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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Neurotoxicology (Park Forest South), 2017-03, Vol.59, p.240-255

2017

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Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Journal of applied toxicology, 2014-06, Vol.34 (6), p.595-606

2014

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Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

Critical reviews in toxicology, 2017-10, Vol.47 (9), p.733-753

2017

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Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

Pharmacology & therapeutics (Oxford), 2017-11, Vol.179, p.84-95

2017

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How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

Toxicological sciences, 2017-02, Vol.155 (2), p.326-336

2017

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IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

Critical reviews in toxicology, 2008-01, Vol.38 (2), p.87-96

2008

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Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Environmental and molecular mutagenesis, 2015-12, Vol.56 (9), p.724-750

2015

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Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Critical reviews in toxicology, 2024-02, Vol.54 (2), p.134-151

2024

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Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

Regulatory toxicology and pharmacology, 2015-08, Vol.72 (3), p.514-537

2015

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IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.781-792

2006

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Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

Critical reviews in toxicology, 2014-01, Vol.44 (1), p.1-49

2014

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The need for good practice in the application of mechanistic constructs in hazard and risk assessment

Toxicological sciences, 2023-06, Vol.194 (1), p.13-22

2023

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A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

Critical reviews in toxicology, 2003-01, Vol.33 (6), p.591-653

2003

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Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Regulatory toxicology and pharmacology, 2013-06, Vol.66 (1), p.116-129

2013

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Pragmatic Challenges for the Vision of Toxicity Testing in the 21st Century in a Regulatory Context: Another Ames Test? …or a New Edition of “the Red Book”?

Toxicological sciences, 2009-03, Vol.108 (1), p.19-21

2009

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Towards a qAOP framework for predictive toxicology - Linking data to decisions

Computational toxicology, 2022-02, Vol.21, p.100195, Article 100195

2022

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Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Critical reviews in toxicology, 2011-03, Vol.41 (3), p.175-186

2011

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Quantitative weight of evidence to assess confidence in potential modes of action

Regulatory toxicology and pharmacology, 2017-06, Vol.86, p.205-220

2017

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4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

Critical reviews in toxicology, 2006-11, Vol.36 (10), p.803-819

2006

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Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

Chemico-biological interactions, 2010-03, Vol.184 (1), p.279-285

2010

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A framework for fit-for-purpose dose response assessment

Regulatory toxicology and pharmacology, 2013-07, Vol.66 (2), p.234-240

2013

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Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Toxicology (Amsterdam), 2015-06, Vol.332, p.112-123

2015

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Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships

Journal of toxicology and environmental health. Part B, Critical reviews, 2007-04, Vol.10 (3), p.157-222

2007

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Engaging Expert Peers in the Development of Risk Assessments

Risk analysis, 2007-12, Vol.27 (6), p.1609-1621

2007

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International experience in addressing combined exposures: Increasing the efficiency of assessment

Toxicology (Amsterdam), 2013-11, Vol.313 (2-3), p.185-189

Meek, M.E. (Bette)

2013

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Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance

Adverse outcome pathways: Application to enhance mechanistic understanding of neurotoxicity

How Adverse Outcome Pathways Can Aid the Development and Use of Computational Prediction Models for Regulatory Toxicology

IPCS Framework for Analyzing the Relevance of a Noncancer Mode of Action for Humans

Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement

Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

IPCS Framework for Analyzing the Relevance of a Cancer Mode of Action for Humans

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

The need for good practice in the application of mechanistic constructs in hazard and risk assessment

A Framework for Human Relevance Analysis of Information on Carcinogenic Modes of Action

Case study illustrating the WHO IPCS guidance on characterization and application of physiologically based pharmacokinetic models in risk assessment

Pragmatic Challenges for the Vision of Toxicity Testing in the 21st Century in a Regulatory Context: Another Ames Test? …or a New Edition of “the Red Book”?

Towards a qAOP framework for predictive toxicology - Linking data to decisions

Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Quantitative weight of evidence to assess confidence in potential modes of action

4-Aminobiphenyl and DNA Reactivity: Case Study Within the Context of the 2006 IPCS Human Relevance Framework for Analysis of a Cancer Mode of Action for Humans

Proposed mode of action of benzene-induced leukemia: Interpreting available data and identifying critical data gaps for risk assessment

A framework for fit-for-purpose dose response assessment

Gaining acceptance for the use of in vitro toxicity assays and QIVIVE in regulatory risk assessment

Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships

Engaging Expert Peers in the Development of Risk Assessments

International experience in addressing combined exposures: Increasing the efficiency of assessment

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