.115233-115233, Article 115233

2022

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539 Elevated IGF-1R signaling induces anti-estrogen resistance and provokes a switch from antagonistic to agonistic effect of tamoxifen in breast cancer cells

European journal of cancer supplements, 2010, Vol.8 (5), p.137-138

2010

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Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays

Environmental toxicology and chemistry, 2002-01, Vol.21 (1), p.16-23

2002

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Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes

Toxicology in vitro, 2006-09, Vol.20 (6), p.1005-1013

2006

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Urinary Excretion of Biomarkers of Oxidative Kidney Damage Induced by Ferric Nitrilotriacetate

Toxicological sciences, 1998-06, Vol.43 (2), p.241-249

1998

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Lack of p53 protein expression in preneoplastic rat hepatocytes in vitro after exposure to N-acetoxy-acetylaminofluorene, X-rays or a proteasome inhibitor

European journal of cancer (1990), 2000, Vol.36 (1), p.106-112

2000

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The effect of inhibition of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) sulphation on the initiation of γ-glutamyltranspeptidase (γ-GT) foci in rat liver

European journal of cancer & clinical oncology, 1985-11, Vol.21 (11), p.1401-1401

Meerman, J.H.N.

1985

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Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by penta-chlorophenol

Carcinogenesis (New York), 1981, Vol.2 (5), p.413-416

1981

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The initiation of γ-glutamyltranspeptidase positive foci in the rat liver by N-hydroxy-2-acetylaminofluorene. The effect of the sulfation inhibitor pentachlorophenol

Carcinogenesis (New York), 1985-06, Vol.6 (6), p.893-897

MEERMAN, J. H. N

1985

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Bioactivation of the hepatocarcinogen N-hydroxy-2-acetylaminofluorene by sulfation in the rat liver changes during the cell cycle

Life sciences (1973), 1992, Vol.51 (16), p.1255-1260

1992

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N-Acetylated and deacetylated 4'-fluoro-4-aminobiphenyl and 4-aminobiphenyl adducts differ in their ability to inhibit DNA replication of single-stranded M13 in vitro and of single-stranded φX174 in Escherichia coli

Carcinogenesis (New York), 1992-05, Vol.13 (5), p.751-758

1992

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Metabolism and Genotoxicity of the Halogenated Alkyl Compound Tris(2,3-Dibromopropyl)phosphate

Human & experimental toxicology, 1994-12, Vol.13 (12), p.861-865

1994

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Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat

Chemico-biological interactions, 1982-03, Vol.39 (2), p.149-168

1982

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DNA-adducts of the mutagen 2-bromoacrolein

European journal of cancer & clinical oncology, 1991, Vol.27, p.S50-S50

1991

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Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro

Carcinogenesis (New York), 1987-02, Vol.8 (2), p.275-279

1987

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Reaction of 2-acetylaminofluorene-N-sulfate with RNA and glutathione: evidence for the generation of two reactive intermediates with different reactivities towards RNA and glutathione

Carcinogenesis (New York), 1985-11, Vol.6 (11), p.1635-1640

1985

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Blockade of DNA synthesis by the deoxyguanosine adducts N-(deoxyguanosin-8-yl)-4-acetylaminobiphenyl and N-(deoxyguanosin-8-yl)-4′-fluoro-4-acetylaminobiphenyl

Mutation Research/Environmental Mutagenesis and Related Subjects, 1991-04, Vol.252 (2), p.188-189

1991

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Induction of micronuclei in rat hepatocytes in vivo correlates with promotion activity of hepatocarcinogens

Mutation Research/Environmental Mutagenesis and Related Subjects, 1990-12, Vol.234 (6), p.418-419

1990

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A kinase inhibitor screen reveals MEK1/2 as a novel therapeutic target to antagonize IGF1R-mediated antiestrogen resistance in ERα-positive luminal breast cancer

539 Elevated IGF-1R signaling induces anti-estrogen resistance and provokes a switch from antagonistic to agonistic effect of tamoxifen in breast cancer cells

Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays

Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes

Urinary Excretion of Biomarkers of Oxidative Kidney Damage Induced by Ferric Nitrilotriacetate

Lack of p53 protein expression in preneoplastic rat hepatocytes in vitro after exposure to N-acetoxy-acetylaminofluorene, X-rays or a proteasome inhibitor

The effect of inhibition of N-hydroxy-2-acetylaminofluorene (N-OH-AAF) sulphation on the initiation of γ-glutamyltranspeptidase (γ-GT) foci in rat liver

Role of sulfation in the formation of DNA adducts from N-hydroxy-2-acetylaminofluorene in rat liver in vivo. Inhibition of N-acetylated aminofluorene adduct formation by penta-chlorophenol

The initiation of γ-glutamyltranspeptidase positive foci in the rat liver by N-hydroxy-2-acetylaminofluorene. The effect of the sulfation inhibitor pentachlorophenol

Bioactivation of the hepatocarcinogen N-hydroxy-2-acetylaminofluorene by sulfation in the rat liver changes during the cell cycle

N-Acetylated and deacetylated 4'-fluoro-4-aminobiphenyl and 4-aminobiphenyl adducts differ in their ability to inhibit DNA replication of single-stranded M13 in vitro and of single-stranded φX174 in Escherichia coli

Metabolism and Genotoxicity of the Halogenated Alkyl Compound Tris(2,3-Dibromopropyl)phosphate

Identification of glutathione conjugates formed from N-hydroxy-2-acetylaminofluorene in the rat

DNA-adducts of the mutagen 2-bromoacrolein

Prevention by thioethers of the hepatotoxicity and covalent binding to macromolecules of N-hydroxy-2-acetylaminofluorene and its sulfate ester in rat liver in vivo and in vitro

Reaction of 2-acetylaminofluorene-N-sulfate with RNA and glutathione: evidence for the generation of two reactive intermediates with different reactivities towards RNA and glutathione

Blockade of DNA synthesis by the deoxyguanosine adducts N-(deoxyguanosin-8-yl)-4-acetylaminobiphenyl and N-(deoxyguanosin-8-yl)-4′-fluoro-4-acetylaminobiphenyl

Induction of micronuclei in rat hepatocytes in vivo correlates with promotion activity of hepatocarcinogens

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